SAT0334 Three Trajectories of Activity Limitations in Early Symptomatic Knee Osteoarthritis: a 5-Year Follow-Up Study

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A696.2-A696 ◽  
Author(s):  
J. F. Holla ◽  
M. van der Leeden ◽  
M. W. Heymans ◽  
L. D. Roorda ◽  
S. M. Bierma-Zeinstra ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Activity Limitations ◽  
Follow Up Study ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

Three trajectories of activity limitations in early symptomatic knee osteoarthritis: a 5-year follow-up study

2013 ◽  
Vol 73 (7) ◽  
pp. 1369-1375 ◽  
Author(s):  
Jasmijn F M Holla ◽  
Marike van der Leeden ◽  
Martijn W Heymans ◽  
Leo D Roorda ◽  
Sita M A Bierma-Zeinstra ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Activity Limitations ◽  
Follow Up Study ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

scholarly journals Three trajectories of activity limitations in early symptomatic knee osteoarthritis: a 5-year follow-up study

2013 ◽  
Vol 21 ◽  
pp. S136
Author(s):  
J. Holla ◽  
M. van der Leeden ◽  
M. Heymans ◽  
L. Roorda ◽  
S. Bierma-Zeinstra ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Activity Limitations ◽  
Follow Up Study ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

scholarly journals CHECK (Cohort Hip and Cohort Knee): similarities and differences with the Osteoarthritis Initiative

2008 ◽  
Vol 68 (9) ◽  
pp. 1413-1419 ◽  
Author(s):  
J Wesseling ◽  
J Dekker ◽  
W B van den Berg ◽  
S M A Bierma-Zeinstra ◽  
M Boers ◽  
...  
Keyword(s):  
Health Status ◽  
Knee Osteoarthritis ◽  
Functional Disability ◽  
Short Form ◽  
Follow Up Study ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee ◽  
Study Population ◽  
Osteoarthritis Initiative

Objective:To describe the osteoarthritis study population of CHECK (Cohort Hip and Cohort Knee) in comparison with relevant selections of the study population of the Osteoarthritis Initiative (OAI) based on clinical status and radiographic parameters.Methods:In The Netherlands a prospective 10-year follow-up study was initiated by the Dutch Arthritis Association on participants with early osteoarthritis-related complaints of hip and/or knee: CHECK. In parallel in the USA an observational 4-year follow-up study, the OAI, was started by the National Institutes of Health, on patients with or at risk of symptomatic knee osteoarthritis. For comparison with CHECK, the entire cohort and a subgroup of individuals excluding those with exclusively hip pain were compared with relevant subpopulations of the OAI.Results:At baseline, CHECK included 1002 participants with in general similar characteristics as described for the OAI. However, significantly fewer individuals in CHECK had radiographic knee osteoarthritis at baseline when compared with the OAI (p<0.001). In contrast, at baseline, the CHECK cohort reported higher scores on pain, stiffness and functional disability (Western Ontario and McMaster osteoarthritis index) when compared with the OAI (all p<0.001). These differences were supported by physical health status in contrast to mental health (Short Form 36/12) was at baseline significantly worse for the CHECK participants (p<0.001).Conclusion:Although both cohorts focus on the early phase of osteoarthritis, they differ significantly with respect to structural (radiographic) and clinical (health status) characteristics, CHECK expectedly representing participants in an even earlier phase of disease.

scholarly journals Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Nicola Veronese ◽  
Sinisa Stefanac ◽  
Ai Koyanagi ◽  
Nasser M. Al-Daghri ◽  
Shaun Sabico ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Muscle Mass ◽  
Lower Limbs ◽  
American People ◽  
Knee Oa ◽  
Skeletal Mass ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee ◽  
Significant Difference

Recent literature suggests that sarcopenia, often represented by low lower limbs muscle mass and strength, can be considered a potential risk factor for knee osteoarthritis (OA), but the available literature is still limited. We therefore aimed to investigate whether sarcopenia is associated with a higher risk of radiographic (ROA) and symptomatic knee OA (SxOA) in a large cohort of North American people in the context of the OA initiative. Sarcopenia at baseline was diagnosed in case of low skeletal muscle mass (i.e., lower skeletal mass index) and poor performance in the chair stands test. The outcomes of interest for this study included ROA (radiographical osteoarthritis) if a knee developed a Kellgren and Lawrence (KL) grade ≥2 at follow-up, and SxOA (symptomatic osteoarthritis) defined as new onset of a combination of painful knee OA. Altogether, 2,492 older participants (mean age: 68.4 years, 61.4% females) were included. At baseline, sarcopenia was present in 6.1% of the population. No significant difference in ROA prevalence was observed between those with and without sarcopenia (p=0.76), whilst people with sarcopenia reported a significant higher prevalence of SxOA (p&lt;0.0001). Using a logistic regression analysis, adjusting for potential confounders at baseline and the diagnosis of sarcopenia during follow-up, sarcopenia was associated with a higher incidence of knee SxOA (odds ratio, OR=2.29; 95%CI [confidence interval]: 1.42-3.71; p=0.001), but not knee ROA (OR=1.48; 95%CI: 0.53-4.10; p=0.45). In conclusion, sarcopenia could be associated with a higher risk of negative knee OA outcomes, in particular symptomatic forms.

scholarly journals Development of a model for predicting the 4-year risk of symptomatic knee osteoarthritis in China: a longitudinal cohort study

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Limin Wang ◽  
Han Lu ◽  
Hongbo Chen ◽  
Shida Jin ◽  
Mengqi Wang ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Risk Model ◽  
Characteristic Curve ◽  
Model Performance ◽  
Moderate Physical Activity ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

Abstract Objectives We aimed to develop a model for predicting the 4-year risk of knee osteoarthritis (KOA) based on survey data obtained via a random, nationwide sample of Chinese individuals. Methods Data was analyzed from 8193 middle-aged and older adults included in the China Health and Retirement Longitudinal Study (CHARLS). The incident of symptomatic KOA was defined as participants who were free of symptomatic KOA at baseline (CHARLS2011) and diagnosed with symptomatic KOA at the 4-year follow-up (CHARLS2015). The effects of potential predictors on the incident of KOA were estimated using logistic regression models and the final model was internally validated using the bootstrapping technique. Model performance was assessed based on discrimination—area under the receiver operating characteristic curve (AUC)—and calibration. Results A total of 815 incidents of KOA were identified at the 4-year follow-up, resulting in a cumulative incidence of approximately 9.95%. The final multivariable model included age, sex, waist circumference, residential area, difficulty with activities of daily living (ADLs)/instrumental activities of daily living (IADLs), history of hip fracture, depressive symptoms, number of chronic comorbidities, self-rated health status, and level of moderate physical activity (MPA). The risk model showed good discrimination with AUC = 0.719 (95% confidence interval [CI] 0.700–0.737) and optimism-corrected AUC = 0.712 after bootstrap validation. A satisfactory agreement was observed between the observed and predicted probability of incident symptomatic KOA. And a simple clinical score model was developed for quantifying the risk of KOA. Conclusion Our prediction model may aid the early identification of individuals at the greatest risk of developing KOA within 4 years.

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