Cerebral oxygenation and echocardiographic parameters in preterm neonates with a patent ductus arteriosus: an observational study

2016 ◽  
Vol 101 (6) ◽  
pp. F520-F526 ◽  
Author(s):  
Laura Dix ◽  
Mirella Molenschot ◽  
Johannes Breur ◽  
Willem de Vries ◽  
Daniel Vijlbrief ◽  
...  
Keyword(s):  
Observational Study ◽  
Patent Ductus Arteriosus ◽  
Cerebral Oxygenation ◽  
Ductus Arteriosus ◽  
Preterm Neonates ◽  
Echocardiographic Parameters ◽  
Patent Ductus

scholarly journals Brain and renal oxygenation measured by NIRS related to patent ductus arteriosus in preterm infants: a prospective observational study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jurate Navikiene ◽  
Ernestas Virsilas ◽  
Ramune Vankeviciene ◽  
Arunas Liubsys ◽  
Augustina Jankauskiene
Keyword(s):  
Observational Study ◽  
Patent Ductus Arteriosus ◽  
Preterm Infants ◽  
Prospective Observational Study ◽  
Cerebral Oxygenation ◽  
Ductus Arteriosus ◽  
Oxygen Extraction ◽  
Tissue Oxygen ◽  
Link Type ◽  
Patent Ductus

Abstract Background Patent ductus arteriosus (PDA) is common among preterm neonates. Haemodynamically significant ductus arteriosus (hsPDA) can cause ductal steal and contribute to poor outcomes. Our aim was to evaluate ductus arteriosus patency and significance using two-site near-infrared spectroscopy (NIRS) measurements in preterm infants older than 72 h as a supplemental tool to echocardiography. Methods In this prospective observational study, 123 preterm infants (gestational age (GA) < 32 weeks, birth weight < 1500 g) were enrolled. Sixty-four newborns had closed ductus arteriosus (noPDA), and 41 and 18 patients were assigned to the PDA and hsPDA groups, respectively, per predefined echocardiographic criteria. Cerebral and renal oxygenation were assessed during NIRS monitoring. Results A higher renal mean (±SD) regional tissue oxygen saturation (rSpO2) (76.7 (±7.64)) was detected in the noPDA group than in the PDA (71.7 (±9.02)) and hsPDA (67.4 (±13.48)) groups (p < 0.001). Renal fractional tissue oxygen extraction (FTOE) (0.18 (±0.079)) was lower in the noPDA group than in the PDA (0.23 (±0.092)) and hsPDA (0.24 (±0.117))0.117 groups (p = 0.002). Cerebral oxygenation was significantly lower in the hsPDA group (77.0 (±5.16)) than in the noPDA (79.3 (±2.45)) and PDA (79.7 (±2.27)) groups (p = 0.004). There was no significant difference in cerebral fractional tissue oxygen extraction (FTOE) between any of the groups. Conclusions Our results suggest that renal oxygenation is affected by ductus patency in preterm infants older than 72 h. Significant differences in cerebral oxygenation were observed between the hsPDA group and the PDA and noPDA groups. Trial registration ClinicalTrials.gov Identifier: NCT04295395. Registration date: 4 March 2020. This study was retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04295395.

Echocardiographic parameters of patent ductus arteriosus in preterm infants

2011 ◽  
Vol 48 (10) ◽  
pp. 773-778 ◽  
Author(s):  
A. Khositseth ◽  
P. Nuntnarumit ◽  
P. Chongkongkiat
Keyword(s):  
Patent Ductus Arteriosus ◽  
Preterm Infants ◽  
Ductus Arteriosus ◽  
Echocardiographic Parameters ◽  
Patent Ductus

Oral acetaminophen administration for patent ductus arteriosus (PDA) closure in preterm neonates

2021 ◽  
Vol 43 (3) ◽  
pp. 254-259
Author(s):  
Mahmood Samadi ◽  
Zahra Nabaee ◽  
Manizheh Mostafagharebaghi ◽  
Majid Mahalei ◽  
Elham Sheykhsaran ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Gestational Age ◽  
Statistical Significance ◽  
Ductus Arteriosus ◽  
Preterm Neonates ◽  
Term Infants ◽  
Treatment Data ◽  
Kolmogorov Smirnov ◽  
Study Population ◽  
Patent Ductus

Background: Patent Ductus Arteriosus (PDA) is considered one of the most prevalent types of congenital heart disease. The closure of the ductus arteriosus physiologically occurs at the first 48-72 hours after the birth in healthy term infants. Different causes can result in the pathological opening of ductus arteriosus. This study aims to investigate the effect of oral acetaminophen on the closure of PDA in preterm neonates. Methods: The present study is a trial without control. Forty-five preterm neonates with a gestational age of <32 weeks were studied. Acetaminophen was orally administered with a dose of 10mg/kg every 6 hours for three days. Closure of ductus arteriosus was considered as the success of treatment. Data were analyzed using SPSS 15. Data were reported as )frequency-percent) and mean ± SD. To evaluate the normal distribution of data, we used a Kolmogorov-Smirnov test. Statistical significance was defined as P<0.05. Results: The study population consisted of 20 male and 25 female infants with the mean gestational age of 28.95 ± 1.66 weeks. Cesarean-born infants and vaginal-born infants consisted 17.8% and 82.2% of the study population, respectively. The proportion of PDA closure after administration of oralacetaminophen was 82.3%. Conclusion: The current study indicates that oral acetaminophen is highly effective in closing PDA. Considering its trivial side effects, it has the potency to be a convenient option for treating this condition.

scholarly journals The effect of ductal diameter on surgical and medical closure of patent ductus arteriosus in preterm neonates: Size matters

2008 ◽  
Vol 135 (1) ◽  
pp. 78-82 ◽  
Author(s):  
Scott Tschuppert ◽  
Carsten Doell ◽  
Romaine Arlettaz-Mieth ◽  
Oskar Baenziger ◽  
Valentin Rousson ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Preterm Neonates ◽  
Patent Ductus
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