The Effect of 1 Week of a Multi-ingredient Dietary Preworkout Supplement on Resting and Postacute Resistance Exercise Vascular Function

2018 ◽  
Vol 28 (6) ◽  
pp. 611-618
Author(s):  
Austin T. Robinson ◽  
Adriana Mazzuco ◽  
Ahmad S. Sabbahi ◽  
Audrey Borghi-Silva ◽  
Shane A. Phillips
2011 ◽  
Vol 110 (4) ◽  
pp. 1013-1020 ◽  
Author(s):  
Shane A. Phillips ◽  
Emon Das ◽  
Jingli Wang ◽  
Kirkwood Pritchard ◽  
David D. Gutterman

Resistance and aerobic exercise is recommended for cardiovascular health and disease prevention. However, the accompanying increase in arterial pressure during resistance exercise may be detrimental to vascular health. This study tests the vascular benefits of aerobic compared with resistance exercise on preventing impaired vascular function induced by a single weight lifting session that is associated with acute hypertension. Healthy, lean sedentary (SED) subjects, weight lifters, runners (>15 miles/wk), and cross trainers (chronic aerobic and resistance exercisers), underwent a single progressive leg press weight lifting session with blood pressure measurements. Brachial artery flow-mediated vasodilation (FMD; an index of arterial endothelial function) was determined using ultrasonography immediately before and after weight lifting. Sublingual nitroglycerin (0.4 mg) was used to determine endothelium-independent dilation after weight lifting. All subjects were normotensive with similar blood pressure responses during exercise. Baseline FMD was lower in runners (5.4 ± 0.5%; n = 13) and cross trainers (4.44 ± 0.3%; n = 13) vs. SED (8.5 ± 0.8%; n = 13; P = 0.037). Brachial FMD improved in conditioned weight lifters (to 8.8 ± 0.9%; P = 0.007) and runners (to 7.6 ± 0.6%; P < 0.001) but not cross trainers (to 5.3 ± 0.6%; P = NS) after acute hypertension. FMD was decreased in SED (to 5.7 ± 0.4%; P = 0.019). Dilation to nitroglycerin was similar among groups. These data suggest that endothelial responses are maintained after exposure to a single bout of weight lifting in resistance and aerobic athletes. Resistance and aerobic exercise may confer similar protection against acute vascular insults such as exertional hypertension.


2015 ◽  
Vol 65 (10) ◽  
pp. A292
Author(s):  
Gerasimos Siasos ◽  
Dimitrios Athanasiou ◽  
Gerasimos Terzis ◽  
Aggeliki Stasinaki ◽  
Panagiotis Tourikis ◽  
...  

2001 ◽  
Vol 38 (3) ◽  
pp. 860-866 ◽  
Author(s):  
Andrew Maiorana ◽  
Gerard O’Driscoll ◽  
Craig Cheetham ◽  
Lawrence Dembo ◽  
Kim Stanton ◽  
...  

2012 ◽  
Vol 112 (3) ◽  
pp. 347-353 ◽  
Author(s):  
Bethan Phillips ◽  
John Williams ◽  
Philip Atherton ◽  
Kenneth Smith ◽  
Wulf Hildebrandt ◽  
...  

One manifestation of age-related declines in vascular function is reduced peripheral (limb) blood flow and vascular conduction at rest and in response to vasodilatory stimuli such as exercise and feeding. Since, even in older age, resistance exercise training (RET) represents an efficacious strategy for increasing muscle mass and function, we hypothesized that likewise RET would improve age-related declines in leg blood flow (LBF) and vascular conductance (LVC). We studied three mixed-sex age groups (young: 18–28 yr, n = 14; middle aged: 45–55 yr, n = 20; older: 65–75 yr, n = 17) before and after 20 wk of whole body RET in the postabsorptive state (BASAL) and after unilateral leg extensions (6 × 8 repetitions; 75% 1 repetition maximum) followed by intermittent mixed-nutrient liquid feeds (∼6.5 kJ·kg−1·30 min−1), which allowed us to discern the acute effects of feeding (nonexercised leg; FED) and exercise plus feeding (exercised leg; FEDEX) on vascular function. We measured LBF using Doppler ultrasound and recorded mean arterial pressure (MAP) to calculate LVC. Our results reveal that although neither age nor RET influenced BASAL LBF, age-related declines in LBF responses to FED were eradicated by RET. Moreover, increases in LBF after FEDEX, which occurred only in young and middle-aged groups before RET (+73 ± 9%, and +90 ± 13%, P < 0.001, respectively), increased in all groups after RET (young +78 ± 10%, middle-aged +96 ± 15%, older +80 ± 19%, P < 0.001). Finally, RET robustly improved LVC under FASTED, FED, and FEDEX conditions in the older group. These data provide novel information that supports the premise that RET represents a valuable strategy to counter age-related impairments in LBF/LVC.


