Patient-Specific Cytotoxic T-Lymphocyte Cross-Recognition of Naturally Occurring Variants of a Human Immunodeficiency Virus Type 1 (HIV-1) p24gagEpitope by HIV-1-Infected Children
2001 ◽
Vol 75
(10)
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pp. 4941-4946
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Keyword(s):
ABSTRACT We tested seven human immunodeficiency virus-infected children for their cytotoxic T-lymphocyte (CTL) activities towards the p24 gag QASQEVKNW epitope and its nine variant sequences. Our data confirm that most, but not all, CTL responses are broadly cross-specific. For the first time, we show the high interpatient variability in cross-recognition of mutant CTL epitopes. These interindividual variations in the CTL response to the same epitope should be taken into account in the design and the evaluation of vaccines.
1996 ◽
Vol 174
(4)
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pp. 734-738
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2001 ◽
Vol 75
(9)
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pp. 4430-4434
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2005 ◽
Vol 79
(18)
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pp. 12100-12105
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1998 ◽
Vol 72
(4)
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pp. 3472-3474
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1999 ◽
Vol 73
(8)
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pp. 6721-6728
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1999 ◽
Vol 73
(8)
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pp. 6715-6720
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2004 ◽
Vol 78
(16)
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pp. 8927-8930
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2001 ◽
Vol 75
(6)
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pp. 2706-2709
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