scholarly journals Comparison of clot-based, chromogenic and fluorescence assays for measurement of factor VIII inhibitors in the US Hemophilia Inhibitor Research Study

2013 ◽  
Vol 11 (7) ◽  
pp. 1300-1309 ◽  
Author(s):  
C. H. Miller ◽  
A. S. Rice ◽  
B. Boylan ◽  
A. D. Shapiro ◽  
S. R. Lentz ◽  
...  
Keyword(s):  
Factor Viii ◽  
Research Study ◽  
The Us ◽  
Fluorescence Assays

scholarly journals Understanding Disease Burden Among Persons with Hemophilia Α without Inhibitors

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 4690-4690
Author(s):  
Wendy E Owens ◽  
Anissa Cyhaniuk ◽  
Anisha Patel ◽  
Karina Raimundo ◽  
Elaine Chan ◽  
...  
Keyword(s):  
Factor Viii ◽  
Disease Burden ◽  
Hemophilia A ◽  
Pain Medication ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Daily Work ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
The Us

Abstract Introduction Previous studies have reported significant disease burden in persons with hemophilia A (PwHA) who develop inhibitors to factor VIII. However, disease burden in PwHA without inhibitors (PwHA-WO) is not well understood across severities. The CHOICE Project was conducted in partnership between the US Centers for Disease Control and Prevention and the Hemophilia Federation of America to survey persons with bleeding disorders of varying severity, male and female, in the US. Participants in the CHOICE Project included both patients receiving care at federally funded hemophilia treatment centers (HTC) and those who do not receive care at HTCs. The objective of the study was to assess and characterize self-reported clinical outcomes, care, and quality of life (QoL) of PwHA-WO across all disease severities. Methods A retrospective analysis was conducted of data collected through the CHOICE Project, a cross-sectional survey, from April 2013 to July 2015. Adults (≥18 years) and caregivers of children with hemophilia A (HA) were recruited to take the 20-minute CHOICE survey, online or on paper, in English or Spanish. The overall response rate to survey questions was approximately 87%, but it varied by survey item, as participants could opt not to respond to certain questions. PwHA-WO were defined as HA persons that reported no current or past factor VIII inhibitors. In this analysis, self-reported demographics, bleed- and joint-related outcomes, treatment, and QoL among PwHA-WO were descriptively analyzed by self-reported disease severity. Results Of the total 429 PwHA surveyed, 328 (76%) reported no current or past inhibitors (PwHA-WO). The majority of PwHA-WO were adults (59%), males (80%), non-Hispanic (76%), or white (63%) and had commercial insurance (68%). More than a quarter reported depression or anxiety, while 13% and 23% reported diagnosis of human immunodeficiency virus and hepatitis C, respectively. Most patients reported seeking care from a hematologist (96%) or at an HTC (63%). Among PwHA-WO, a higher proportion reported having severe HA (severe, 63%; moderate, 15%; mild, 22%). Overall, 94% of PwHA-WO reported they had ever experienced a bleed (severe, 96%; moderate, 96%; mild, 88%; p=0.42), and more than 85% reported they had ever had a joint bleed (severe, 88%; moderate, 91%; mild, 72%; p=0.006). In the last 12 months, approximately 73% reported a joint bleed (severe, 76%; moderate, 78%; mild, 56%; p=0.025) and 65% reported a bleed in another location (severe, 70%; moderate, 62%; mild, 51%; p=0.17). About 15% and 22% of PwHA-WO reported a history of synovectomy (severe, 18%; moderate, 7%; mild, 11%; p=0.30) or joint replacement surgery (severe, 28%; moderate,19%; mild, 5%; p=0.015). Over 28% of PwHA-WO reported having joint problems such as pain, stiffness, and loss of motion "always" or "frequently" (severe, 32%; moderate, 29%; mild, 15%; p=0.23). About a quarter responded that these problems "always" or "frequently" limited their daily work/school, recreational, and/or self-care activities (severe, 29%; moderate, 24%; mild, 20%; p=0.46). On average, PwHA-WO reported 16 missed days from work, school, or usual activities due to their disease (severe, 12; moderate, 30; mild, 16; p=0.014). Nearly 66% of PwHA-WO reported using over-the-counter pain medication in the last 30 days (severe, 62%; moderate, 80%; mild, 67%; p=0.31) and over a third reported using prescription pain medication over the same period (severe, 44%; moderate, 30%; mild, 11%; p=0.01). Conclusions This study suggests that considerable clinical, emotional, and day-to-day disease burden exists in PwHA-WO, even among those with mild and moderate severity. Although joint bleed-related outcomes varied by severity, patients with moderate HA reported joint-related outcomes comparable to those with severe HA. However, limitation of daily activities did not differ by severity. PwHA-WO with mild, moderate and severe HA reported limitation in physical activities, which can impair their QoL. Better understanding of disease burden by severity among PwHA-WO will help in planning future interventions to address these burdens and improve health outcomes. Disclosures Owens: Divitius LLC: Employment; Genentech Inc.: Consultancy; HFA: Consultancy. Cyhaniuk:Independent Contractor: Consultancy; HFA: Employment; AC Analytical Solutions, LLC: Employment. Patel:Genentech Inc: Employment. Raimundo:Genentech Inc: Employment, Other: Ownership interests PLC. Chan:Hemophilia Federation of America: Employment. Ko:Genentech Inc: Employment; F. Hoffmann-La Roche Ltd: Other: Ownership interests non-PLC.

