Heterochronies in the formation of the nervous and digestive systems in early postlarval development of opisthobranch mollusks: Organization of major organ systems of the arctic dorid Cadlina laevis

2015 ◽  
Vol 42 (3) ◽  
pp. 186-195 ◽  
Author(s):  
O. V. Zaitseva ◽  
A. N. Shumeev ◽  
T. A. Korshunova ◽  
A. V. Martynov
Keyword(s):  
The Arctic ◽  
Organ Systems ◽  
Major Organ

FEATURES OF FORMATION OF THE MAIN SYSTEMS AND ORGANS IN EARLY LARVAE OF MULLETS (LIZA AURATA, RISSO, 1810)

2017 ◽  
pp. 98-106
Author(s):  
Dariya Aleksandrovna Gavrilova ◽  
Maria Pavlovna Grushko
Keyword(s):  
Nervous System ◽  
Sample Selection ◽  
Early Ontogeny ◽  
Basal Cells ◽  
The Caspian Sea ◽  
Liza Aurata ◽  
Morphological Organization ◽  
Organ Systems ◽  
Major Organ ◽  
Well Differentiated

The aim of this work was to study peculiarities of mullet morphological organization during early ontogeny. Sample selection was made on board Caspian research and development Institute of Fisheries’ research vessel in period from June to September, 2015 in Russian waters of the Caspian Sea. Larvae aged 10 days could be characterized by heterochrony in the development of major organ systems. Nervous system and sense organs were well developed. The eyeball had all membranes well-differentiated, in the retina all the layers were formed. The olfactory fossae had cells of 3 types: olfactory receptor cells, supporting cells and basal cells. There was observed intensive formation of respiratory, cardiovascular, excretory and digestive systems. The early development of the nervous system and sensory organs of the larvae indicated adaptation of mullet to active life.

scholarly journals SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney

2021 ◽  
Author(s):  
Magen E. Francis ◽  
Una Goncin ◽  
Andrea Kroeker ◽  
Cynthia Swan ◽  
Robyn Ralph ◽  
...  
Keyword(s):  
Type I Interferon ◽  
Clinical Symptoms ◽  
Type I Interferons ◽  
Host Responses ◽  
Type I ◽  
Hamster Model ◽  
Organ Systems ◽  
Major Organ ◽  
Kidney Liver ◽  
Multiorgan Disease

AbstractCOVID-19 (coronavirus disease 2019) caused SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is a disease affecting several organ systems. A model that captures all clinical symptoms of COVID-19 as well as long-haulers disease is needed. We investigated the host responses associated with infection in several major organ systems including the respiratory tract, the heart, and the kidneys after SARS-CoV-2 infection in Syrian hamsters. We found significant increases in inflammatory cytokines (IL-6, IL-1beta, and TNF) and type II interferons whereas type I interferons were inhibited. Examination of extrapulmonary tissue indicated inflammation in the kidney, liver, and heart which also lacked type I interferon upregulation. Histologically, the heart had evidence of mycarditis and microthrombi while the kidney had tubular inflammation. These results give insight into the multiorgan disease experienced by people with COVID-19 and possibly the prolonged disease in people with post-acute sequelae of SARS-CoV-2 (PASC).

Common Adverse Effects of Antibacterial Agents on Major Organ Systems

1980 ◽  
Vol 60 (1) ◽  
pp. 65-81 ◽  
Author(s):  
Stephen B. Calderwood ◽  
Robert C. Moellering
Keyword(s):  
Adverse Effects ◽  
Antibacterial Agents ◽  
Organ Systems ◽  
Major Organ

Cushing’s Disease

2017 ◽  
Author(s):  
Doris M. Hardacker
Keyword(s):  
Perioperative Management ◽  
Preoperative Assessment ◽  
Definitive Treatment ◽  
Perioperative Morbidity ◽  
Anesthetic Drugs ◽  
Organ Systems ◽  
Wide Range ◽  
Major Organ ◽  
Acth Secreting ◽  
Potential Interactions

Cushing’s syndrome is caused by adrenocorticotropic hormone (ACTH)-secreting or cortisol-secreting tumors. In most cases, the hypercortisolism is caused by an ACTH-secreting tumor of the pituitary. An excess of circulating cortisol adversely affects all major organ systems, including the cardiovascular system and therefore produces a wide range of clinical features. Perioperative morbidity and mortality will largely be determined by the magnitude of cardiac dysfunction encountered. Successful perioperative management depends on a thorough preoperative assessment of affected organs, comprehensive intraoperative monitoring, and an understanding of potential interactions with anesthetic drugs. Surgical reselection is most often the definitive treatment for this syndrome, however there are pharmacologic interventions that can be undertaken when necessary.

