Pressure Increases Inert Particle Uptake in Human Saphenous Vein

2000 ◽  
Author(s):  
M. J. MacLennan ◽  
B. J. Leavitt ◽  
J. D. Schmoker ◽  
N. C. Chesler
Keyword(s):  
Saphenous Vein ◽  
Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Coronary Bypass ◽  
The United States ◽  
Human Saphenous Vein ◽  
Particle Uptake ◽  
Internal Mammary

Abstract Cardiovascular disease is one of the leading causes of death in the United States, and coronary artery bypass graft surgery (CABG) is one of the mainstays of treatment for this disease (Niklason et al., 1999). Since artificial vascular grafts suitable for coronary bypass are not yet available, the autologous internal mammary artery (IMA) and saphenous vein are used to bypass diseased tissue (Niklason et al., 1999). While IMA grafts have high long-term patency rates, a saphenous vein grafted into the arterial position tends to stenose and eventually thrombose.

Pressure Increases Inert Particle Uptake in Human Saphenous Vein

2000 ◽  
Author(s):  
M. J. MacLennan ◽  
B. J. Leavitt ◽  
J. D. Schmoker ◽  
N. C. Chesler
Keyword(s):  
Saphenous Vein ◽  
Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Coronary Bypass ◽  
The United States ◽  
Human Saphenous Vein ◽  
Particle Uptake ◽  
Internal Mammary

Abstract Cardiovascular disease is one of the leading causes of death in the United States, and coronary artery bypass graft surgery (CABG) is one of the mainstays of treatment for this disease [1]. Since artificial vascular grafts suitable for coronary bypass are not yet available, autologous internal mammary artery (IMA) and saphenous vein are used to bypass diseased tissue [1]. While IMA grafts have high long-term patency rates, saphenous vein grafted into the arterial position tends to stenose and eventually thrombose.

scholarly journals Long-term (5 to 12 years) serial studies of internal mammary artery and saphenous vein coronary bypass grafts

1985 ◽  
Vol 89 (2) ◽  
pp. 248-258 ◽  
Author(s):  
Bruce W. Lytle ◽  
Floyd D. Loop ◽  
Delos M. Cosgrove ◽  
Norman B. Ratliff ◽  
K!rk Easley ◽  
...  
Keyword(s):  
Saphenous Vein ◽  
Internal Mammary Artery ◽  
Coronary Bypass ◽  
Bypass Grafts ◽  
Coronary Bypass Grafts ◽  
Internal Mammary

Coronary artery bypass graft: why is the saphenous vein prone to intimal hyperplasia?

2014 ◽  
Vol 92 (7) ◽  
pp. 531-545 ◽  
Author(s):  
Swastika Sur ◽  
Jeffrey T. Sugimoto ◽  
Devendra K. Agrawal
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Saphenous Vein ◽  
Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft ◽  
Internal Mammary

Proliferation and migration of smooth muscle cells and the resultant intimal hyperplasia cause coronary artery bypass graft failure. Both internal mammary artery and saphenous vein are the most commonly used bypass conduits. Although an internal mammary artery graft is immune to restenosis, a saphenous vein graft is prone to develop restenosis. We found significantly higher activity of phosphatase and tensin homolog (PTEN) in the smooth muscle cells of the internal mammary artery than in the saphenous vein. In this article, we critically review the pathophysiology of vein-graft failure with detailed discussion of the involvement of various factors, including PTEN, matrix metalloproteinases, and tissue inhibitor of metalloproteinases, in uncontrolled proliferation and migration of smooth muscle cells towards the lumen, and invasion of the graft conduit. We identified potential target sites that could be useful in preventing and (or) reversing unwanted consequences following coronary artery bypass graft using saphenous vein.

scholarly journals Topical Vasodilator Response is Significantly Higher in Skeletonized Internal Mammary Artery

2016 ◽  
Vol 9 (4) ◽  
pp. 279
Author(s):  
Nida Butt ◽  
Sarah Hamid ◽  
Mujtaba Hussain ◽  
Ali Alam ◽  
Hala Soomro ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Internal Mammary Artery ◽  
Left Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Internal Mammary ◽  
The Difference

<p><strong>AIM OF THE STUDY</strong><strong>:</strong> Coronary artery bypass graft surgery is the gold standard for the treatment of multi-vessel and left main coronary artery disease. However, there is considerable debate that whether left internal mammary artery (IMA) should be taken as pedicled or skeletonized. This study was conducted to assess the difference in blood flow after application of topical vasodilator in skeletonized and pedicled IMA.</p><p><strong>METHODS</strong><strong>: </strong>In this study, each patient underwent either skeletonized (n=25) or pedicled IMA harvesting (n=25). The type of graft on each individual patient was decided randomly. Intra-operative variables such as conduit length and blood flow were measured by the surgeon himself. The length of the grafted IMA was carefully determined in-vivo, with the proximal and distal ends attached, from the first rib to IMA divergence. The IMA flow was measured on two separate occasions; before and after application of topical vasodilator.  Known cases of subclavian artery stenosis and previous sternal radiation were excluded from the study.</p><p><strong>RESULTS</strong><strong>:</strong> The blood flow before application of topical vasodilator was similar in both the groups (<em>P</em>=0.227). However, the flow was significantly less in pedicled than skeletonized IMA after application of vasodilator (<em>P</em> &lt; 0.0001). Similarly, the length of skeletonized graft was significantly higher than the length of pedicled graft (<em>P</em> &lt; 0.0001).</p><p><strong>CONCLUSION</strong><strong>:</strong> Our study signifies that skeletonization of IMA results in increased graft length and blood flow especially after the application of topical vasodilator. However, we recommend that long term clinical trials should be conducted to fully determine long term patency rates of skeletonized IMA.</p>

Biology of bypass vessels and their relation to patency and disease

2021 ◽  
pp. 23-30
Author(s):  
Thomas F. Lüscher
Keyword(s):  
Coronary Artery ◽  
Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Coronary Bypass ◽  
Artery Bypass Graft ◽  
Bypass Grafts ◽  
Current Standard ◽  
Internal Mammary ◽  
The Right

Current standard surgical technique in patients undergoing coronary bypass grafting involves the use of an internal mammary artery (also known as an internal thoracic artery) bypass graft, in general to the left anterior descending coronary artery, and in many centres also the use of the right internal mammary artery to the right coronary artery. Several clinical studies have shown the superiority of mammary artery bypass grafts for survival of patients compared to the use of venous bypass grafts alone. Indeed, the internal mammary artery has several biological features, discussed in this chapter, that are remarkable and of great interest for biologists, cardiologists, and surgeons alike.

Internal Mammary Artery Bypass Graft—Long-term Patency Rate and Follow-up

1974 ◽  
Vol 18 (3) ◽  
pp. 269-279 ◽  
Author(s):  
Earle B. Kay ◽  
H. Naraghipour ◽  
R.A. Beg ◽  
M. DeManey ◽  
A. Tambe ◽  
...  
Keyword(s):  
Patency Rate ◽  
Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft ◽  
Internal Mammary
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