scholarly journals SAT0166 GOLIMUMAB AS FIRST, SECOND OR AT LEAST THIRD BIOLOGIC AGENT IN PATIENTS WITH RHEUMATOID ARTHRITIS (RA), PSORIATIC ARTHRITIS (PSA) OR ANKYLOSING SPONDYLITIS (AS) – POST HOC ANALYSIS OF A NON-INTERVENTIONAL STUDY IN GERMANY

2019 ◽  
Author(s):  
Klaus Krueger ◽  
Gerd Rüdiger Burmester ◽  
Siegfried Wassenberg ◽  
Astrid Thiele ◽  
Matthias Thomas
Keyword(s):  
Rheumatoid Arthritis ◽  
Psoriatic Arthritis ◽  
Ankylosing Spondylitis ◽  
Biologic Agent ◽  
Interventional Study ◽  
Post Hoc Analysis ◽  
Post Hoc

scholarly journals AB1225 LIPID PROFILE COMPARISON IN RHEUMATOID ARTHRITIS AND PSORIATIC ARTHRITIS: A CASE-CONTROL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1904.2-1904
Author(s):  
D. Á. Galarza-Delgado ◽  
J. R. Azpiri-López ◽  
I. J. Colunga-Pedraza ◽  
A. Pérez Villar ◽  
I. C. Zárate Salinas ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Psoriatic Arthritis ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Classification Criteria ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Post Hoc Analysis ◽  
Post Hoc

Background:Rheumatoid arthritis (RA) and psoriasic arthritis (PsA) are autoimmune diseases, in both diseases it has been described that the main cause of morbidity and mortality is cardiovascular (CV) disease. Dyslipidemia is the most recognized CV risk factor. An association is recognized between the concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total triglycerides (TG), atherogenic index (AI) and the risk of myocardial infarction (MI), stroke and fatal cardiovascular disease (CVD). The relationship between serum lipid levels and CVD risk is potentially paradoxical in RA but this relationship has not been clarified in PsA.Objectives:To compare lipid profile between groups with RA, PsA and controls.Methods:A cross-sectional observational study was designed, which included 95 patients between 45-75 years who fulfilled the CASPAR classification criteria for PsA. 95 patients between 45-75 years who fulfilled the ACR / EULAR 2010 classification criteria for RA and 95 age-matched controls. Concentrations of CT, HDL-C, LDL-C, TG and atherogenic index were compared between the groups. Clinical measures were compared using one-way ANOVA or Kruskall-Wallis tests. Post-hoc analysis was performed with Bonferroni’s correction. Ap≤ 0.05 was considered statistically significant. The data was analyzed using the SPSS version 25 software package.Results:In our study, no significant difference in LDL-C was found between RA and PsA, however post-hoc analysis was performed where we found higher LDL-C levels among RA patients compared with controls (p0.025). RA patients had higher HDL-C than PsA patients (p0.006) but PsA had a higher HDL-C than controls (p0.007). TC/HDL-C was higher in PsA than RA and controls (p0.050). PsA patients were the group with the lowest HDL-C levels (p0.007). In contrast RA were the groups with the highest HDL-C levels (p0.007). (Table 1).Table 1.Clinical parameters.PARAMETERRAPsAControlspTC*176.6 ± 37.2176.3 ± 35.9186.34 ± 33.1720.089TG**132.7 (102.0-187.3)131.0 (97.2-189.2)118.35(88.2-162.25)0.245HDL-C**50.7 (42.1-62.6)46.7 (37.4-53.9)51.7 (41.3-60)0.007LDL-C*94.36 ± 21.7097.71 ± 30.12105.32 ±31.350.025TC/HDL-C**3.41 (2.81-4.08)3.74 (3.17-4.47)3.49 (2.99-4.52)0.050*Data are reported in mean ± SD**Data is reported in median (IQR)Conclusion:Patients with inflammatory joint diseases have more adverse lipid profiles than controls.References:[1]Pietrzak, A., Chabros, P., Grywalska, E., Kiciński, P., Pietrzak-Franciszkiewicz, K., Krasowska, D., & Kandzierski, G. (2019). Serum lipid metabolism in psoriasis and psoriatic arthritis–an update. Archives of medical science: AMS, 15(2), 369.Disclosure of Interests:None declared

Influence of intraoperative administration of glycopyrronium on early post-operative thirst, dry mouth and wellbeing. A post hoc analysis of an interventional study