Sustainability marketing: US hotels vs. international hotel chains

2015 ◽  
Vol 11 (1) ◽  
pp. 32-36 ◽  
Author(s):  
Lana Brackett ◽  
B. Nathaniel Carr II
Keyword(s):  
Web Site ◽  
Design Methodology ◽  
Research Study ◽  
Hotel Industry ◽  
Exploratory Research ◽  
Content Type ◽  
Large Market ◽  
The Us ◽  
Hotel Chains ◽  
The Web

Purpose – The purpose of this paper is to determine whether US-only hotels and US-based international hotel chains similarly promote sustainability marketing. Design/methodology/approach – A qualitative exploratory research study reviewing the web site marketing of the US-only hotels and US-based international hotel chains. Findings – The research indicates that there are differences in the sustainability marketing of US-only and US-based international hotel chains. Originality/value – This is a unique research study. The hotel industry has a diverse body of stateholders due to its large market and impact on sustainability.

scholarly journals Pool Fire and Fireball Experiments in Support of the US DOE/DOT/TC Crude Oil Characterization Research Study.

2019 ◽  
Author(s):  
Anay Luketa ◽  
Thomas K. Blanchat ◽  
David Lord ◽  
Joseph Hogge ◽  
Alvaro Augusto Cruz-Cabrera ◽  
...  
Keyword(s):  
Crude Oil ◽  
Research Study ◽  
Pool Fire ◽  
The Us ◽  
Oil Characterization

scholarly journals Luxury wine: analyzing motivations of luxury wine buyers in the US market

2019 ◽  
Vol 13 (3-4) ◽  
pp. 51-58
Author(s):  
Liz Thach ◽  
Janeen Olsen
Keyword(s):  
Online Survey ◽  
Research Study ◽  
Jel Classification ◽  
Education Level ◽  
The Us

The purpose of this research study was to describe motivations and demographics of luxury wine buyers in the US market. An online survey was completed by 1081 US wine consumers, of which 473 were designated to be luxury buyers based on price spent on wine. Standard demographic and wine consumer scales were utilized for profiling. Results show that the luxury wine buyer is more likely to be male, aged 30 to 50, with a higher income and education level. Motivations of the luxury wine buyer are different than the non-luxury wine buyer, and reasons for purchasing luxury wine go beyond mere collecting. This research is one of the first to analyze the luxury wine consumer in the US market, and provides useful information for wine marketers and researchers on the profile of the luxury wine buyer in America. JEL Classification: M31

Abstract TP136: A Retrospective Study of Moyamoya in a Unique, Primarily Caucasian Southern US Population

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Ibrahim Z Noorbhai ◽  
Justin F Fraser ◽  
Jessica D Lee
Keyword(s):  
Factor Viii ◽  
Lipid Analysis ◽  
Case Series ◽  
Retrospective Chart Review ◽  
Asian Population ◽  
Fold Increase ◽  
Autoimmune Disorders ◽  
Markers Of Inflammation ◽  
Southern Us ◽  
The Us