2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Lia R Servidio ◽  
Sally A. Roberts ◽  
Mary L. Laycock ◽  
M. Brennan Harris

Author(s):  
Adam T. Corkery ◽  
Anna J. Howery ◽  
Kathleen B. Miller ◽  
Jill N. Barnes

Diminished cerebrovascular function is associated with reduced cognitive ability. Habitual exercise may maintain or improve cerebrovascular function; however, limited information exists regarding the optimal exercise prescription for cerebrovascular health. While aerobic exercise is associated with improved systemic vascular function, the influence of resistance exercise on vascular health is unclear. Therefore, the purpose of this study was to examine the influence of habitual exercise training on cerebrovascular function in healthy young adults. We evaluated 13 untrained (age = 27 ± 5 yr; 11 men, 2 women), 13 aerobic trained (age = 28 ± 5 yr; 10 men, 3 women), and 13 resistance trained (age = 24 ± 4 yr; 11 men, 2 women) adults. Middle cerebral artery velocity (MCAv), mean arterial pressure (MAP), and end-tidal carbon dioxide (ETCO2) were continuously measured at rest, and in response to hypercapnia. At rest, there were no differences between groups for MCAv; however, resistance trained adults had greater cerebrovascular conductance compared with aerobic trained adults (0.79 ± 0.26 cm/s/mmHg vs. 0.56 ± 0.17 cm/s/mmHg; p < 0.05). In response to hypercapnia, cerebrovascular reactivity and MAP reactivity were not different between groups. There was no association between aerobic fitness or measures of exercise volume and any variable of cerebrovascular function in the combined or individual groups. Our results suggest that the mode of exercise training does not impact cerebrovascular reactivity in healthy young adults; however, it may influence resting cerebral hemodynamics. Future research could examine the influence of habitual exercise training on cerebrovascular function with aging.


2018 ◽  
Vol 125 (6) ◽  
pp. 1693-1701 ◽  
Author(s):  
Kerry L. Hildreth ◽  
Robert S. Schwartz ◽  
Joseph Vande Griend ◽  
Wendy M. Kohrt ◽  
Patrick J. Blatchford ◽  
...  

The cardiovascular effects of testosterone (T) are controversial. Low T has been associated with accelerated vascular aging, characterized by large elastic artery stiffening (decreased compliance), intimal-medial thickening (IMT), and endothelial dysfunction. Endurance exercise improves vascular function, but resistance training may increase arterial stiffness. We sought to determine whether T supplementation improved markers of vascular aging in men with low–normal T and whether T supplementation prevented arterial stiffness with resistance exercise. We studied 160 community-dwelling older men (66 ± 5 yr) with low–normal baseline total T levels (200–350 ng/dl). Participants were randomized to transdermal T gel targeting either a lower (400–550 ng/dl) or higher (600–1,000 ng/dl) T range or to placebo gel and to either progressive resistance training (PRT) or to no exercise for 12 mo. Carotid artery stiffness (arterial compliance) and carotid IMT were measured at baseline, 6 mo, and 12 mo. Endothelial function (brachial artery flow-mediated dilation) was measured in a subset ( n = 86). Changes in carotid artery compliance, IMT, and endothelial function with either the lower or higher range of T supplementation were not different from placebo at 6 or 12 mo. There were no differences between PRT and no PRT groups, alone or with T supplementation, in changes in any of the vascular measures at either time point. Supplementation of T and PRT in older men with low–normal levels do not appear to improve or harm vascular function.NEW & NOTEWORTHY Increased promotion and prescription of testosterone (T) to aging men has raised concerns about potential adverse cardiovascular effects. We show that in older men with T levels in the low–normal range, 12 mo of T supplementation with or without resistance exercise did not improve or harm vascular function.


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