Identification of Essential Residues Involved in the Glutamate Binding Pocket of the Group II Metabotropic Glutamate Receptor

Molecular Pharmacology ◽

10.1124/mol.60.5.944 ◽

2001 ◽

Vol 60 (5) ◽

pp. 944-954 ◽

Author(s):

Pari Malherbe ◽

Frédéric Knoflach ◽

Clemens Broger ◽

Serge Ohresser ◽

Claudia Kratzeisen ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Binding Pocket ◽

Metabotropic Glutamate ◽

Glutamate Binding ◽

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Faculty Opinions recommendation of Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1797991.1327096 ◽

2010 ◽

Author(s):

Michael Andresen

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Activation ◽

Metabotropic Glutamate ◽

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The role of NMDA receptors in regulating group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex

Neuropharmacology ◽

10.1016/j.neuropharm.2008.02.013 ◽

2008 ◽

Vol 54 (7) ◽

pp. 1071-1078 ◽

Author(s):

Chiung-Chun Huang ◽

Kuei-Sen Hsu

Keyword(s):

Prefrontal Cortex ◽

Nmda Receptors ◽

Medial Prefrontal Cortex ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Long Term Depression ◽

Metabotropic Glutamate ◽

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LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia

Neuroscience Letters ◽

10.1016/s0304-3940(99)00663-1 ◽

1999 ◽

Vol 273 (3) ◽

pp. 191-194 ◽

Author(s):

Ann Bond ◽

Nella Ragumoorthy ◽

James A. Monn ◽

Caroline A. Hicks ◽

Mark A. Ward ◽

...

Keyword(s):

Glutamate Receptor ◽

Cerebral Ischaemia ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Focal Cerebral Ischaemia ◽

Metabotropic Glutamate ◽

Group Ii ◽

Glutamate Receptor Agonist

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Association analysis of Group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2009.04.007 ◽

2009 ◽

Vol 33 (5) ◽

pp. 875-879 ◽

Author(s):

Tomoko Tsunoka ◽

Taro Kishi ◽

Masashi Ikeda ◽

Tsuyoshi Kitajima ◽

Yoshio Yamanouchi ◽

...

Keyword(s):

Mood Disorders ◽

Association Analysis ◽

Glutamate Receptor ◽

Japanese Population ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

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Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: The impact of cell differentiation state

Neuropharmacology ◽

10.1016/j.neuropharm.2014.03.019 ◽

2014 ◽

Vol 83 ◽

pp. 36-53 ◽

Author(s):

D. Jantas ◽

A. Greda ◽

S. Golda ◽

M. Korostynski ◽

B. Grygier ◽

...

Keyword(s):

Cell Differentiation ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Neuroprotective Effects ◽

Human Neuroblastoma ◽

Metabotropic Glutamate ◽

Group Ii ◽

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Probing the Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations That Engender a “Molecular Switch” in PAM Pharmacology

Molecular Pharmacology ◽

10.1124/mol.112.083949 ◽

2013 ◽

Vol 83 (5) ◽

pp. 991-1006 ◽

Author(s):

Karen J. Gregory ◽

Elizabeth D. Nguyen ◽

Sean D. Reiff ◽

Emma F. Squire ◽

Shaun R. Stauffer ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Point Mutations ◽

Binding Pocket ◽

Molecular Switch ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Actions of group i and group ii metabotropic glutamate receptor ligands on 5-hydroxytryptamine release in the rat cerebral cortex in vivo: differential roles in the regulation of central serotonergic neurotransmission

Neuroscience ◽

10.1016/s0306-4522(02)00837-0 ◽

2003 ◽

Vol 117 (3) ◽

pp. 671-679 ◽

Author(s):

J.J Lee ◽

M.J Croucher

Keyword(s):

Cerebral Cortex ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Rat Cerebral Cortex ◽

Receptor Ligands ◽

Metabotropic Glutamate ◽

Serotonergic Neurotransmission ◽

Group I ◽

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Group II metabotropic glutamate receptor antagonism prevents the antiallodynic effects of R-isovaline

Neuroscience ◽

10.1016/j.neuroscience.2015.02.022 ◽

2015 ◽

Vol 293 ◽

pp. 151-156 ◽

Author(s):

K.A. Asseri ◽

E. Puil ◽

S.K.W. Schwarz ◽

B.A. MacLeod

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Antagonism ◽

Metabotropic Glutamate ◽

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Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

10.1126/science.281.5381.1349 ◽

1998 ◽

Vol 281 (5381) ◽

pp. 1349-1352 ◽

Author(s):

B. Moghaddam

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Group Ii ◽

Glutamate Receptor Agonist

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Repeated Cocaine Administration Impairs Group II Metabotropic Glutamate Receptor-Mediated Long-Term Depression in Rat Medial Prefrontal Cortex

Journal of Neuroscience ◽

10.1523/jneurosci.4247-06.2007 ◽

2007 ◽

Vol 27 (11) ◽

pp. 2958-2968 ◽

Author(s):

C.-C. Huang ◽

P.-C. Yang ◽

H.-J. Lin ◽

K.-S. Hsu

Keyword(s):

Prefrontal Cortex ◽

Medial Prefrontal Cortex ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Long Term Depression ◽

Cocaine Administration ◽

Metabotropic Glutamate ◽

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