Background: Moyamoya (MM) is an uncommon cerebrovascular disease characterized by bilateral, progressive stenosis and occlusion at the terminal portion of the internal carotid arteries around the circle of Willis. MM has a higher prevalence in East Asian population; however, an increasing number of cases of MM are being reported in the US and may reflect a different entity often termed moyamoya syndrome (MMS). A study from 2005 to 2008, reported a 4-fold increase in the prevalence of MM in the US. In this study, we sought to describe the clinical features of patients diagnosed with MMS in a unique, primarily Caucasian Southern US population. Materials and Methods: We performed a retrospective chart review of patients evaluated at our institution from August 2012 to December 2018. Data collected included age, sex, ethnicity, comorbid medical conditions, and laboratory values. Results: Seventy-seven patients with MM were included (52 female and 25 male), average age at time of diagnosis was 42 for females and 48 for males. 81% were Caucasian while 17% were African American, and 3% were Asian. Hypertension was the most common comorbidity affecting these individuals (60%), with hyperlipidemia being the second most common (36%). Autoimmune disorders affected about 22% of this population. The average BMI of females and males was 35 and 29, respectively. Lipid analysis showed similarity in profiles between males and females, and no significant trends were appreciated respective to BMI and age. Interestingly, 85% of individuals had an elevation of sedimentation rate (ESR), Factor VIII, or C - reactive protein (CRP) at the time of diagnosis. Conclusions: Women are affected in a 2:1 ratio as compared to men; which is a consistent trend reported in other studies. Hypertension remains the most common comorbidity affecting these individuals. Though the etiology of MMS remains unclear, various autoimmune disorders have been reported in small case series. While ESR, factor VIII activity, and CRP are non-specific markers of inflammation, the high prevalence of these markers in this population further support an autoimmune or immunological component in MM. Additional prospective studies are needed to further elucidate this relationship.

scholarly journals 848. Approaches to Optimize Recruitment of Historically Underrepresented Black and Hispanic/LatinX MSM, Transgender, and Gender Non-binary Individuals into the Lenacapavir for PrEP (PURPOSE 2) Trial

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S514-S514
Author(s):  
Michelle Cespedes ◽  
Jill Blumenthal ◽  
Karam Mounzer ◽  
Moti Ramgopal ◽  
Theo Hodge ◽  
...  
Keyword(s):  
Research Study ◽  
Scientific Research ◽  
Panel Member ◽  
Hiv Incidence ◽  
Community Based ◽  
Review Panel ◽  
Study Investigator ◽  
The Us ◽  
And Gender ◽  
Research Grant

