The role of extracellular matrix metalloproteinase inducer glycosylation in regulating matrix metalloproteinases in periodontitis

2018 ◽  
Vol 53 (3) ◽  
pp. 391-402 ◽  
Author(s):  
Z. Zhang ◽  
X. Yang ◽  
H. Zhang ◽  
X. Liu ◽  
S. Pan ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Extracellular Matrix Metalloproteinase Inducer

scholarly journals Matrix Metalloproteinase Inhibition in a Murine Model of Cavitary Tuberculosis Paradoxically Worsens Pathology

2018 ◽  
Vol 219 (4) ◽  
pp. 633-636 ◽  
Author(s):  
Alvaro A Ordonez ◽  
Supriya Pokkali ◽  
Julian Sanchez-Bautista ◽  
Mariah H Klunk ◽  
Michael E Urbanowski ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Mycobacterium Tuberculosis ◽  
Matrix Metalloproteinases ◽  
Pulmonary Tuberculosis ◽  
Matrix Metalloproteinase ◽  
Murine Model ◽  
Potent Inhibitor ◽  
Mmp Inhibitors

Abstract Matrix metalloproteinases (MMPs) degrade extracellular matrix and are implicated in tuberculosis pathogenesis and cavitation. In particular, MMP-7 is induced by hypoxia and highly expressed around pulmonary cavities of Mycobacterium tuberculosis–infected C3HeB/FeJ mice. In this study, we evaluated whether administration of cipemastat, an orally available potent inhibitor of MMP-7, could reduce pulmonary cavitation in M. tuberculosis–infected C3HeB/FeJ mice. We demonstrate that, compared with untreated controls, cipemastat treatment paradoxically increases the frequency of cavitation (32% vs 7%; P = .029), immunopathology, and mortality. Further studies are needed to understand the role of MMP inhibitors as adjunctive treatments for pulmonary tuberculosis.

scholarly journals Expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinases during mouse embryonic development

Reproduction ◽  
2007 ◽  
Vol 133 (2) ◽  
pp. 405-414 ◽  
Author(s):  
Li Chen ◽  
Masaaki Nakai ◽  
Robert J Belton ◽  
Romana A Nowak
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Embryo Development ◽  
Mouse Embryo ◽  
Expression Profiles ◽  
Embryo Implantation ◽  
Rt Pcr ◽  
Extracellular Matrix Metalloproteinase Inducer

Mouse embryo implantation is a highly invasive and controlled process that involves remodeling and degradation of the extracellular matrix of the uterus. Matrix metalloproteinases (MMPs) are the main proteinases facilitating this process. Extracellular matrix metalloproteinase inducer (EMMPRIN) can stimulate the production of MMPs and is required for successful implantation in the mouse. The aims of the present study were to examine the expression profiles of mRNA and proteins for EMMPRIN and MMPs in the developing mouse embryo in vitro, and to study whether EMMPRIN protein induces the production of MMPs by mouse blastocysts. EMMPRIN mRNA, detected by RT-PCR, was present at all stages of embryo development from the one-cell to the blastocyst outgrowth. EMMPRIN protein, observed by confocal microscopy, was present on the cell surface at the same stages of development as was the mRNA. Of seven MMPs studied, murine collagenase-like A (Mcol-A), murine collagenase-like B (Mcol-B) and gelatinase A (MMP-2) mRNAs were detected only in blastocyst outgrowths by RT-PCR. Gelatinase B (MMP-9) mRNA was detected both in expanded blastocysts and blastocyst outgrowths. MMP-2 and -9 proteins were detected in the cytoplasm of outgrowing trophoblast cells. Collagenase-2 (MMP-8), collagenase-3 (MMP-13), or stromelysin-1 (MMP-3) mRNAs were not present at any stage of pre- or peri-implantation mouse embryo development. Quantitative RT-PCR analyses showed that recombinant EMMPRIN protein did not stimulate MMP-2 or -9 expression by mouse blastocyst outgrowths. These data suggest that EMMPRIN may regulate physiological functions other than MMP production by mouse embryos during implantation.

The role of extracellular matrix metalloproteinase inducer protein in prostate cancer progression

2008 ◽  
Vol 57 (9) ◽  
pp. 1367-1379 ◽  
Author(s):  
Michele C. Madigan ◽  
Elizabeth A. Kingsley ◽  
Paul J. Cozzi ◽  
Warick J. Delprado ◽  
Pamela J. Russell ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Extracellular Matrix Metalloproteinase Inducer
Sign in / Sign up

Export Citation Format

Share Document