Fluorimetric Studies of the Formation of Riboflavin-β-Cyclodextrin Inclusion Complex: Determination of the Stability Constant by use of a Non-linear Least-squares Model

1997 ◽  
Vol 49 (2) ◽  
pp. 127-130 ◽  
Author(s):  
YANNIS L. LOUKAS ◽  
VASSILIKI VRAKA ◽  
GREGORY GREGORIADIS
Keyword(s):  
Stability Constant ◽  
Inclusion Complex ◽  
Least Squares ◽  
Linear Least Squares ◽  
Cyclodextrin Inclusion ◽  
Non Linear ◽  
Cyclodextrin Inclusion Complex ◽  
The Stability

Evaluation of the phase solubility of inclusion complexes of diisopropylphenol (INN) with hydroxypropyl-β-cyclodextrin

2021 ◽  
pp. 27-32
Author(s):  
Olga Mikhailovna Balakhonova ◽  
Viktoriya Sergeevna Tyukova ◽  
Stanislav Anatolievich Kedik
Keyword(s):  
Aqueous Solution ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Tween 80 ◽  
Phase Solubility ◽  
Cyclodextrin Inclusion ◽  
Solubility Method ◽  
Cyclodextrin Inclusion Complex ◽  
The Stability ◽  
Solubility Profiles

The paper presents the results of a study of the stability of aqueous solutions of inclusion complexes of hydroxypropyl-β-cyclodextrin with diisopropylphenol in various systems by the Higuchi-Connors phase solubility method. The phase solubility profiles for each system corresponding to the AN type are determined graphically, and the stability constants of the resulting inclusion complexes are calculated. An aqueous solution containing 0.2 % Tween 80 and 0.2 % mannitol was selected as the optimal condition for obtaining the hydroxypropyl-β-cyclodextrin inclusion complex with diisopropylphenol.

scholarly journals Study of the β-Cyclodextrin Imipramine Hydrochloride Inclusion Complex and Determination of its Stability Constant (K) by UV-Visible Spectroscopy

2007 ◽  
Vol 4 (4) ◽  
pp. 550-558 ◽  
Author(s):  
Alamdar Ashnagar ◽  
Nahid Gharib Naseri ◽  
Bita Khanaki
Keyword(s):  
Stability Constant ◽  
Inclusion Complex ◽  
Visible Spectroscopy ◽  
Constant Amount ◽  
A Value ◽  
Visible Spectra ◽  
Imipramine Hydrochloride ◽  
Uv Visible ◽  
The Stability

In this research, the interactions of imipramine hydrochloride drug with β- cyclodextrin and the stability constant (K) of the inclusion complex formed between them were investigated by using UV-visible spectroscopy. Solutions consisting of a known and constant amount of imipramine hydrochloride and varying amounts of β- cyclodextrin were prepared in 0.1 M phosphate buffer (pH 7.4). The final solutions had cyclodextrin concentrations between 0.0011 and 0.0153 M. UV-visible spectra of each solution was taken at λmax= 250 nm. The absorbances at this wavelength were recorded and plotted against cyclodextrin concentrations. From the graph, the concentrations of free and bound imipramine hydrochloride and free β-cyclodextrin were calculated using the Beer-Lambert law. From these data, the stability constant was calculated and a value of K=52.26±11.41 mol-1L was obtained. The magnitude of the stability constant is discussed in terms of the relative sizes and the chemical natures of β-cyclodextrin and imipramine hydrochloride.

A direct sensitized fluorimetric determination of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin [m-THPC (Foscan)®] in human plasma using a cyclodextrin inclusion complex

The Analyst ◽  
2001 ◽  
Vol 126 (6) ◽  
pp. 923-927 ◽  
Author(s):  
Marie-Catherine Desroches ◽  
Athena Kasselouri ◽  
Pierre Chaminade ◽  
Patrice Prognon ◽  
Olivier Bourdon ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Human Plasma ◽  
Fluorimetric Determination ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex
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