The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.

Double Stranded Rna ◽

Phosphorylation of Plant Eukaryotic Initiation Factor-2 by the Plant-encoded Double-stranded RNA-dependent Protein Kinase, pPKR, and Inhibition of Protein Synthesisin Vitro

Journal of Biological Chemistry ◽

10.1074/jbc.271.8.4539 ◽

1996 ◽

Vol 271 (8) ◽

pp. 4539-4544 ◽

Cited By ~ 41

Author(s):

Jeffrey O. Langland ◽

Lisa A. Langland ◽

Karen S. Browning ◽

Don A. Roth

Keyword(s):

Protein Kinase ◽

Initiation Factor ◽

Dependent Protein Kinase ◽

Double Stranded Rna ◽

Initiation Factor 2 ◽

Dependent Protein

Nuclear Factor 90 Is a Substrate and Regulator of the Eukaryotic Initiation Factor 2 Kinase Double-stranded RNA-activated Protein Kinase

Journal of Biological Chemistry ◽

10.1074/jbc.m104408200 ◽

2001 ◽

Vol 276 (35) ◽

pp. 32522-32530 ◽

Cited By ~ 66

Author(s):

Lisa M. Parker ◽

Ivo Fierro-Monti ◽

Michael B. Mathews

Keyword(s):

Protein Kinase ◽

Initiation Factor ◽

Nuclear Factor ◽

Double Stranded Rna ◽

Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)31463-7 ◽

1993 ◽

Vol 268 (17) ◽

pp. 12837-12842

Author(s):

K. Carroll ◽

O. Elroy-Stein ◽

B. Moss ◽

R. Jagus

Keyword(s):

Protein Kinase ◽

Vaccinia Virus ◽

Gene Product ◽

Recombinant Vaccinia Virus ◽

Specific Protein ◽

Initiation Factor ◽

Recombinant Vaccinia ◽

Double Stranded Rna ◽

Initiation Factor 2 ◽

Specific Protein Kinase

Homologous Regions of the alpha Subunit of Eukaryotic Translational Initiation Factor 2 (eIF2alpha) and the Vaccinia Virus K3L Gene Product Interact with the Same Domain within the dsRNA-Activated Protein Kinase (PKR)

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1997.00085.x ◽

1997 ◽

Vol 250 (1) ◽

pp. 85-91 ◽

Cited By ~ 40

Author(s):

Tyson V. Sharp ◽

J. Eric Witzel ◽

Rosemary Jagus

Keyword(s):

Protein Kinase ◽

Vaccinia Virus ◽

Gene Product ◽

Initiation Factor ◽

Alpha Subunit ◽

Translational Initiation ◽

Initiation Factor 2 ◽

Translational Initiation Factor

Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase.

10.1073/pnas.88.17.7729 ◽

1991 ◽

Vol 88 (17) ◽

pp. 7729-7733 ◽

Cited By ~ 125

Author(s):

J. J. Chen ◽

M. S. Throop ◽

L. Gehrke ◽

I. Kuo ◽

J. K. Pal ◽

...

Keyword(s):

Protein Kinase ◽

Initiation Factor ◽

Double Stranded Rna ◽

Initiation Factor 2 ◽

Rabbit Reticulocytes

In situ phosphorylation of the subunit of eukaryotic initiation factor 2 in reticulocyte lysates inhibited by heme deficiency, double-stranded RNA, oxidized glutathione, or the heme-regulated protein kinase

10.1073/pnas.76.5.2118 ◽

1979 ◽

Vol 76 (5) ◽

pp. 2118-2122 ◽

Cited By ~ 46

Author(s):

V. Ernst ◽

D. H. Levin ◽

I. M. London

Keyword(s):

Protein Kinase ◽

Initiation Factor ◽

Oxidized Glutathione ◽

Double Stranded Rna ◽

Initiation Factor 2 ◽

Reticulocyte Lysates

Regulation of protein synthesis: Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2

10.1073/pnas.75.3.1121 ◽

1978 ◽

Vol 75 (3) ◽

pp. 1121-1125 ◽

Cited By ~ 129

Author(s):

D. Levin ◽

I. M. London

Keyword(s):

Protein Synthesis ◽

Protein Kinase ◽

Initiation Factor ◽

Double Stranded Rna ◽

Okadaic Acid Induces Apoptosis through Double-Stranded RNA-Dependent Protein Kinase/Eukaryotic Initiation Factor-2 Pathway in Human Osteoblastic MG63 Cells

The Journal of Biochemistry ◽

10.1093/jb/mvh144 ◽

2004 ◽

Vol 136 (4) ◽

pp. 433-438 ◽

Cited By ~ 24

Author(s):

H. Morimoto

Keyword(s):

Protein Kinase ◽

Okadaic Acid ◽

Initiation Factor ◽

Dependent Protein Kinase ◽

Double Stranded Rna ◽

Mg63 Cells ◽

Initiation Factor 2 ◽

Dependent Protein

Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression ◽

10.1016/0167-4781(94)90229-1 ◽

1994 ◽

Vol 1219 (3) ◽

pp. 693-696 ◽

Cited By ~ 13

Author(s):

Harry Mellor ◽

Kevin M. Flowers ◽

Scot R. Kimball ◽

Leonard S. Jefferson

Keyword(s):

Initiation Factor ◽

Double Stranded Rna ◽

Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.

10.1073/pnas.86.8.2784 ◽

1989 ◽

Vol 86 (8) ◽

pp. 2784-2788 ◽

Cited By ~ 102

Author(s):

A. M. Cigan ◽

E. K. Pabich ◽

L. Feng ◽

T. F. Donahue

Keyword(s):

Translation Initiation ◽

Initiation Factor ◽

Alpha Subunit ◽

Sequence Identity ◽