scholarly journals Laser speckle contrast imaging of cerebral blood flow in freely moving animals

2011 ◽  
Vol 16 (9) ◽  
pp. 090502 ◽  
Author(s):  
Peng Miao ◽  
Hongyang Lu ◽  
Qi Liu ◽  
Yao Li ◽  
Shanbao Tong
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Laser Speckle ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast ◽  
Freely Moving

Intraoperative laser speckle contrast imaging for monitoring cerebral blood flow: results from a 10-patient pilot study

2012 ◽  
Author(s):  
Lisa M. Richards ◽  
Erica L. Weber ◽  
Ashwin B. Parthasarathy ◽  
Kaelyn L. Kappeler ◽  
Douglas J. Fox ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pilot Study ◽  
Laser Speckle ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast

Laser speckle contrast imaging of cerebral blood flow in humans during neurosurgery: a pilot clinical study

2010 ◽  
Vol 15 (6) ◽  
pp. 066030 ◽  
Author(s):  
Ashwin B. Parthasarathy ◽  
Erica L. Weber ◽  
Lisa M. Richards ◽  
Douglas J. Fox ◽  
Andrew K. Dunn
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Clinical Study ◽  
Laser Speckle ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast ◽  
Pilot Clinical Study

scholarly journals Real-time quantitative monitoring of cerebral blood flow by laser speckle contrast imaging after cardiac arrest with targeted temperature management

2017 ◽  
Vol 39 (6) ◽  
pp. 1161-1171 ◽  
Author(s):  
Junyun He ◽  
Hongyang Lu ◽  
Leanne Young ◽  
Ruoxian Deng ◽  
Daniel Callow ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Arrest ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Laser Speckle ◽  
Targeted Temperature Management ◽  
Temperature Management ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast

Brain injury is the main cause of mortality and morbidity after cardiac arrest (CA). Changes in cerebral blood flow (CBF) after reperfusion are associated with brain injury and recovery. To characterize the relative CBF (rCBF) after CA, 14 rats underwent 7 min asphyxia-CA and were randomly treated with 6 h post-resuscitation normothermic (36.5–37.5℃) or hypothermic- (32–34℃) targeted temperature management (TTM) (N = 7). rCBF was monitored by a laser speckle contrast imaging (LSCI) technique. Brain recovery was evaluated by neurologic deficit score (NDS) and quantitative EEG – information quantity (qEEG-IQ). There were regional differences in rCBF among veins of distinct cerebral areas and heterogeneous responses among the three components of the vascular system. Hypothermia immediately following return of spontaneous circulation led to a longer hyperemia duration (19.7 ± 1.8 vs. 12.7 ± 0.8 min, p < 0.01), a lower rCBF (0.73 ± 0.01 vs. 0.79 ± 0.01; p < 0.001) at the hypoperfusion phase, a better NDS (median [25th–75th], 74 [61–77] vs. 49 [40–77], p < 0.01), and a higher qEEG-IQ (0.94 ± 0.02 vs. 0.77 ± 0.02, p < 0.001) compared with normothermic TTM. High resolution LSCI technique demonstrated hypothermic TTM extends hyperemia duration, delays onset of hypoperfusion phase and lowered rCBF, which is associated with early restoration of electrophysiological recovery and improved functional outcome after CA.

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