Comparative Study of Plant Physiological Responses to Long-Term and Short-Term Daily Exposures to Low Temperature in the Presence of Protein-Synthesis Inhibitors

2020 ◽  
Vol 10 (1) ◽  
pp. 71-80
Author(s):  
E. G. Sherudilo ◽  
T. G. Shibaeva ◽  
E. N. Ikkonen ◽  
A. F. Titov
Keyword(s):  
Protein Synthesis ◽  
Low Temperature ◽  
Comparative Study ◽  
Physiological Responses ◽  
Protein Synthesis Inhibitors ◽  
Short Term

Drug inhibition of memory formation in chickens II. Short-term memory

1971 ◽  
Vol 178 (1053) ◽  
pp. 455-464 ◽  
Keyword(s):  
Protein Synthesis ◽  
Sodium Pump ◽  
Short Term Memory ◽  
Memory Loss ◽  
Protein Synthesis Inhibitor ◽  
Protein Synthesis Inhibitors ◽  
Short Term ◽  
Synthesis Inhibitor ◽  
Term Memory

1. Memory in day-old-chickens during the first few hours after learning can be made to decline by the prior intracranial injection of two classes of drugs. 2. Sodium pump inhibitors in increasing doses cause increasingly rapid loss of memory. 3. Protein synthesis inhibitors in increasing doses attain a maximum potency in causing memory decline and the rate may not be further accelerated by higher doses. 4. Adding a sodium pump inhibitor to the inhibition of protein synthesis increases memory loss. 5. Adding a protein synthesis inhibitor to a sodium pump inhibitor causes no further loss. 6. Therefore within a few minutes of learning a short-term memory of limited time span but independent of protein synthesis becomes supplemented and eventually replaced by a long-term storage requiring protein synthesis. The amount of long-term store is set by the amount of short-term memory. 7. The short-term store could be directly dependent on post-activation enhancement of Na + extrusion from neurons. Some physiological mechanisms by which this could be achieved and how this might activate protein synthesis are discussed.

scholarly journals COMPARATIVE ANALYSIS OF LOW TEMPERATURE RESISTANCE FOR NANOCARBON AND OTHER BITUMENS

2020 ◽  
Vol 5 (443) ◽  
pp. 89-96
Author(s):  
Zhurinov M.Zh., ◽  
◽  
Teltayev B.B., ◽  
Kalybay A.A., ◽  
Rossi C.O., ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Low Temperature ◽  
Polyphosphoric Acid ◽  
Crumb Rubber ◽  
Petrochemical Plant ◽  
Short Term ◽  
Temperature Resistance ◽  
Coal Rock ◽  
Low Temperature Resistance

A comparative analysis of the low temperature resistance for a nanocarbon bitumen and other 30 neat and modified bitumens has been performed in the work. The stiffness at the temperatures of -24°С, -30°С and -36°С under technical system Superpave has been accepted as an indicator of low temperature resistance of the bitumens. The stiffness of the bitumens has been determined on a bending beam rheometer (standard ASTM D 6648-08). Before testing the bitumens have been subjected to the double artificial aging: short-term aging – under standard AASHTO Т 240-13 and long-term aging – under standard ASTM D 6521-08. The nanocarbon bitumen has been prepared in the laboratory of the Kazakhstan Highway Research Institute (KazdorNII) with the use of a road bitumen of the grade BND 70/100 produced by the Pavlodar petrochemical plant (PNHZ) and a nanocarbon powder (2% by weight) manufactured from a coal rock of the deposit “Saryadyr” “Corporation “ON-Olzha” LLP, Akmola region, Kazakhstan). The nanocarbon powder (150-200 nm) has been manufactured by three-stage size reduction of the coal rock: I – a mechanical dispergator (up to 2-3 mm), II – an aerodynamic mill (up to 20 mcm), III – a reactor with a rotating electromagnetic field. The neat bitumens of the grades BND 50/70, BND 70/100, BND 100/130 have been produced by the plants of Kazakhstan and Russia; they satisfy the requirements of the standard ST RK 1373-2013. The modified bitumens have been prepared in the laboratory of KazdorNII with the use of the neat bitumens, 7 types of the polymers, crumb rubber and polyphosphoric acid and they satisfy the requirements of the standard ST RK 2534-2014. It has been determined that the nanocarbon bitumen is one of the most resistant at the low temperatures: -24°С, -30°С and -36°С.

