Activation of the Mitogen Activated Protein Kinase Extracellular Signal-Regulated Kinase 1 and 2 by the Nitric Oxide–cGMP–cGMP-Dependent Protein Kinase Axis Regulates the Expression of Matrix Metalloproteinase 13 in Vascular Endothelial Cells

2002 ◽  
Vol 62 (4) ◽  
pp. 927-935 ◽  
Author(s):  
Carlos Zaragoza ◽  
Estrella Soria ◽  
Esther López ◽  
Darren Browning ◽  
Milagros Balbı́n ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Vascular Endothelial Cells ◽  
Mitogen Activated Protein Kinase ◽  
Vascular Endothelial ◽  
Dependent Protein Kinase ◽  
Extracellular Signal Regulated Kinase ◽  
Matrix Metalloproteinase 13 ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Dependent Protein

scholarly journals ATM and the Catalytic Subunit of DNA-Dependent Protein Kinase Activate NF-κB through a Common MEK/Extracellular Signal-Regulated Kinase/p90rsk Signaling Pathway in Response to Distinct Forms of DNA Damage

2004 ◽  
Vol 24 (5) ◽  
pp. 1823-1835 ◽  
Author(s):  
Ganesh R. Panta ◽  
Swayamjot Kaur ◽  
Lakita G. Cavin ◽  
Maria L. Cortés ◽  
Frank Mercurio ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protein Kinase ◽  
Nuclear Factor Κb ◽  
Catalytic Subunit ◽  
Mitogen Activated Protein Kinase ◽  
Dependent Protein Kinase ◽  
Iκb Kinase ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Dependent Protein

ABSTRACT We have identified a novel pathway of ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK) signaling that results in nuclear factor κB (NF-κB) activation and chemoresistance in response to DNA damage. We show that the anthracycline doxorubicin (DOX) and its congener N-benzyladriamycin (AD 288) selectively activate ATM and DNA-PK, respectively. Both ATM and DNA-PK promote sequential activation of the mitogen-activated protein kinase (MAPK)/p90 rsk signaling cascade in a p53-independent fashion. In turn, p90 rsk interacts with the IκB kinase 2 (IKK-2) catalytic subunit of IKK, thereby inducing NF-κB activity and cell survival. Collectively, our findings suggest that distinct members of the phosphatidylinositol kinase family activate a common prosurvival MAPK/IKK/NF-κB pathway that opposes the apoptotic response following DNA damage.

MEK5/ERK5: Mitogen-Activated Protein Kinase 5/Extracellular Signal-Regulated Kinase 5

2012 ◽  
pp. 1074-1074
Author(s):  
Andreas Gewies ◽  
Jürgen Ruland ◽  
Alexey Kotlyarov ◽  
Matthias Gaestel ◽  
Shiri Procaccia ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Mitogen Activated Protein
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