Co-infection of intestinal tuberculosis and mucormycosis in a patient with Down syndrome: a unique case report with literature review

2021 ◽  
Vol 14 (11) ◽  
pp. e244903
Author(s):  
Bishal Pal ◽  
Ketavath Thirupathaiah ◽  
Bhawana Ashok Badhe ◽  
Vishnu Prasad Nelamangala Ramakrishnaiah ◽  
Souradeep Dutta ◽  
...  
Keyword(s):  
Immune Response ◽  
Down Syndrome ◽  
Case Report ◽  
Rare Case ◽  
Intestinal Tuberculosis ◽  
Haematological Malignancies ◽  
Unique Case ◽  
Impaired Immune Response ◽  
Small Intestinal

Mucormycosis represents several unusual opportunistic infection caused by saprophytic aseptate fungi. There is a recent rise in cases of mucormycosis due to an increase in diabetic and immunodeficient patients like patients on long-term steroids, immunomodulators due to organ transplantation, malignancies, mainly haematological malignancies, and autoimmunity. Anatomically, mucormycosis can be localised most commonly as rhino-orbito-cerebral followed by pulmonary, disseminated, cutaneous and gastrointestinal, rarest being small intestinal. Patients with Down syndrome are immunodeficient due to their impaired immune response. Disseminated tuberculosis is also common in immunodeficient patients. We report a rare case of small intestinal mucormycosis in a patient with Down syndrome with coexisting intestinal tuberculosis. Due to the invasiveness of mucormycosis, the patient succumbed to death despite providing aggressive surgical debridement and medical management.

scholarly journals Phenylketonuria and juvenile idiopathic arthritis: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ting Ting Zhu ◽  
Jin Wu ◽  
Li Yuan Wang ◽  
Xiao Mei Sun
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Case Report ◽  
Autoimmune Diseases ◽  
Hip Joint ◽  
Metabolic Disorder ◽  
Rare Case ◽  
Molecular Data ◽  
Methotrexate Therapy ◽  
Case Presentation

Abstract Background Phenylketonuria (PKU) is a genetic metabolic disorder in which patients have no ability to convert phenylalanine to tyrosine. Several autoimmune diseases have been reported to combine with PKU, co-existent of PKU and Juvenile Idiopathic Arthritis (JIA) has not been presented. Case presentation The girl was diagnosed with PKU at the age of 1 month confirmed by molecular data. At the age of 3.5 years, she presented with pain and swelling of her right ankle, right knee, and right hip joint. After a serial of examinations, she was diagnosed with JIA and treated with a nonsteroidal anti-inflammatory drug. Conclusions We report a rare case of a 4-year-old girl with PKU and JIA, which supports a possible interaction between PKU and JIA. Long-term metabolic disturbance may increase the susceptibility to JIA. Further chronic inflammation could alter the metabolism of tryptophan and tyrosine to increase blood Phe concentration. In addition, corticosteroid and methotrexate therapy for JIA may increase blood Phe concentration.

scholarly journals Juvenile Aggressive Trabecular Ossifying Fibroma of Mandible: A Rare Case Report

2016 ◽  
Vol 6 (1) ◽  
pp. 45-51
Author(s):  
Deepa Das Achath ◽  
Abhishek Sanjay Ghule ◽  
Preeti Kanchan-Talreja ◽  
Sunanda Bhatnagar
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Histological Analysis ◽  
High Recurrence Rate ◽  
Ossifying Fibroma ◽  
Appropriate Treatment ◽  
Juvenile Ossifying Fibroma ◽  
Rare Case Report

ABSTRACT Fibroosseous lesions of the jaws, including juvenile ossifying fibroma (JOF), pose diagnostic and therapeutic difficulties due to their clinical, radiological, and histological variability. There are two histological varieties of it, one as psammomatoid type and second as trebacular type; here, we present a trebacular type, which is a rare variety. After the clinical examination, radiological and histological analysis, it was diagnosed as juvenile trebacular ossifying fibroma. Although JOF is an uncommon clinical entity, its aggressive local behavior and high recurrence rate means that it is important to make an early diagnosis, apply the appropriate treatment, and, especially, follow-up the patient over the long term. How to cite this article Ghule AS, Achath DD, Kanchan- Talreja P, Bhatnagar S. Juvenile Aggressive Trabecular Ossifying Fibroma of Mandible: A Rare Case Report. J Contemp Dent 2016;6(1):45-51.

scholarly journals A CASE REPORT ON MULTISYSTEMIC INFLAMMATORY SYNDROME- CHILDREN HOW THE DIAGNOSIS AND TREATMENT COULD BE CHALLENGING

