scholarly journals AB0245 District differences between the sexes of predictive value of matrix metalloproteinase-3 at baseline regarding changes in modified total sharp score at 1 year in patients with rheumatoid arthritis

2017 ◽  
Author(s):  
K Inui ◽  
T Okano ◽  
K Orita ◽  
Y Sugioka ◽  
K Mamoto ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
Predictive Value ◽  
Matrix Metalloproteinase 3 ◽  
Sharp Score ◽  
Modified Total Sharp Score

scholarly journals Clinical significance of serum matrix metalloproteinase-3 level in patients with rheumatoid arthritis

Ensho Saisei ◽  
2005 ◽  
Vol 25 (1) ◽  
pp. 60-64 ◽  
Author(s):  
Hayato Nagasawa ◽  
Hideto Kameda ◽  
Koichi Amano ◽  
Tsutomu Takeuchi
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
Clinical Significance ◽  
Matrix Metalloproteinase 3

scholarly journals Possible involvement of matrix metalloproteinase-3 in the pathogenesis of macroprolactinaemia in some patients with rheumatoid arthritis

2013 ◽  
Vol 169 (2) ◽  
pp. 203-209 ◽  
Author(s):  
Takashi Adachi ◽  
Naoki Hattori ◽  
Takashi Ishihara ◽  
Hirokazu Iida ◽  
Takanori Saito ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
The Elderly ◽  
Elderly Subjects ◽  
Gel Chromatography ◽  
Post Translational Modifications ◽  
Matrix Metalloproteinase 3 ◽  
Control Subjects ◽  
Antibody Titres ◽  
And Gender

ObjectiveMacroprolactin primarily comprises a complex of prolactin (PRL) and IgG molecules, particularly anti-PRL autoantibodies. However, it is unknown why autoantibodies against PRL develop in certain subjects. This study aimed to elucidate post-translational modifications in the PRL molecule that may be involved in the pathogenesis of macroprolactinaemia.MethodsMacroprolactinaemia was screened with a polyethylene glycol method in 238 patients with rheumatoid arthritis (RA) and 302 control subjects and confirmed by gel chromatography. We examined the relationship between macroprolactinaemia and several RA-related laboratory tests including matrix metalloproteinase-3 (MMP-3) and anti-cyclic citrullinated peptide (CCP) antibody titres. The effect of MMP-3 on the PRL molecule was examined by western blotting.ResultsPatients with RA exhibited a significantly higher prevalence of macroprolactinaemia (15/238; 6.3%) than the young control subjects (5/219 subjects; 2.3%), but the prevalence was not different from that observed in the elderly control subjects (5/83 subjects; 6.0%). The prevalence of macroprolactinaemia in patients with elevated MMP-3 levels (9.68%) was significantly higher than that in those with normal MMP-3 levels (2.63%). Digestion of PRL with MMP-3 produced vasoinhibins with several molecular species. Serum total and free PRL levels in RA patients were higher than those in the age- and gender-matched control subjects. The levels of macroprolactin were not significantly correlated with those of RA-specific anti-CCP antibody.ConclusionsWe speculate that elevated MMP-3 levels may lead to the formation of new epitopes on the PRL molecule that might trigger an immune response to produce anti-PRL autoantibodies in some patients with RA. Such post-translational modifications may possibly contribute to the increased prevalence of macroprolactinaemia in elderly subjects.

AB0231 Elevation of Serum Matrix Metalloproteinase-3 in A Group of Rheumatoid Arthritis Algerian Patients

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 880.1-880
Author(s):  
D. Fodil ◽  
S.S. Salah ◽  
M. Benidir ◽  
S. Adjabi ◽  
M.C. Abbadi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 3
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