Abstract Background Black and Hispanic/Latinx gay and other men who have sex with men (MSM), transgender women (TGW), transgender men (TGM), and gender nonbinary individuals (GNB) have been historically underrepresented in HIV prevention trials despite being disproportionately affected by the disease. Therefore, studies of pre-exposure prophylaxis (PrEP), a highly effective intervention for reducing HIV incidence, should include these individuals, and doing so would promote generalizability of the findings. Methods PURPOSE 2 (GS-US-528-9023) will evaluate a twice-yearly long-acting subcutaneous, first in class capsid inhibitor, lenacapavir, for PrEP in MSM, TGW, TGM, and GNB in the US, Brazil, Peru, and South Africa. The study team adopted a multifactorial approach to address historic underrepresentation. This included a literature review to assess successful evidence-based approaches for increasing enrollment of Black and Hispanic/ LatinX MSM, TG, and GNB individuals. We engaged with community and patient advocates as well as key stakeholders to solicit feedback prior to protocol development. Results We established a trial-specific Global Community Advisory Group and implemented their recommendations for site selection, investigator and staff diversity, and strong linkage with community-based organizations. We recruited new community-based research sites and principal investigators (PIs) to mirror historically underrepresented populations and emphasized mentorship of junior sub-Is by seasoned PIs to support enrollment and retention. We developed required trainings for all study and site staff on good participatory practices for PrEP, anti-racism and transgender cultural humility. We established recruitment goals of 50% Black and 20% Hispanic/LatinX MSM in the US, and 20% TGW study-wide. Our strategy to ensure achievement of these overall goals involves nuanced site-specific recruitment goals considering site capacity, local demographics, and HIV incidence data. We will review metrics weekly during enrollment and make any necessary adjustments. Conclusion Using novel approaches, we have carefully chosen with whom, where, and how we will collaborate to increase the diversity, equity, and inclusion in the PURPOSE 2 trial. Disclosures Michelle Cespedes, MD, MS, Gilead Sciences Inc. (Scientific Research Study Investigator, Advisor or Review Panel member, Research Grant or Support)GlaxoSmithKline (Scientific Research Study Investigator, Research Grant or Support) Jill Blumenthal, MD, Gilead Sciences (Grant/Research Support, Scientific Research Study Investigator) Karam Mounzer, MD, Epividian (Advisor or Review Panel member)Gilead Sciences Inc. (Consultant, Scientific Research Study Investigator, Research Grant or Support, Speaker’s Bureau)Janssen (Consultant, Research Grant or Support, Speaker’s Bureau)Merck (Research Grant or Support, Speaker’s Bureau)ViiV Healthcare (Consultant, Speaker’s Bureau) Moti Ramgopal, MD FACP FIDSA, Abbvie (Scientific Research Study Investigator, Speaker’s Bureau)Gilead (Consultant, Scientific Research Study Investigator, Speaker’s Bureau)Janssen (Consultant, Scientific Research Study Investigator, Research Grant or Support, Speaker’s Bureau)Merck (Consultant, Scientific Research Study Investigator)ViiV (Consultant, Scientific Research Study Investigator, Speaker’s Bureau) Ayana Elliott, DNP, APRN, FNP-C, NEA-BC, Gilead Sciences Inc. (Employee, Shareholder) A.C. Demidont, MD, Gilead Sciences Inc. (Employee, Shareholder) C. Chauncey Watson, MD, Gilead Sciences Inc. (Employee, Shareholder) Christoph C. Carter, MD, Gilead Sciences Inc. (Employee, Shareholder) Alex Kintu, MD, ScD, Gilead Sciences Inc. (Employee, Shareholder) Moupali Das, MD, Gilead Sciences Inc. (Employee, Shareholder) Jared Baeten, MD, PHD, Gilead Sciences Inc. (Employee, Shareholder) Onyema Ogbuagu, MD, Gilead Sciences Inc. (Scientific Research Study Investigator, Advisor or Review Panel member, Research Grant or Support, Other Financial or Material Support)ViiV Healthcare (Advisor or Review Panel member)

scholarly journals Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)

2002 ◽  
Vol 3 (5) ◽  
pp. 295-298 ◽  
Author(s):  
M V Downer ◽  
T Hodge ◽  
D K Smith ◽  
S H Qari ◽  
P Schuman ◽  
...  
Keyword(s):  
Regional Variation ◽  
Research Study ◽  
Gene Distribution ◽  
Hiv Epidemiology ◽  
The Us

scholarly journals Representation of US, Pakistani Government and its Military after the Operation ‘Neptune Spear’ in The New York Times and The Guardian

2021 ◽  
Vol IV (III) ◽  
pp. 10-19
Author(s):  
Amir Hamza Marwan ◽  
Danish Baber ◽  
Khayam Hassan
Keyword(s):  
New York ◽  
Content Analysis ◽  
Research Study ◽  
New York Times ◽  
Military Intelligence ◽  
Quantitative Content Analysis ◽  
The New York Times ◽  
Quantitative Content ◽  
The Us ◽  
The Guardian

This research study looks at the representation of USand Pakistani governments and their military in the coverage of TheNew York Times and The Guardian after the Abbottabad Operation.The coverage of these two newspapers has been studied for theconsecutive ten days. The aim is to show that whether these twonewspapers stayed critical or friendly of the Pakistani and the USgovernments? Will it also demonstrate that was the Pakistanigovernment criticized more in the coverage than its military? Thefindings, based on the Quantitative Content Analysis, demonstratethat The New York Times was more critical of the Pakistanigovernment than The Guardian. It further shows that both thenewspapers criticized the Pakistani military/ Intelligence Agenciesmore than the Pakistani government. The findings also reveal thatboth the newspapers appreciated the US in their coverage.

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