2021 ◽  
Vol 9 (11) ◽  
pp. 183-187
Author(s):  
S.U. Basnayake ◽  
◽  
T.G Dissanayakege ◽  
Keyword(s):  
Immune Response ◽  
Case Report ◽  
Young Child ◽  
Treatment Options ◽  
Severe Illness ◽  
Immunological Reaction ◽  
Case Definitions ◽  
Diagnosis And Management ◽  
Inflammatory Syndrome

Although COVID 19 infections in children are generally mild and non-fatal, there is increasing recognition of a multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, leading to severe illness and long-term sequelae. Even though there is some evidence that the MIS-C is a post-viral immunological reaction to COVID-19, understanding of the immune response induced by SARS-CoV-2 remains unclear.Various local and international guidelines are being widely practiced in the diagnosis and management of patients with MIS-C. A case report of a young child who was diagnosed and managed as MIS-C is discussed here. The diagnostic challenges with the available case definitions and currently accepted treatment options are elaborated herein.

scholarly journals AGGRESSIVE MESENTRIC FIBROMATOSIS: A RARE CASE REPORT AND REVIEW OF LITERATURE

2013 ◽  
Vol 03 (01) ◽  
pp. 79-82
Author(s):  
Rohan Shetty ◽  
Shubha Bhat ◽  
Rajesh Ballal ◽  
Pramod Makannavar ◽  
Anil Kumar K. N.
Keyword(s):  
Case Report ◽  
Male Patient ◽  
Rare Case ◽  
Clinical Presentation ◽  
Aggressive Fibromatosis ◽  
Definitive Diagnosis ◽  
Review Of Literature ◽  
Therapeutic Challenge ◽  
Rare Case Report ◽  
Small Intestinal

AbstractMesentric fibromatosis is a proliferative fibroblastic neoplasm of the small intestinal mesentery with varied clinical presentation. Giant mesentric fibromatosis is uncommon and its rarity poses a diagnostic and therapeutic challenge. This paper presents a recurrent aggressive fibromatosis in a 38 year old male patient, who had initially undergone a laparotomy outside for mass abdomen but only pus was evacuated and definitive diagnosis was not made.

scholarly journals A maxillary ameloblastic fibrosarcoma tumor: a rare case report from Syria

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Amjad Soltany ◽  
Ghazal Asaad ◽  
Rami Daher ◽  
Mouhannad Dayoub ◽  
Ali Khalil ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Rare Case ◽  
Soft Tissue Sarcomas ◽  
Surgical Excision ◽  
Low Grade ◽  
Rare Case Report ◽  
Ameloblastic Fibrosarcoma ◽  
The Right

Abstract Ameloblastic fibrosarcoma (AFS) is a rare, aggressive malignant odontogenic tumor. AFS is seen most frequently in second and third decades of life. We are reporting a case of a low grade AFS in a 21-year-old male complaining of a painless swelling in the right side of the maxilla. The patient was treated with surgical excision followed by radiotherapy, which is considered the most effective approach for most of soft tissue sarcomas. AFS has a high-reported recurrence rate (up to 37%); therefore, long-term surveillance for recurrence is crucial.

scholarly journals Spontaneous biloma due to an intrahepatic cholangiocarcinoma: An extremely rare case report with long term survival and literature review

2017 ◽  
Vol 14 ◽  
pp. 36-39 ◽  
Author(s):  
Georgios K. Georgiou ◽  
Athina Tsili ◽  
Anna Batistatou ◽  
Alexandra Papoudou-Bai ◽  
Georgios Papadopoulos ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Intrahepatic Cholangiocarcinoma ◽  
Rare Case ◽  
Term Survival ◽  
Long Term Survival ◽  
Rare Case Report

scholarly journals Cystic Lung Disease in Down Syndrome: A Case Report and Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Mathew George ◽  
John Amodio ◽  
Haesoon Lee
Keyword(s):  
Congenital Heart Disease ◽  
Down Syndrome ◽  
Case Report ◽  
Congenital Heart ◽  
Endocardial Cushion ◽  
Lung Cysts ◽  
Children With Down Syndrome ◽  
Cystic Lung ◽  
Endocardial Cushion Defect

Subpleural lung cysts (SPC) are seen in children with Down syndrome (DS). The incidence and the long term course of these lesions are not known. It is important for pediatricians and pediatric radiologists to be aware of these lung lesions since the DS patients’ longevity has increased and they have greater frequency to encounter the clinicians. Autopsy and the radiology series have shown that these lesions are often found in association with congenital heart disease, particularly the endocardial cushion defect and prematurity.

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