scholarly journals Reduced Expression of Toll-Like Receptor 2 on Peripheral Monocytes in Patients with Chronic Hepatitis B

2006 ◽  
Vol 13 (8) ◽  
pp. 972-974 ◽  
Author(s):  
Stephen M. Riordan ◽  
Narelle Skinner ◽  
Jelica Kurtovic ◽  
Stephen Locarnini ◽  
Kumar Visvanathan
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Persistent Infection ◽  
Peripheral Blood Monocyte ◽  
Toll Like Receptor ◽  
Wild Type ◽  
Viral Inhibition ◽  
B Virus ◽  
Toll Like Receptor 2

ABSTRACT Persistent infection with hepatitis B virus (HBV) likely depends on viral inhibition of host defenses. We report that chronic hepatitis B e antigen-positive HBV infection is associated with a significant reduction in peripheral blood monocyte expression of Toll-like receptor 2, a key component of innate immunity, thereby providing a mechanism by which wild-type HBV may establish persistent infection.

scholarly journals Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein

Hepatology ◽  
2006 ◽  
Vol 45 (1) ◽  
pp. 102-110 ◽  
Author(s):  
Kumar Visvanathan ◽  
Narelle A. Skinner ◽  
Alex J.V. Thompson ◽  
Stephen M. Riordan ◽  
Vitini Sozzi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

Comparison of replication competence of wild-type and lamivudine-resistant hepatitis B virus isolates from a chronic hepatitis B patient

2018 ◽  
Vol 255 ◽  
pp. 165-170 ◽  
Author(s):  
Quan Zhang ◽  
Junhao Chen ◽  
Mingjie Pan ◽  
Jingli Liu ◽  
Tingting Liu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Wild Type ◽  
B Virus ◽  
Virus Isolates

scholarly journals The Possible Role of TLR2 in Chronic Hepatitis B Patients with Precore Mutation

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Malihe Moradzadeh ◽  
Sirous Tayebi ◽  
Hossein Poustchi ◽  
Kourosh Sayehmiri ◽  
Parisa Shahnazari ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Direct Sequencing ◽  
Innate Immune ◽  
Enzyme Linked Immunosorbent Assay ◽  
B Virus ◽  
Toll Like Receptor 2 ◽  
Negative Chronic Hepatitis

Recognition mechanisms of innate immune response help to improve immunotherapeutic strategies in HBeAg-negative chronic hepatitis B (CHB). Toll-like receptor 2 (TLR2) is an important component of innate immunity. In this study, the frequency of precore mutations of the hepatitis B virus (HBV) and serum TLR2 were evaluated in CHB patients. Fifty-one patients with chronic hepatitis B, negative for HBeAg and detectable HBV DNA, were examined for the presence of mutations in pre-core region of HBV genome by direct sequencing. Serum TLR2 was measured by enzyme-linked immunosorbent assay. Interactions of truncated HBeAg and TLR2 proteins were evaluated with molecular docking software. The G1896A pre-core mutation were detected in 29 (57%) which was significantly associated with higher concentration of serum TLR2 in comparison with patients without this mutation (4.8±2.9 versus 3.4±2.2 ng/mL,P=0.03). There was also a significant correlation between serum ALT and TLR-2 (r=0.46;P=0.01). Docking results illustrated residues within the N-terminus of truncated HBeAg and TLR2, which might facilitate the interaction of these proteins. These findings showed the dominance of G1896A pre-core mutation of HBV variants in this community which was correlated with serum TLR2. Moreover TLR2 is critical for induction of inflammatory cytokines and therefore ALT elevation.

scholarly journals Investigation of 1377C/T polymorphism of the Toll-like receptor 3 among patients with chronic hepatitis B

2016 ◽  
Vol 62 (7) ◽  
pp. 617-622 ◽  
Author(s):  
Emine Firat Goktas ◽  
Cemal Bulut ◽  
Mustafa Tugrul Goktas ◽  
Erdem Kamil Ozer ◽  
Ragip Ozgur Karaca ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hbv Dna ◽  
Control Group ◽  
Toll Like Receptor ◽  
Single Nucleotide ◽  
Significant Difference ◽  
B Virus ◽  
Receptor Family

The immunopathogenesis of chronic hepatitis B (CHB) has not been clarified yet. Toll-like receptors (TLR) are a receptor family that initiates immunity with exogenous–endogenous ligands and plays a role in the pathogenesis of infections. In this study, we aimed to investigate the frequency of TLR 3 1377C/T (rs3775290) polymorphism and its role in patients with CHB. We included 50 healthy individuals as control group and 73 active and 43 inactive hepatitis B patients. All DNA samples were isolated from blood samples. For the detection of TLR 3 1377C/T single-nucleotide polymorphism, restriction fragment length polymorphism was used. A statistically significant difference was determined in Hepatitis B virus (HBV) DNA levels of CHB patients with the CC, CT, and TT genotypes (p = 0.013). The highest levels of HBV DNA were detected in individuals with TT genotypes. Additionally, the frequency of CC genotype was higher in the active CHB patients compared with that of the inactive CHB patients (p = 0.044). No statistically significant difference in TLR 3 1377C/T polymorphism was detected between healthy controls and the hepatitis B patients (p = 0.342). In conclusion, HBV DNA level was higher in the individuals with TT genotype, and CC genotype was more frequent in the active CHB patients. These results suggest a possible association between CHB and TLR 3 gene (1377C/T) polymorphism.

The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection

2015 ◽  
Vol 63 (2) ◽  
pp. 320-328 ◽  
Author(s):  
Edward J. Gane ◽  
Young-Suk Lim ◽  
Stuart C. Gordon ◽  
Kumar Visvanathan ◽  
Eric Sicard ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis B Virus Infection ◽  
Toll Like Receptor ◽  
Chronic Hepatitis B Virus ◽  
B Virus
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