scholarly journals Rostral ventromedial medulla‐mediated descending facilitation following P2X7 receptor activation is involved in the development of chronic post‐operative pain

2019 ◽  
Vol 149 (6) ◽  
pp. 760-780 ◽  
Author(s):  
Wei Wang ◽  
Xiongxiong Zhong ◽  
Yongyong Li ◽  
Ruixian Guo ◽  
Sujuan Du ◽  
...  
Keyword(s):  
P2x7 Receptor ◽  
Receptor Activation ◽  
Rostral Ventromedial Medulla ◽  
Descending Facilitation ◽  
Post Operative Pain ◽  
Ventromedial Medulla ◽  
P2x7 Receptor Activation

scholarly journals Possible Involvement of P2X7 Receptor Activation in Microglial Neuroprotection against Focal Cerebral Ischemia in Rats

2008 ◽  
Vol 31 (6) ◽  
pp. 1121-1130 ◽  
Author(s):  
Daijiro Yanagisawa ◽  
Yoshihisa Kitamura ◽  
Kazuyuki Takata ◽  
Izumi Hide ◽  
Yoshihiro Nakata ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
P2x7 Receptor ◽  
Focal Cerebral Ischemia ◽  
Receptor Activation ◽  
P2x7 Receptor Activation

Calmidazolium selectively inhibits exocytotic glutamate release evoked by P2X7 receptor activation

2012 ◽  
Vol 60 (8) ◽  
pp. 768-772 ◽  
Author(s):  
Chiara Cervetto ◽  
Maria Chiara Mazzotta ◽  
Daniela Frattaroli ◽  
Susanna Alloisio ◽  
Mario Nobile ◽  
...  
Keyword(s):  
P2x7 Receptor ◽  
Glutamate Release ◽  
Receptor Activation ◽  
P2x7 Receptor Activation

scholarly journals Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors

2012 ◽  
Vol 107 (4) ◽  
pp. 1210-1221 ◽  
Author(s):  
Thaddeus S. Brink ◽  
Cholawat Pacharinsak ◽  
Sergey G. Khasabov ◽  
Alvin J. Beitz ◽  
Donald A. Simone
Keyword(s):  
Rostral Ventromedial Medulla ◽  
Intraplantar Injection ◽  
Nociceptive Transmission ◽  
Descending Facilitation ◽  
Pain Transmission ◽  
Ventromedial Medulla ◽  
Neurokinin 1 ◽  
Excitatory Responses ◽  
Heat Hyperalgesia

The rostral ventromedial medulla (RVM) is part of descending circuitry that modulates nociceptive processing at the level of the spinal cord. RVM output can facilitate pain transmission under certain conditions such as inflammation, and thereby contribute to hyperalgesia. Evidence suggests that substance P and activation of neurokinin-1 (NK-1) receptors in the RVM are involved in descending facilitation of nociception. We showed previously that injection of NK-1 receptor antagonists into the RVM attenuated mechanical and heat hyperalgesia produced by intraplantar injection of capsaicin. Furthermore, intraplantar injection of capsaicin excited ON cells in the RVM and inhibited ongoing activity of OFF cells. In the present studies, we therefore examined changes in responses of RVM neurons to mechanical and heat stimuli after intraplantar injection of capsaicin and determined the role of NK-1 receptors by injecting a NK-1 receptor antagonist into the RVM prior to capsaicin. After capsaicin injection, excitatory responses of ON cells and inhibitory responses of OFF cells evoked by mechanical and heat stimuli applied to the injected, but not contralateral, paw were increased. Injection of the NK-1 antagonist L-733,060 did not alter evoked responses of ON or OFF cells but attenuated the capsaicin-evoked enhanced responses of ON cells to mechanical and heat stimuli with less of an effect on the enhanced inhibitory responses of OFF cells. These data support the notion that descending facilitation from RVM contributes to hyperalgesia and that NK-1 receptors, presumably located on ON cells, play an important role in initiating descending facilitation of nociceptive transmission.

