[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] The increase of data-intensive applications in science and engineering fields (i.e., bioinformatics, cybermanufacturing) demand the use of high-performance computing resources. However, data-intensive applications' local resources usually present limited capacity and availability due to sizable upfront costs. Moreover, using remote public resources presents constraints at the private edge network domain. Specifically, mis-configured network policies cause bottlenecks due to the other application cross-traffic attempting to use shared networking resources. Additionally, selecting the right remote resources can be cumbersome especially for those users who are interested in the application execution considering nonfunctional requirements such as performance, security and cost. The data-intensive applications have recurrent deployments and similar infrastructure requirements that can be addressed by creating templates. In this thesis, we handle applications requirements through intelligent resource 'abstractions' coupled with 'reusable' approaches that save time and effort in deploying new cloud architectures. Specifically, we design a novel custom template middleware that can retrieve blue prints of resource configuration, technical/policy information, and benchmarks of workflow performance to facilitate repeatable/reusable resource composition. The middleware considers hybrid-recommendation methodology (Online and offline recommendation) to leverage a catalog to rapidly check custom template solution correctness before/during resource consumption. Further, it prescribes application adaptations by fostering effective social interactions during the application's scaling stages. Based on the above approach, we organize the thesis contributions under two main thrusts: (i) Custom Templates for Cloud Networking for Data-intensive Applications: This involves scheduling transit selection, engineering at the campus-edge based upon real-time policy control. Our solution ensures prioritized application performance delivery for multi-tenant traffic profiles from a diverse set of actual data intensive applications in bioinformatics. (ii) Custom Templates for Cloud Computing for Data-intensive Applications: This involves recommending cloud resources for data-intensive applications based on a custom template catalog. We develop a novel expert system approach that is implemented as a middleware to abstracts data-intensive application requirements for custom templates composition. We uniquely consider heterogeneous cloud resources selection for the deployment of cloud architectures for real data-intensive applications in cybermanufacturing.