Nitrite Oxidase Activities of Cytochrome P450 and Mitochondria

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 5310-5310
Author(s):  
Erin Curtis ◽  
Lewis L Hsu ◽  
Yuen Yi Hon ◽  
Lisa Geary ◽  
Audrey C Noguchi ◽  
...  
Keyword(s):  
Conflicts Of Interest ◽  
Intraperitoneal Administration ◽  
Biological Responses ◽  
Iron Nitrosyl ◽  
Organ Systems ◽  
Major Organ ◽  
Nitrite Uptake ◽  
Rats And Mice

Abstract Abstract 5310 Once dismissed as an inert byproduct of nitric oxide (NO) auto-oxidation, nitrite (NO2−) is now accepted as an endocrine reserve of NO that elicits a number of fundamental biological responses in all major organ systems. While it is known that tissue nitrite is derived from both oxidation of NO and from dietary nitrite and nitrate, much less is known about how nitrite is metabolized by tissue or about the factors that influence this metabolism. Here we investigate the rates and mechanisms by which nitrite is metabolized by tissue over a range of oxygen tensions in rats and mice. We show that the rate of nitrite metabolism differs in heart, liver, lung and brain tissue. Further, oxygen regulates the rate and products of nitrite metabolism in each of these tissues. In hypoxic tissue, nitrite is predominantly reduced to NO, with significant formation of iron-nitrosyl heme proteins and S-nitrosothiols. Interestingly, this hypoxic nitrite metabolism is mediated by different sets of nitrite reductase enzymes in each tissue. In contrast, tissue consumption of nitrite is more rapid in normoxia and the major end product is nitrate. While cytochrome P450s and myoglobin contributed in the liver and heart respectively, mitochondrial cytochrome c oxidase played a significant role in this normoxic nitrite oxidation, which could be completely inhibited by cyanide in all tissues. We used cyanide-based nitrite preservation solution to measure the pharmacokinetics of oral and intraperitoneally administered nitrite in vivo. Using this methodology, we measured basal levels of nitrite in the major tissues and confirm that the heart contains the greatest concentration of nitrite, followed by the liver and finally the lung. We demonstrate that intraperitoneal administration of nitrite to mice increases nitrite levels most significantly in the liver and heart, where nitrite uptake is rapid (5–10 min) and steadily decreases thereafter, such that levels are back to baseline by 30 min. Little to no increase was observed in the lung. In these studies, changes in nitrate were difficult to detect due to the high levels of basal nitrate present in vivo and low concentration of nitrite administered. However, the rapid metabolism of nitrite in the tissue suggests that oxidation is at least partially responsible. In contrast to intraperitoneal nitrite, oral nitrite increased nitrite levels in all organs of mice, an effect which peaked in all organs except liver at 3 days. Collectively, these data provide insight into the fate of nitrite in tissue, the enzymes involved in hypoxic and normoxic nitrite metabolism and the role of oxygen in regulating these processes. Disclosures: No relevant conflicts of interest to declare.

EXORISTOBIA PHILIPPINENSIS, A HYMENOPTERAN ENDOPARASITE OF PUPARIA OF SYNANTHROPIC FLIES (HYMENOPTERA: ENCYRTIDAE: I. HISTOLOGICAL STUDIES OF ITS LIFE CYCLE

1974 ◽  
Vol 106 (2) ◽  
pp. 201-208 ◽  
Author(s):  
Beng-Chuan Ho ◽  
Sau-Pheng Kan ◽  
Kai-Lok Chan ◽  
Agnes Sih ◽  
E. J. LeRoux
Keyword(s):  
Life Cycle ◽  
Histological Studies ◽  
Laboratory Conditions ◽  
Organ Systems ◽  
Major Organ

AbstractThs paper describes and illustrates, with photomicrographs, the gross histological development of stages of the endoparasitoid Exoristobia philippinensis Ashmead in the puparia of three synanthropic flies under laboratory conditions. The major organ systems, especially nervous, digestive, reproductive and respiratory are traced.

scholarly journals ACECLOFENAC-INDUCED STEVENS-JOHNSON SYNDROME AFTER ONE SINGLE DOSE: A MAIDEN CASE REPORT

2018 ◽  
Vol 11 (9) ◽  
pp. 1 ◽  
Author(s):  
Saurabh Agarwal ◽  
Balaji O ◽  
Navin Patil
Keyword(s):  
Case Reports ◽  
Tertiary Care ◽  
Stevens Johnson Syndrome ◽  
Care Hospital ◽  
Skin Reactions ◽  
Johnson Syndrome ◽  
Organ Systems ◽  
Major Organ ◽  
Threatening Condition ◽  
Life Threatening

Drugs are known to cause various adverse drug reactions involving major organ systems. Skin-related adverse reactions are very common and range from a simple rash to life-threatening condition like Stevens-Johnson syndrome. Various drugs are known to cause skin reactions which include antiepileptics, analgesics, antibiotics, and proton-pump inhibitors. Nonsteroidal anti-inflammatory drugs causing life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis are very rare and only few case reports are published. Hence, we report a case of Aceclofenac-induced Stevens-Johnson syndrome after single time administration in a tertiary care hospital in India.

Sign in / Sign up

Export Citation Format

Share Document