scholarly journals Combined value of placental alpha microglobulin-1 detection and cervical length via transvaginal ultrasound in the diagnosis of preterm labor in symptomatic patients

2017 ◽  
Vol 43 (8) ◽  
pp. 1263-1269 ◽  
Author(s):  
Vyacheslav Bolotskikh ◽  
Vera Borisova
Author(s):  
Prasila Ekaputri

Objectives: To determine the cut off point of cervical length usingtransvaginal ultrasonography to predict the actual occurrence ofpreterm labor in women with threatened preterm labor. Methods: A cross sectional study with consecutive random samplingmethod. We examined 80 women with singleton pregnancycomplaining of regular, painful uterine contraction and rupturedmembrane at 24-36 weeks of gestation. Women in active labor, definedby the presence of cervical dilatation less than or equal 3 cm, and having complicationwere excluded. When the patient was admitted, a transvaginalscan was performed to measure the cervical length. Parenteralmagnesium sulfate was given as the subsequent management.The primary outcome was delivery within 24 hours of presentation.Results: We found that the optimal cut off values for cervical lengthwas 2.65 cm with sensitivity 94.4 Percent, specificity 65.4Percent, positive predictivevalue 75.4 Percent and negative predictive value 81.8 Percent. In 69cases, the cervical length was more than or 2.65 cm, with 52 patients successfullycontinued their pregnancy until more than 24 hours. In the 11cases with cervical length less than or equal 2.65 cm, delivery within 24 hours occurredin 9 cases (81,8 Percent). Conclusion: The findings of this study suggest that in women withthreatened preterm labor, cervical length more than or equal 2.65 cm may help predictthe actual occurrence of preterm labor. Keywords: cervical length, threatened preterm labor, transvaginalultrasonography


Author(s):  
Mehbooba Beigh ◽  
Mohammed Farooq Mir ◽  
Rifat Amin ◽  
Simrath Shafi

Background: Preterm delivery (PTD) is a major cause of perinatal morbidity and mortality. Objective of present study was to identify the women at risk of preterm delivery with the help of trans-vaginal ultrasound by assessing cervical length changes, funneling of lower uterine segment, cervical dilatation.Methods: A prospective study was carried out over a period of 2 years on 50 patients with 24-36 weeks of gestation who clinically presented with signs of threatened preterm labor and were subjected to transvaginal sonographic measurement of cervical length.Results: Prediction of spontaneous preterm birth at <37 weeks of gestation with cervical length to be 2.75 cm has sensitivity of 95%, specificity of 96.5%, positive predictive value of 86.36% and negative predictive value of 98.7%.Conclusions: Transvaginal ultrasonography is the reliable, reproducible and objective method to assess cervix and to predict the risk of preterm delivery.


2000 ◽  
Vol 70 ◽  
pp. B158-B158
Author(s):  
W. Winograd ◽  
M. Poncelas ◽  
C. Damonte ◽  
S. Vigo ◽  
G. Schwarzberg ◽  
...  

2014 ◽  
Vol 290 (3) ◽  
pp. 465-469 ◽  
Author(s):  
T. Gauthier ◽  
B. Marin ◽  
A. Garuchet-Bigot ◽  
D. Kanoun ◽  
C. Catalan ◽  
...  

2021 ◽  
Vol 3 ◽  
pp. 57-64
Author(s):  
Ye. Petrenko ◽  
K.P. Strubchevka

Preterm labor is the leading cause of neonatal mortality and the most common cause for antenatal hospitalization. Approximately 15 million babies are born preterm each year worldwide. Of those, one million babies die before the age of 5, which is 18% of all deaths of children at this age. 35% of early and late neonatal mortality (under 28 days of age) is associated with preterm birth.The pathophysiology of preterm labor includes at least four major pathogenetic mechanisms. The studied components of this process are premature activation of the maternal or fetal hypothalamic-pituitary-adrenal system, inflammation or infection, decidual hemorrhage and pathological overdistension of the uterus. The diagnosis of preterm labor is based on the determination of concomitant regular uterine contractions and cervical changes. Vaginal bleeding and/or rupture of the amniotic membranes only increase the likelihood of this diagnosis. To improve the accuracy of diagnosis and assess the potential risk of preterm birth in the presence of symptoms in pregnant women, it is proposed to use such diagnostic tests as transvaginal ultrasound to measure cervical length; detection in vaginal fluids of fetal fibronectin (fFN), phosphorylated protein-1, which binds insulin-like growth factor (IGFBP-1), placental alpha-microglobulin, the ratio of insulin-like growth factorebinding protein 4 (IBP4) and sex hormoneebinding globulin (SHBG) – PreTRM-test.Correct identification of women in the true preterm labor allows performing appropriate actions, which results in better outcomes for the newborn. These are using of corticosteroids to prevent respiratory distress syndrome (RDS) of the newborn; prevention of group B streptococcal infection; magnesium sulfate to protect the baby’s nervous system; transportation to the institution of the third level of perinatal care, which can provide a newborn with appropriate medical care. Preventative and therapeutic measures for women, which have a high risk of preterm labor, include taking progesterone, cervical cerclage and an application of obstetric pessary.


2011 ◽  
Vol 2 (1) ◽  
pp. 15-18
Author(s):  
Igal Wolman ◽  
Arnon Agmon ◽  
J Ariel

ABSTRACT Prevention of preterm labor will reduce perinatal mortality. Screening of cervical length by ultrasound should begin at 16 weeks by transvaginal ultrasound. If the cervical length is more than 35 mm, the exam should be repeated every 2 to 3 weeks till 32 weeks. If the cervical length is between 25 and 35 mm the ultrasound screening should be done weekly or biweekly. Fetal fibronectin estimation should provide supplemental information. If the cervical length is less than 25 mm cervical cerclage should be performed if gestational age is less than 22 weeks. Progesterone therapy is preferred if the gestational age is more than 22 completed weeks.


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