scholarly journals The influence of droplet concentration on phase change and inertial cavitation thresholds associated with acoustic droplet vaporization

2020 ◽  
Vol 148 (4) ◽  
pp. EL375-EL381
Author(s):  
Yanye Yang ◽  
Dongxin Yang ◽  
Qi Zhang ◽  
Xiasheng Guo ◽  
Jason L. Raymond ◽  
...  
Keyword(s):  
Phase Change ◽  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Inertial Cavitation ◽  
Droplet Concentration

scholarly journals From Micro- to Nano-Multifunctional Theranostic Platform: Effective Ultrasound Imaging Is Not Just a Matter of Scale

2018 ◽  
Vol 17 ◽  
pp. 153601211877821 ◽  
Author(s):  
Sara Zullino ◽  
Monica Argenziano ◽  
Ilaria Stura ◽  
Caterina Guiot ◽  
Roberta Cavalli
Keyword(s):  
Diagnostic Imaging ◽  
Phase Change ◽  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Tumor Tissue ◽  
Ultrasound Contrast Agents ◽  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Enhanced Permeability And Retention ◽  
Ultrasound Contrast

Ultrasound Contrast Agents (UCAs) consisting of gas-filled-coated Microbubbles (MBs) with diameters between 1 and 10 µm have been used for a number of decades in diagnostic imaging. In recent years, submicron contrast agents have proven to be a viable alternative to MBs for ultrasound (US)-based applications for their capability to extravasate and accumulate in the tumor tissue via the enhanced permeability and retention effect. After a short overview of the more recent approaches to ultrasound-mediated imaging and therapeutics at the nanoscale, phase-change contrast agents (PCCAs), which can be phase-transitioned into highly echogenic MBs by means of US, are here presented. The phenomenon of acoustic droplet vaporization (ADV) to produce bubbles is widely investigated for both imaging and therapeutic applications to develop promising theranostic platforms.

scholarly journals Hemolysis resulting from acoustic droplet vaporization and inertial cavitation

2019 ◽  
Author(s):  
Newsha Jahanpanah ◽  
Sneha Sharma ◽  
Karla P. Mercado-Shekhar ◽  
Haili Su ◽  
Hunter A. Palcich ◽  
...  
Keyword(s):  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Inertial Cavitation

scholarly journals Synchronized Optical and Acoustic Droplet Vaporization for Effective Sonoporation

Pharmaceutics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 279 ◽  
Author(s):  
Wei-Wen Liu ◽  
Sy-Han Huang ◽  
Pai-Chi Li
Keyword(s):  
Laser Power ◽  
Continuous Wave ◽  
Synergistic Effects ◽  
Tumor Therapy ◽  
Average Power ◽  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Inertial Cavitation ◽  
Cw Laser ◽  
Ultrasound Pulse

Inertial cavitation-based sonoporation has been utilized to enhance treatment delivery efficacy. In our previous study, we demonstrated that tumor therapeutic efficacy can be enhanced through vaporization-assisted sonoporation with gold nanodroplets (AuNDs). Specifically, the AuNDs were vaporized both acoustically (i.e., acoustic droplet vaporization, ADV) and optically (i.e., optical droplet vaporization, ODV). A continuous wave (CW) laser was used for ODV in combination with an ultrasound pulse for ADV. Although effective for vaporization, the use of a CW laser is not energy efficient and may create unwanted heating and concomitant tissue damage. In this study, we propose the use of a pulsed wave (PW) laser to replace the CW laser. In addition, the PW laser was applied at the rarefaction phase of the ultrasound pulse so that the synergistic effects of ADV and ODV can be expected. Therefore, a significantly lower laser average power can be expected to achieve the vaporization threshold. Compared to the CW laser power at 2 W/cm2 from the previous approach, the PW laser power was reduced to only 0.2404 W/cm2. Furthermore, we also demonstrate in vitro that the sonoporation rate was increased when the PW laser was applied at the rarefaction phase. Specifically, the vaporization signal, the inertial cavitation signal, and the sonoporation rate all displayed a 1-µs period, which corresponded to the period of the 1-MHz acoustic wave used for ADV, as a function of the relative laser delay. The increased sonoporation rate indicates that this technique has the potential to enhance sonoporation-directed drug delivery and tumor therapy with a lower laser power while keeping the cell death rate at the minimum. Photoacoustic imaging can also be performed at the same time since a PW laser is used for the ODV.

Flow-Independent Microbubble Isolation by Rapid Recondensation of Phase-Change Nanodrops after Acoustic Droplet Vaporization

2021 ◽  
Author(s):  
Mark T. Burgess ◽  
Jeffrey A. Ketterling ◽  
Mitra Aliabouzar ◽  
Christian Aguilar ◽  
Mario L. Fabiilli
Keyword(s):  
Phase Change ◽  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization

The role of inertial cavitation in acoustic droplet vaporization

2008 ◽  
Author(s):  
Mario L. Fabiilli ◽  
Kevin J. Haworth ◽  
Oliver D. Kripfgans ◽  
Paul L. Carson ◽  
J. Brian Fowlkes
Keyword(s):  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Inertial Cavitation

scholarly journals The role of inertial cavitation in acoustic droplet vaporization

2009 ◽  
Vol 56 (5) ◽  
pp. 1006-1017 ◽  
Author(s):  
M.L. Fabiilli ◽  
K.J. Haworth ◽  
N.H. Fakhri ◽  
O.D. Kripfgans ◽  
P.L. Carson ◽  
...  
Keyword(s):  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Inertial Cavitation
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