In Vitro Development of Resistance to Human Immunodeficiency Virus Protease Inhibitor GW640385
2006 ◽
Vol 50
(3)
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pp. 1092-1095
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Keyword(s):
ABSTRACT Development of in vitro resistance to GW640385, a new human immunodeficiency virus type 1 protease inhibitor, was studied. Variants characterized included one with <4-fold resistance and amino acid substitutions Q58E/A71V (protease) and P452K (Gag) and one with >50-fold resistance and amino acid substitutions L10F/G16E/E21K/A28S/M46I/F53L/A71V (protease) and L449F/P453T (Gag). The A28S substitution substantially reduced replication capacity.
1997 ◽
Vol 41
(6)
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pp. 1313-1318
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2002 ◽
Vol 76
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pp. 3031-3037
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2003 ◽
Vol 77
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pp. 1512-1523
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2004 ◽
Vol 48
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pp. 2159-2165
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2003 ◽
Vol 47
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pp. 3123-3129
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Keyword(s):
2011 ◽
Vol 55
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pp. 5723-5731
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Vol 51
(9)
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pp. 3147-3154
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1993 ◽
Vol 37
(10)
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pp. 2231-2234
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2005 ◽
Vol 79
(19)
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pp. 12447-12454
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