scholarly journals Neutrophil extracellular traps and low-density granulocytes are associated with the interferon signature in systemic lupus erythematosus, but not in antiphospholipid syndrome

2019 ◽  
Vol 79 (10) ◽  
pp. e135-e135 ◽  
Author(s):  
Lucas L van den Hoogen ◽  
Maarten van der Linden ◽  
Linde Meyaard ◽  
Ruth D E Fritsch-Stork ◽  
Joel A van Roon ◽  
...  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Meng Jiang ◽  
Nan Shen ◽  
Haibo Zhou ◽  
You Wang ◽  
Sihan Lin ◽  
...  

AbstractDespite the advances made in the management of pregnancies in women with systemic lupus erythematosus (SLE), the rate of adverse pregnancy outcomes is still higher than that in the general population. In the last few years, neutrophil extracellular traps (NETs) were proven to be detrimental in both autoimmune diseases and placental injury. We investigated whether NETs could be detected in the placentas of pregnant individuals with SLE and explored the relationship between NETs and decidual natural killer cells (dNKs), which comprise the majority of immune cells at the maternal–fetal interface, using clinical samples and animal models. In this study, we found that the infiltration of NETs and dNKs, especially CD56+CD16+ NK cells, was significantly increased in pregnant individuals with SLE with placental insufficiency. In the murine models of SLE, the number of dNKs was significantly decreased due to the decreased formation of NETs affected by Ly6G. Moreover, the histopathological placental injury was reduced, with a remarkable increase in fetal birth weight. This study shows that NETs may contribute to immunological disorder in the placenta and the pathological changes in pregnancies with SLE, which provides a research basis for further explorations of the mechanism of SLE in placental impairment.


2019 ◽  
Vol 39 (11) ◽  
pp. 1849-1857 ◽  
Author(s):  
Ivica Jeremic ◽  
Olivera Djuric ◽  
Milos Nikolic ◽  
Marina Vlajnic ◽  
Aleksandra Nikolic ◽  
...  

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii394-iii395
Author(s):  
Eleni A Frangou ◽  
Konstantinos Kambas ◽  
George Bertsias ◽  
Panayotis Verginis ◽  
Konstantinos Ritis ◽  
...  

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