2021 ◽  
pp. 103078
Author(s):  
Gregor Schittek ◽  
Gerold Schwantzer ◽  
Vasileios Papamargaritis ◽  
David Gebauer ◽  
Helmar Bornemann-Cimenti
Keyword(s):  
Dry Mouth ◽  
Interventional Study ◽  
Post Hoc Analysis ◽  
Post Hoc

scholarly journals POS0239 ROOT JOINT INVOLVEMENT IN SPONDYLOARTHRITIS: A POST-HOC ANALYSIS FROM THE INTERNATIONAL ASAS-PERSPA STUDY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 340.1-341
Author(s):  
N. Ziade ◽  
J. El-Hajj ◽  
J. Rassi ◽  
S. Hlais ◽  
C. López-Medina ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Positive Answer ◽  
Categorical Variables ◽  
Joint Involvement ◽  
Main Diagnosis ◽  
Post Hoc Analysis ◽  
Wall Distance ◽  
History Of ◽  
Axial Disease ◽  
Post Hoc

Background:In patients with spondyloarthritis (SpA), root joint diseases (RJD), i.e. hip or shoulder involvement, may be associated with a distinct disease phenotype compared to those with other affected joints. The ASAS-PerSpA study (PERipheral involvement in SPondyloArthritis) [1], offers a unique opportunity to study the phenotypes of patients with RJD in a global cohort.Objectives:Primary objective was to compare the clinical characteristics of SpA patients with and without RJD. Secondary objectives were to compare the prevalence of RJD across the different SpA subtypes and the different regions of the world, compare the severity of axial disease as well as the disease burden in SpA patients with and without RJD.Methods:This is a post-hoc analysis of the ASAS-PerSpA study, which included 4,465 patients with any subtype of SpA (axial SpA (axSpA), peripheral SpA (pSpA), psoriatic arthritis (PsA), inflammatory bowel disease associated SpA (IBD-SpA), reactive arthritis (ReA) and Juvenile SpA (Juv-SpA)) according to the rheumatologist’s diagnosis. RJD was defined as a positive answer by the investigator to the following question: “Do you consider that the patient has ever suffered from RJD (e.g. hip, shoulder) related to SpA?” In case of a positive answer, a potential specific treatment (e.g. Total Articular Replacement) was investigated. The patient’s characteristics were compared between those with and without RJD involvement, using Chi-2 or Fisher exact test for the categorical variables and t-test for the continuous variables. Two separate multivariable stepwise binary logistic regression analyses were conducted to identify factors associated with the dependent variables “hip involvement” and “shoulder involvement”.Results:RJD occurred in 1,503 patients (33.7%), with more prevalent hip (24.2%) than shoulder (13.2%) involvement. The prevalence of RJD as a group was the highest in Juv-SpA (52.7%), followed by pSpA (44.3%) and axSpA (33.9%). The highest prevalence of RJD was found in Asia and the lowest in Europe and North America. Among patients with hip involvement, 6.0% had a history of hip replacement (highest in the Middle East and North Africa and Latin America); among patients with shoulder involvement, 0.8% had a history of shoulder replacement. Hip had a distinct pattern of associations compared to shoulder involvement (Figure 1). Hip involvement was significantly associated with the SpA main diagnosis (highest in pSpA, lowest in PsA), younger age at first SpA symptom, lower prevalence of family history of psoriasis, positive HLA-B27, occiput-to-wall distance>0, and treatment with cs-DMARDs and b-DMARDs. Shoulder involvement was associated with the SpA main diagnosis (highest in Juv-SpA and pSpA, lowest in axSpA), older age at first SpA symptom, higher prevalence of enthesitis, dactylitis, tender joints count, IBD, occiput-to-wall distance>0, EQ5D score and treatment with cs-DMARDs.Conclusion:Hip involvement was more prevalent than shoulder involvement in patients with SpA, and had a distinct phenotype resembling axial disease whereas shoulder involvement was mostly associated with features of peripheral disease. Hip and shoulder involvement should be analyzed separately in future studies rather than under the RJD entity.References:[1]Lopez-medina, C. et al. Prevalence and Distribution of Peripheral Musculoskeletal Manifestations in Axial Spondyloarthritis, Peripheral Spondyloarthritis and Psoriatic Arthritis: Results of the International, Cross-sectional ASAS-PerSpA Study. RMD Open; 2021;7:e001450.Disclosure of Interests:None declared

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