scholarly journals Mannan-Binding Lectin Enhances Susceptibility to Visceral Leishmaniasis

2001 ◽  
Vol 69 (8) ◽  
pp. 5212-5215 ◽  
Author(s):  
Isabel K. F. de Miranda Santos ◽  
Carlos H. N. Costa ◽  
Henrique Krieger ◽  
Mary F. Feitosa ◽  
David Zurakowski ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Visceral Leishmaniasis ◽  
Clinical Outcome ◽  
Tumor Necrosis ◽  
Leishmania Chagasi ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Mannan Binding Lectin ◽  
Binding Lectin ◽  
Necrosis Factor

ABSTRACT Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites. Our findings indicate that MBL can modulate the clinical outcome of infection with L. chagasi and the function of infected macrophages.

Prospective, Randomized Study Comparing Two Different Minimized versus Conventional Cardiopulmonary Bypass Systems

2010 ◽  
Vol 5 (4) ◽  
pp. 270-277 ◽  
Author(s):  
Jeannette Schoenebeck ◽  
Munif Haddad ◽  
Karl Wegscheider ◽  
Elrina Joubert-Huebner ◽  
Hermann Reichenspurner ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Tumor Necrosis Factor ◽  
Clinical Outcome ◽  
Tumor Necrosis ◽  
Troponin T ◽  
Randomized Study ◽  
Necrosis Factor Alpha ◽  
Group A ◽  
Factor Alpha ◽  
Necrosis Factor

Objective Conventional cardiopulmonary bypass (CCPB) is a major trigger of inflammatory response. We aimed to assess the impact of two different minimized cardiopulmonary bypass systems (mini-CPB) with and without Bioline-coating compared with CCPB regarding organ function, inflammatory response, and early clinical outcome. Methods In a prospective, randomized study, 120 patients underwent elective coronary artery bypass grafting and were randomized into three groups: mini-CPB using a Bioline-coated (group A, n = 40) or an uncoated (group B, n = 40) circuit, or CCPB (group C, n = 40). Cytokines (interleukin-6, interleukin-8, and tumor necrosis factor-alpha), myocardial markers (creatine kinase [CK], CK-MB, and troponin-T), hematocrit, and platelet counts were measured up to 48 hours postoperatively. Early clinical outcome was assessed at 3 months postoperatively. Results Demographics, number of distal anastomoses, ventilation time, blood loss, intensive care unit, and hospital stay were comparable (P = not significant). Extracorporeal circulation and cross-clamp time were significantly longer in group A and B versus C (P < 0.005). No significant differences could be found in the release of interleukin-6, interleukin-8, and tumor necrosis factor-alpha among groups. Myocardial markers were significantly reduced in group A and B versus group C (P < 0.001). Hematocrit and platelet counts did not differ among the groups. No differences could be found in early clinical outcome up to 3 months. Conclusions This study showed significant better myocardial preservation with lower CK-MB and troponin-T levels in both mini-CPB groups. No significant differences could be found in terms of inflammation, hematologic effects, and early clinical outcome.

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