Long-range attraction and molecular rearrangements in receptor-ligand interactions

Science ◽  
1992 ◽  
Vol 255 (5050) ◽  
pp. 1419-1421 ◽  
Author(s):  
D. Leckband ◽  
J. Israelachvili ◽  
F. Schmitt ◽  
W Knoll
Keyword(s):  
Long Range ◽  
Receptor Ligand ◽  
Molecular Rearrangements ◽  
Ligand Interactions

Modulation of Platelet Activation by Native DNA – Initial Description of Platelet Receptor Type, Number and Discrimination for Native DNA

1981 ◽  
Vol 45 (03) ◽  
pp. 263-266 ◽  
Author(s):  
B A Fiedel ◽  
M E Frenzke
Keyword(s):  
Platelet Aggregation ◽  
Human Platelets ◽  
Scatchard Analysis ◽  
Type Number ◽  
Single Class ◽  
Receptor Ligand ◽  
Platelet Receptor ◽  
Platelet Binding ◽  
Ligand Interactions ◽  
Initial Description

SummaryNative DNA (dsDNA) induces the aggregation of isolated human platelets. Using isotopically labeled dsDNA (125I-dsDNA) and Scatchard analysis, a single class of platelet receptor was detected with a KD = 190 pM and numbering ~275/platelet. This receptor was discriminatory in that heat denatured dsDNA, poly A, poly C, poly C · I and poly C · poly I failed to substantially inhibit either the platelet binding of, or platelet aggregation induced by, dsDNA; by themselves, these polynucleotides were ineffective as platelet agonists. However, poly G, poly I and poly G · I effectively and competitively inhibited platelet binding of the radioligand, independently activated the platelet and when used at a sub-activating concentration decreased the extent of dsDNA stimulated platelet aggregation. These data depict a receptor on human platelets for dsDNA and perhaps certain additional polynucleotides and relate receptor-ligand interactions to a physiologic platelet function.

scholarly journals Helix-mediated over 1 nm-range chirality recognition by ligand-to-ligand interactions of dinuclear helicates

2021 ◽  
Author(s):  
Natsumi Suko ◽  
Hideki Itamoto ◽  
Yoshinori Okayasu ◽  
Naoya Okura ◽  
Junpei Yuasa
Keyword(s):  
Long Range ◽  
Lanthanide Complexes ◽  
Ligand Interactions ◽  
Nm Range

Long-range chirality recognition between the two chiral guest ligands can be tuned based on the helix distance (dLn-Ln = 11.5 and 14.0 Å) of bis-diketonate bridged dinuclear lanthanide complexes (2Th...

scholarly journals Detection of weak receptor-ligand interactions using IgM and J-chain-based fusion proteins

2012 ◽  
Vol 42 (5) ◽  
pp. 1354-1356 ◽  
Author(s):  
Johannes U. Ammann ◽  
Martin Jahnke ◽  
Michael R. Dyson ◽  
Jim Kaufman ◽  
John Trowsdale
Keyword(s):  
Fusion Proteins ◽  
Receptor Ligand ◽  
J Chain ◽  
Ligand Interactions
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