scholarly journals Effect of HSR-903, a New Fluoroquinolone, on the Concentration of Theophylline in Serum

1999 ◽  
Vol 43 (6) ◽  
pp. 1494-1496 ◽  
Author(s):  
Yoshihito Niki ◽  
Shinsuke Watanabe ◽  
Sadao Tamada ◽  
Koichiro Yoshida ◽  
Naoyuki Miyashita ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Excretion Rates

ABSTRACT The effect of HSR-903, a new fluoroquinolone, on the concentration of theophylline in serum in healthy male volunteers was investigated. The concentration of theophylline in serum and the urinary excretion rates of theophylline on day 5 of concomitant dosing with HSR-903 tended to increase compared to those on day 4, when theophylline was given alone; however, the urinary excretion rates of 1-methyluric acid and 3-methylxanthine on day 5 of concomitant dosing with HSR-903 tended to decrease in comparison to those on day 4, when theophylline was given alone.

Excretion of 2- and 3-monomethyl ethers of 2-hydroxyestrogens in healthy male volunteers

1996 ◽  
Vol 135 (2) ◽  
pp. 193-197 ◽  
Author(s):  
Markus Banger ◽  
Christoph Hiemke ◽  
Margitta Haupt ◽  
Rudolf Knuppen
Keyword(s):  
In Vivo Studies ◽  
Estrogen Metabolism ◽  
Minor Importance ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Major Route ◽  
Excretion Rates

Banger M, Hiemke C, Haupt M, Knuppen R. Excretion of 2- and 3-monomethyl ethers of 2-hydroxyestrogens in healthy male volunteers. Eur J Endocrinol 1996;135:193–7. ISSN 0804–4643 The formation of catecholestrogens by 2-and 4-hydroxylation of monophenolic estrogens represents a major route of estrogen metabolism. In vitro and in vivo studies on catecholestrogens have shown that 2-hydroxylated catecholestrogens are primarily inactivated by O-methylation, while O-methylation of 4-hydroxylated estrogen is of minor importance. In the present study the in vivo production of isomeric 2- and 3-monomethyl ethers of 2-hydroxyestrogens was measured in 12 healthy omnivorous male volunteers aged 51 ± 4 years. The sum of estrone and 17β-estradiol, 2-hydroxyestrogens (sum of 2-hydroxyestrone and 2-hydroxyestradiol), 4-hydroxyestrogens (sum of 4-hydroxyestrone and 4-hydroxyestradiol) and the sum of the isomeric monomethyl ethers of 2-hydroxyestrone and 2-hydroxyestradiol were measured in 24-h urinary samples. The determinations included hydrolysis of steroid conjugates, separation by chromatographic steps and final quantification by radioimmunoassay. The specificity of the antibodies enabled differentiation between the isomeric monomethyl ethers. The mean urinary excretion rates were 8.8 ± 2.9 μg/24 h for estrone plus estradiol, 5.2 ± 2.4 μg/24 h for the 2-hydroxyestrogens and 1.3 ± 0.5 μg/24 h for the 4-hydroxyestrogens. The 2- and 3-monomethyl ethers of the 2-hydroxyestrogens were found in all individuals, with excretion rates of 5.8 ± 2.6 μg/24 h for 2-methoxyestrogens and 3.6 ± 1.1 μg/24 h for 2-hydroxyestrogen-3-methyl ethers. The findings indicated that 2-hydroxyestradiol is metabolized in vivo by 2-O-methylation and, to a lesser extent, by 3-O-methylation. Markus Banger, Department of Psychiatry, University of Essen, Virchowstr. 174, 45147 Essen, Germany

Absolute Bioavailability, Pharmacokinetics, and Urinary Excretion of the Novel Antimigraine Agent Almotriptan in Healthy Male Volunteers

2002 ◽  
Vol 42 (12) ◽  
pp. 1303-1310 ◽  
Author(s):  
Josep M. Jansat ◽  
Joan Costa ◽  
Pau Salvà ◽  
Francisco J. Fernandez ◽  
Antonio Martinez-Tobed
Keyword(s):  
Urinary Excretion ◽  
Absolute Bioavailability ◽  
The Novel ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers

scholarly journals RENAL CLEARANCE AND URINARY EXCRETION OF MOXIFLOXACIN IN HEALTHY MALE VOLUNTEERS

2018 ◽  
Vol 2 (1) ◽  
pp. 19-22
Author(s):  
Asia Farid ◽  
Tanweer Khaliq ◽  
Hafiz Alam Sher ◽  
Atifa Mushtaq ◽  
Abdullah Abid
Keyword(s):  
Urinary Excretion ◽  
Renal Clearance ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers

Urinary Excretion of Acetylsalicylic Acid in Healthy Male Volunteers

2003 ◽  
Vol 6 (16) ◽  
pp. 1413-1415
Author(s):  
Bazghah Sadaf Siddiqui ◽  
Haq Nawaz Bhatti . ◽  
Ambreen Ijaz . ◽  
Saba Rasheed . ◽  
Bushra Saleem .
Keyword(s):  
Urinary Excretion ◽  
Acetylsalicylic Acid ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers

Glucocorticoid treatment is associated with dose-dependent insulin resistance in healthy male volunteers

2019 ◽  
Author(s):  
Riccardo Pofi ◽  
Ilaria Bonaventura ◽  
Nanthia Othonos ◽  
Thomas Marjot ◽  
Ahmed Moolla ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Healthy Male ◽  
Glucocorticoid Treatment ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Dose Dependent
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