Long-term regulation of hexose uptake by isoproterenol in cultured 3T3 adipocytes

1985 ◽  
Vol 248 (6) ◽  
pp. E706-E711 ◽  
Author(s):  
J. P. van Putten ◽  
H. M. Krans
Keyword(s):  
Protein Synthesis ◽  
Prolonged Exposure ◽  
Term Effect ◽  
Long Term Effects ◽  
Fat Cell ◽  
Short Term ◽  
Long Term Effect ◽  
Short Term Exposure ◽  
Hexose Uptake

Catecholamines are known to have short-term regulatory effects on fat cell hexose uptake. We examined the long-term effects of catecholamines on the insulin-sensitive 2-deoxyglucose (dGlc) uptake in cultured 3T3-L1 adipocytes. Prolonged exposure (48 h) to isoproterenol (beta-adrenergic agonist) stimulated the basal dGlc uptake up to 90%. The effect was specific, time, concentration, and protein synthesis dependent and reversible. The effect of insulin was unaltered and superimposed on the increase in basal dGlc uptake. The long-term effect of isoproterenol was mimicked by epinephrine, dibutyryl cAMP (DBcAMP), and 1-methyl-3-isobutylxanthine (IBMX). By contrast, short-term exposure to isoproterenol (and epinephrine) induced a protein synthesis-independent increase in basal dGlc uptake (30%) not accompanied by an increase in insulin responsiveness. Moreover, on short-term basis, DBcAMP and IBMX suppressed both the basal and insulin-stimulated uptake up to 50%. Determination of the intracellular nonphosphorylated dGlc during the uptake and of the hexokinase activity revealed that the long-term effect of isoproterenol was most likely due to alterations low in dGlc transport. In conclusion, long-term regulators of hexose uptake are in cultured 3T3-L1 adipocytes, isoproterenol, and other cAMP stimulators. The long-term effect is independent from the short-term regulatory effect of the agents and from the effect of insulin.

scholarly journals Spatial-Memory Formation After Spaced Learning Involves ERKs1/2 Activation Through a Behavioral-Tagging Process

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ramiro Tintorelli ◽  
Pablo Budriesi ◽  
Maria Eugenia Villar ◽  
Paul Marchal ◽  
Pamela Lopes da Cunha ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Prior Training ◽  
Short Term ◽  
Promoting Effect ◽  
Cellular Processes ◽  
Spaced Learning ◽  
Inter Trial Interval ◽  
Established Fact ◽  
Massed Learning

AbstractThe superiority of spaced over massed learning is an established fact in the formation of long-term memories (LTM). Here we addressed the cellular processes and the temporal demands of this phenomenon using a weak spatial object recognition (wSOR) training, which induces short-term memories (STM) but not LTM. We observed SOR-LTM promotion when two identical wSOR training sessions were spaced by an inter-trial interval (ITI) ranging from 15 min to 7 h, consistently with spaced training. The promoting effect was dependent on neural activity, protein synthesis and ERKs1/2 activity in the hippocampus. Based on the “behavioral tagging” hypothesis, which postulates that learning induces a neural tag that requires proteins to induce LTM formation, we propose that retraining will mainly retag the sites initially labeled by the prior training. Thus, when weak, consecutive training sessions are experienced within an appropriate spacing, the intracellular mechanisms triggered by each session would add, thereby reaching the threshold for protein synthesis required for memory consolidation. Our results suggest in addition that ERKs1/2 kinases play a dual role in SOR-LTM formation after spaced learning, both inducing protein synthesis and setting the SOR learning-tag. Overall, our findings bring new light to the mechanisms underlying the promoting effect of spaced trials on LTM formation.

Effect of Extended Aging on Asphalt Materials Containing Re-Refined Engine Oil Bottoms

2017 ◽  
Vol 2632 (1) ◽  
pp. 60-69 ◽  
Author(s):  
David J. Mensching ◽  
Adrian Andriescu ◽  
Christopher DeCarlo ◽  
Xinjun Li ◽  
Jack S. Youtcheff
Keyword(s):  
Low Temperature ◽  
Fatigue Testing ◽  
Asphalt Mixture ◽  
Field Performance ◽  
Cyclic Fatigue ◽  
Engine Oil ◽  
Short Term ◽  
Bending Beam Rheometer ◽  
The Difference

The use of re-refined engine oil bottoms (REOBs) in asphalt pavements is a topic of much debate because the aging susceptibility and quantity of the additive in the binder may affect field performance. In this study, four mixtures with varying REOB contents (up to 15%) were long-term oven aged by using a high-temperature, short-duration method (135°C, 24 h) and compared with existing data on mixtures aged with more conventional short-term and long-term oven-aging procedures. The recovered binders underwent Superpave® grading, double-edge notched tension, and extended bending beam rheometer testing, and the binders were subjected to dynamic modulus, cyclic fatigue testing in the asphalt mixture performance tester, and thermal stress restrained specimen testing. Results showed a general insensitivity when short-term oven-aged (135°C, 4 h) materials were compared with long-term oven-aged (85°C, 5 days) materials, whereas the aging process at 135°C over 24 h resulted in substantial changes to the stiffness and relaxation properties across high-, intermediate-, and low-temperature modes. The difference between the stiffness-based and slope-based low-temperature performance grades appears to be an indicator for REOB modification, with the test for physical hardening of the binder being more sensitive than standard bending beam rheometer testing. The details in this paper provide information for the asphalt pavement community to consider as specifications. Standard practices are developed to address REOB modification.

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