Author response for "The association between Epstein‐Barr virus and oral lichen planus: A systematic review and meta‐analysis"

2020 ◽  
Author(s):  
Sajna Ashraf ◽  
Sadeq Ali Al‐Maweri ◽  
Nader Alaizari ◽  
Ayesha Umair ◽  
Zaihan Ariffin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lichen Planus ◽  
Epstein Barr Virus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Author Response ◽  
Barr Virus ◽  
Epstein Barr ◽  
Oral Lichen

The association between Epstein‐Barr virus and oral lichen planus: A systematic review and meta‐analysis

2020 ◽  
Vol 49 (10) ◽  
pp. 969-976
Author(s):  
Sajna Ashraf ◽  
Sadeq A. Al‐Maweri ◽  
Nader Alaizari ◽  
Ayesha Umair ◽  
Zaihan Ariffin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lichen Planus ◽  
Epstein Barr Virus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Barr Virus ◽  
Epstein Barr ◽  
Oral Lichen

Epstein-Barr Virus–Infected Plasma Cells Infiltrate Erosive Oral Lichen Planus

2018 ◽  
Vol 97 (13) ◽  
pp. 1494-1500 ◽  
Author(s):  
H. Raybaud ◽  
C.V. Olivieri ◽  
L. Lupi-Pegurier ◽  
S. Pagnotta ◽  
R. Marsault ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Epstein Barr Virus ◽  
Oral Lichen Planus ◽  
Plasma Cells ◽  
Inflammatory Factors ◽  
Barr Virus ◽  
Ebv Infection ◽  
Inflammatory Status ◽  
Epstein Barr ◽  
Oral Lichen

Epstein-Barr virus (EBV), in addition to its transforming properties, contributes to the pathogenesis of several inflammatory diseases. Here, we investigated its involvement in oral lichen planus (OLP), a common autoimmune-like disease of unknown etiopathogenesis that can display a malignant potential. EBV-infected cells (EBV+ cells) were sought in a large series of clinically representative OLPs ( n = 99) through in situ hybridization to detect small noncoding EBV-encoded RNAs. Overall, our results demonstrated that EBV was commonly found in OLP (74%), with significantly higher frequency (83%) in the erosive form than in the reticular/keratinized type mild form (58%). Strikingly, many erosive OLPs were massively infiltrated by large numbers of EBV+ cells, which could represent a large part of the inflammatory infiltrate. Moreover, the number of EBV+ cells in each OLP section significantly correlated with local inflammatory parameters (OLP activity, infiltrate depth, infiltrate density), suggesting a direct relationship between EBV infection and inflammatory status. Finally, we characterized the nature of the infiltrated EBV+ cells by performing detailed immunohistochemistry profiles ( n = 21). Surprisingly, nearly all EBV+ cells detected in OLP lesions were CD138+ plasma cells (PCs) and more rarely CD20+ B cells. The presence of EBV+ PCs in erosive OLP was associated with profound changes in cytokine expression profile; notably, the expression of key inflammatory factors, such as IL1-β and IL8, were specifically increased in OLP heavily infiltrated with EBV+ PCs. Moreover, electron microscopy–based experiments showed that EBV+ PCs actively produced EBV viral particles, suggesting possible amplification of EBV infection within the lesion. Our study thus brings conclusive evidence showing that OLP is commonly infiltrated with EBV+ PCs, adding a further puzzling element to OLP pathogenesis, given that PCs are now considered to be major regulatory immune cells involved in several autoimmune diseases (ClinicalTrials.gov NCT02276573).

scholarly journals Detection of Epstein–Barr virus in different sources of materials from patients with oral lichen planus: a case–control study

2015 ◽  
Vol 69 (4) ◽  
pp. 358-363 ◽  
Author(s):  
Rúbia da Rocha Vieira ◽  
Lígia Lavezo Ferreira ◽  
Éder Ricardo Biasoli ◽  
Daniel Galera Bernabé ◽  
Cáris Maroni Nunes ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Epstein Barr Virus ◽  
Oral Lichen Planus ◽  
Case Control Study ◽  
Case Control ◽  
Barr Virus ◽  
Epstein Barr ◽  
Oral Lichen ◽  
Different Sources ◽  
Control Study
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