Direct synthesis of ethers from aldehydes and ketones. One-pot reductive etherification of benzaldehydes, alkyl aryl ketones, and benzophenones

2016 ◽  
Vol 52 (4) ◽  
pp. 503-512 ◽  
Author(s):  
S. S. Mochalov ◽  
A. N. Fedotov ◽  
E. V. Trofimova ◽  
N. S. Zefirov
Keyword(s):  
Direct Synthesis ◽  
One Pot ◽  
Alkyl Aryl ◽  
Aldehydes And Ketones ◽  
Aryl Ketones

One-Pot Access to 4-Aryl-2-arylacetoxynaphthalenes via Benz­annulation of Oxygenated Arylacetic Acids and Alkyl Aryl Ketones

Synthesis ◽  
2020 ◽  
Vol 52 (07) ◽  
pp. 1035-1046 ◽  
Author(s):  
Meng-Yang Chang ◽  
Shin-Mei Chen ◽  
Yu-Ting Hsiao
Keyword(s):  
Bond Formation ◽  
Trifluoroacetic Anhydride ◽  
Ring Closure ◽  
One Pot ◽  
Alkyl Aryl ◽  
Highly Effective ◽  
Aryl Ketones ◽  
Arylacetic Acids ◽  
Plausible Mechanism

Trifluoroacetic anhydride mediated one-pot intermolecular formal (4+2) benzannulation of oxygenated arylacetic acids with alkyl aryl ketones provides 4-aryl-2-arylacetoxynaphthalenes in moderate to good yields in the presence of H3PO4 in an open-vessel in a straightforward procedure. A plausible mechanism is proposed and discussed. This protocol provides a highly effective ring-closure via two carbon–carbon (C–C) and one carbon–oxygen (C–O) bond-formation events.

Palladium catalyzed decarboxylative acylation of arylboronic acid with ethyl cyanoacetate as a new acylating agent: synthesis of alkyl aryl ketones

2015 ◽  
Vol 39 (11) ◽  
pp. 8763-8770 ◽  
Author(s):  
Md Yousuf ◽  
Tuluma Das ◽  
Susanta Adhikari
Keyword(s):  
Ethyl Cyanoacetate ◽  
Acylating Agent ◽  
Arylboronic Acid ◽  
One Pot ◽  
Alkyl Aryl ◽  
One Pot Synthesis ◽  
Aryl Ketones ◽  
Palladium Catalyzed

The versatile, one-pot synthesis of a series of alkyl aryl ketones is described using ethyl cyanoacetate as a new acylating agent.

scholarly journals A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry

2014 ◽  
Vol 4 (2) ◽  
pp. 171-179 ◽  
Author(s):  
William Shearouse ◽  
Maxwell Shumba ◽  
James Mack
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
Alkyl Aryl ◽  
Gewald Reaction ◽  
Aryl Ketones ◽  
One Step

One-pot synthesis of cyclohexylamine and N-aryl pyrroles via hydrogenation of nitroarenes over the Pd0.5Ru0.5-PVP catalyst

2021 ◽  
Author(s):  
Chandan Chaudhari ◽  
Katsutoshi Sato ◽  
Yasuyuki Ikeda ◽  
Kenji Terada ◽  
Naoya Abe ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
One Pot ◽  
One Pot Synthesis

The direct synthesis of cyclohexylamine via hydrogenation of nitrobenzene over monometallic (Pd, Ru or Rh) and bimetallic (PdxRu1−x) catalysts was studied.

scholarly journals 2-Aryl-6-Polyfluoroalkyl-4-Pyrones as Promising RF-Building-Blocks: Synthesis and Application for Construction of Fluorinated Azaheterocycles

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4415
Author(s):  
Sergey A. Usachev ◽  
Diana I. Nigamatova ◽  
Daria K. Mysik ◽  
Nikita A. Naumov ◽  
Dmitrii L. Obydennov ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
Building Blocks ◽  
Oxidative Cyclization ◽  
One Pot ◽  
Synthetic Application ◽  
General Method

A convenient and general method for the direct synthesis of 2-aryl-6-(trifluoromethyl)-4-pyrones and 2-aryl-5-bromo-6-(trifluoromethyl)-4-pyrones has been developed on the basis of one-pot oxidative cyclization of (E)-6-aryl-1,1,1-trifluorohex-5-ene-2,4-diones via a bromination/dehydrobromination approach. This strategy was also applied for the preparation of 2-phenyl-6-polyfluoroalkyl-4-pyrones and their 5-bromo derivatives. Conditions of chemoselective enediones bromination were found and the key intermediates of the cyclization of bromo-derivatives to 4-pyrones were characterized. Synthetic application of the prepared 4-pyrones has been demonstrated for the construction of biologically important CF3-bearing azaheterocycles, such as pyrazoles, pyridones, and triazoles.

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