scholarly journals Substance P provoked gamma-aminobutyric acid release from the myenteric plexus of the guinea-pig small intestine.

1985 ◽  
Vol 362 (1) ◽  
pp. 319-329 ◽  
Author(s):  
C Tanaka ◽  
K Taniyama
Keyword(s):  
Small Intestine ◽  
Substance P ◽  
Guinea Pig ◽  
Myenteric Plexus ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Acid Release

Autoreceptors regulate γ-[3H]aminobutyric acid release from the guinea pig small intestine

1985 ◽  
Vol 55 (2) ◽  
pp. 245-248 ◽  
Author(s):  
Kohtaro Taniyama ◽  
Susumu Hanada ◽  
Chikako Tanaka
Keyword(s):  
Small Intestine ◽  
Guinea Pig ◽  
Aminobutyric Acid ◽  
Acid Release

Shapes and projections of neurons with immunoreactivity for gamma-aminobutyric acid in the guinea-pig small intestine

1989 ◽  
Vol 256 (2) ◽  
Author(s):  
J.B. Furness ◽  
D.C. Trussell ◽  
S. Pompolo ◽  
J.C. Bornstein ◽  
B.E. Maley ◽  
...  
Keyword(s):  
Small Intestine ◽  
Guinea Pig ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid

The action of substance P on neurons of the myenteric plexus of the guinea-pig small intestine

1979 ◽  
Vol 206 (1163) ◽  
pp. 191-208 ◽  
Keyword(s):  
Small Intestine ◽  
Substance P ◽  
Guinea Pig ◽  
Myenteric Plexus ◽  
Reversal Potential ◽  
Membrane Depolarization ◽  
Extracellular Potassium ◽  
Membrane Hyperpolarization ◽  
Myenteric Neurons

Extracellular and intracellular recordings were made in vitro from single neurons of the myenteric plexus of the guinea-pig small intestine. Synthetic substance P was applied to the neurons by means of the perfusing solution or by electrophoresis from micropipettes. Extracellular recording showed that substance P (100 pM-30 nM), applied by perfusion, increased the firing rate of myenteric neurons. Intracellular recording indicated that perfusion with substance P caused a dose-dependent membrane depolarization which was unaffected by hexamethonium, hyoscine, naloxone or baclofen. The depolarization was also evoked by electrophoretic application of substance P. It was associated with an increase in membrane resistance, augmented by membrane depolarization and reduced by membrane hyperpolarization. The relation between the substance P reversal potential and the logarithm of the extracellular potassium concentration was linear with a slope of 54 mV/log 10 [K + ], which indicates that substance P inactivates the resting potassium conductance of the myenteric neurons. This effect on ion conductance is the same as that of an unknown substance that mediates slow synaptic excitations with the myenteric plexus.

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