Nipah Virus Edits Its P Gene at High Frequency To Express the V and W Proteins
Keyword(s):
P Gene
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ABSTRACT Nipah virus (NiV) is predicted to encode four proteins from its P gene (P, V, W, and C) via mRNA editing and an alternate open reading frame. By use of specific antibodies, the expression of the V, W, and C proteins in NiV-infected cells has now been confirmed. Analysis of the P-gene transcripts shows a ratio of P:V:W mRNA of 1:1:1, but this differs over time, with greater proportions of V and W transcripts observed as the infection progresses. Eighty-two percent of transcripts are edited, with up to 11 G insertions observed. This exceptionally high editing frequency ensures expression of the V and W proteins.
2000 ◽
Vol 74
(8)
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pp. 3586-3597
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1998 ◽
Vol 72
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pp. 2265-2271
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Keyword(s):
1999 ◽
Vol 73
(3)
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pp. 2027-2037
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2006 ◽
Vol 80
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pp. 3541-3548
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