MSU Crystals induce sterile IL-1β secretion via P2X7 receptor activation and HMGB1 release

2020 ◽  
Vol 1864 (1) ◽  
pp. 129461 ◽  
Author(s):  
Ygor Marinho ◽  
Camila Marques-da-Silva ◽  
Patricia Teixeira Santana ◽  
Mariana Martins Chaves ◽  
Augusto Shuiti Tamura ◽  
...  
Keyword(s):  
P2x7 Receptor ◽  
Receptor Activation ◽  
P2x7 Receptor Activation ◽  
Msu Crystals

scholarly journals P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2

2015 ◽  
Vol 128 (24) ◽  
pp. 4615-4628 ◽  
Author(s):  
M. Adamczyk ◽  
R. Griffiths ◽  
S. Dewitt ◽  
V. Kna uper ◽  
D. Aeschlimann
Keyword(s):  
P2x7 Receptor ◽  
Transglutaminase 2 ◽  
Receptor Activation ◽  
P2x7 Receptor Activation

scholarly journals P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation

2013 ◽  
Vol 73 ◽  
pp. 311-319 ◽  
Author(s):  
Ukpong B. Eyo ◽  
Sam A. Miner ◽  
Katelin E. Ahlers ◽  
Long-Jun Wu ◽  
Michael E. Dailey
Keyword(s):  
Cell Death ◽  
P2x7 Receptor ◽  
Microglial Cell ◽  
Glucose Deprivation ◽  
Receptor Activation ◽  
Oxygen Glucose Deprivation ◽  
P2x7 Receptor Activation

scholarly journals P2X7 receptor activation induces cell death and microparticle release in murine erythroleukemia cells

2010 ◽  
Vol 1798 (9) ◽  
pp. 1797-1804 ◽  
Author(s):  
Patrick Constantinescu ◽  
Bin Wang ◽  
Kati Kovacevic ◽  
Iman Jalilian ◽  
Giel J.C.G.M. Bosman ◽  
...  
Keyword(s):  
Cell Death ◽  
P2x7 Receptor ◽  
Receptor Activation ◽  
Erythroleukemia Cells ◽  
Murine Erythroleukemia ◽  
P2x7 Receptor Activation ◽  
Murine Erythroleukemia Cells

scholarly journals Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla

2017 ◽  
Vol 118 (5) ◽  
pp. 2727-2744 ◽  
Author(s):  
Sergey G. Khasabov ◽  
Patrick Malecha ◽  
Joseph Noack ◽  
Janneta Tabakov ◽  
Glenn J. Giesler ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Dynamic Range ◽  
Receptor Activation ◽  
Rostral Ventromedial Medulla ◽  
Dorsal Horn Neurons ◽  
Descending Modulation ◽  
Ventromedial Medulla ◽  
Neurokinin 1 ◽  
Wdr Neurons

Neurons in the rostral ventromedial medulla (RVM) project to the spinal cord and are involved in descending modulation of pain. Several studies have shown that activation of neurokinin-1 (NK-1) receptors in the RVM produces hyperalgesia, although the underlying mechanisms are not clear. In parallel studies, we compared behavioral measures of hyperalgesia to electrophysiological responses of nociceptive dorsal horn neurons produced by activation of NK-1 receptors in the RVM. Injection of the selective NK-1 receptor agonist Sar9,Met(O2)11-substance P (SSP) into the RVM produced dose-dependent mechanical and heat hyperalgesia that was blocked by coadministration of the selective NK-1 receptor antagonist L-733,060. In electrophysiological studies, responses evoked by mechanical and heat stimuli were obtained from identified high-threshold (HT) and wide dynamic range (WDR) neurons. Injection of SSP into the RVM enhanced responses of WDR neurons, including identified neurons that project to the parabrachial area, to mechanical and heat stimuli. Since intraplantar injection of capsaicin produces robust hyperalgesia and sensitization of nociceptive spinal neurons, we examined whether this sensitization was dependent on NK-1 receptors in the RVM. Pretreatment with L-733,060 into the RVM blocked the sensitization of dorsal horn neurons produced by capsaicin. c-Fos labeling was used to determine the spatial distribution of dorsal horn neurons that were sensitized by NK-1 receptor activation in the RVM. Consistent with our electrophysiological results, administration of SSP into the RVM increased pinch-evoked c-Fos expression in the dorsal horn. It is suggested that targeting this descending pathway may be effective in reducing persistent pain. NEW & NOTEWORTHY It is known that activation of neurokinin-1 (NK-1) receptors in the rostral ventromedial medulla (RVM), a main output area for descending modulation of pain, produces hyperalgesia. Here we show that activation of NK-1 receptors produces hyperalgesia by sensitizing nociceptive dorsal horn neurons. Targeting this pathway at its origin or in the spinal cord may be an effective approach for pain management.

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