scholarly journals Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation

2012 ◽  
Vol 123 (6) ◽  
pp. 997-1009 ◽  
Author(s):  
Jonathon Hull ◽  
Maya El Hindy ◽  
Patrick G. Kehoe ◽  
Katy Chalmers ◽  
Seth Love ◽  
...  
Keyword(s):  
Human Brain ◽  
Branched Chain ◽  
Branched Chain Aminotransferase

scholarly journals New insights into the role of the branched-chain aminotransferase proteins in the human brain

2015 ◽  
Vol 93 (7) ◽  
pp. 987-998 ◽  
Author(s):  
Jonathon Hull ◽  
Vinood B. Patel ◽  
Susan M. Hutson ◽  
Myra E. Conway
Keyword(s):  
Human Brain ◽  
Branched Chain ◽  
Branched Chain Aminotransferase

scholarly journals Impaired branched chain amino acid metabolism alters feeding behavior and increases orexigenic neuropeptide expression in the hypothalamus

2011 ◽  
Vol 212 (1) ◽  
pp. 85-94 ◽  
Author(s):  
Megan N Purpera ◽  
Li Shen ◽  
Marzieh Taghavi ◽  
Heike Münzberg ◽  
Roy J Martin ◽  
...  
Keyword(s):  
Amino Acid ◽  
Food Intake ◽  
Feeding Behavior ◽  
Control Diet ◽  
Peripheral Tissues ◽  
Protein Status ◽  
Branched Chain Amino Acid ◽  
Branched Chain ◽  
Branched Chain Aminotransferase ◽  
Deficient Mice

Elevation of dietary or brain leucine appears to suppress food intake via a mechanism involving mechanistic target of rapamycin, AMPK, and/or branched chain amino acid (BCAA) metabolism. Mice bearing a deletion of mitochondrial branched chain aminotransferase (BCATm), which is expressed in peripheral tissues (muscle) and brain glia, exhibit marked increases in circulating BCAAs. Here, we test whether this increase alters feeding behavior and brain neuropeptide expression. Circulating and brain levels of BCAAs were increased two- to four-fold in BCATm-deficient mice (KO). KO mice weighed less than controls (25.9 vs 20.4 g,P<0.01), but absolute food intake was relatively unchanged. In contrast to wild-type mice, KO mice preferred a low-BCAA diet to a control diet (P<0.05) but exhibited no change in preference for low- vs high-protein (HP) diets. KO mice also exhibited low leptin levels and increased hypothalamicNpyandAgrpmRNA. Normalization of circulating leptin levels had no effect on either food preference or the increasedNpyandAgrpmRNA expression. If BCAAs act as signals of protein status, one would expect reduced food intake, avoidance of dietary protein, and reduction in neuropeptide expression in BCATm-KO mice. Instead, these mice exhibit an increased expression of orexigenic neuropeptides and an avoidance of BCAAs but not HP. These data thus suggest that either BCAAs do not act as physiological signals of protein status or the loss of BCAA metabolism within brain glia impairs the detection of protein balance.

Role of Branched-Chain Aminotransferase Isoenzymes and Gabapentin in Neurotransmitter Metabolism

2002 ◽  
Vol 71 (2) ◽  
pp. 863-874 ◽  
Author(s):  
S. M. Hutson ◽  
D. Berkich ◽  
P. Drown ◽  
Baiyang Xu ◽  
Michael Aschner ◽  
...  
Keyword(s):  
Branched Chain ◽  
Branched Chain Aminotransferase ◽  
Neurotransmitter Metabolism

scholarly journals Altered Expression of Human Mitochondrial Branched Chain Aminotransferase in Dementia with Lewy Bodies and Vascular Dementia

2016 ◽  
Vol 42 (1) ◽  
pp. 306-319 ◽  
Author(s):  
Emma L. Ashby ◽  
Marta Kierzkowska ◽  
Jonathon Hull ◽  
Patrick G. Kehoe ◽  
Susan M. Hutson ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Altered Expression ◽  
Branched Chain ◽  
Branched Chain Aminotransferase

scholarly journals Cloning and Expression of the Mammalian Cytosolic Branched Chain Aminotransferase Isoenzyme

1995 ◽  
Vol 270 (51) ◽  
pp. 30344-30352 ◽  
Author(s):  
Susan M. Hutson ◽  
Randy K. Bledsoe ◽  
Timothy R. Hall ◽  
Paul A. Dawson
Keyword(s):  
Cloning And Expression ◽  
Branched Chain ◽  
Branched Chain Aminotransferase
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