scholarly journals Assessing the health effects associated with occupational radiation exposure in Korean radiation workers: protocol for a prospective cohort study

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e017359 ◽  
Author(s):  
Songwon Seo ◽  
Wan Young Lim ◽  
Dal Nim Lee ◽  
Jung Un Kim ◽  
Eun Shil Cha ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Risk ◽  
Radiation Exposure ◽  
Health Effects ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Low Dose ◽  
Occupational Radiation Exposure ◽  
Radiation Workers ◽  
Occupational Radiation

IntroductionThe cancer risk of radiation exposure in the moderate-to-high dose range has been well established. However, the risk remains unclear at low-dose ranges with protracted low-dose rate exposure, which is typical of occupational exposure. Several epidemiological studies of Korean radiation workers have been conducted, but the data were analysed retrospectively in most cases. Moreover, groups with relatively high exposure, such as industrial radiographers, have been neglected. Therefore, we have launched a prospective cohort study of all Korean radiation workers to assess the health effects associated with occupational radiation exposure.Methods and analysisApproximately 42 000 Korean radiation workers registered with the Nuclear Safety and Security Commission from 2016 to 2017 are the initial target population of this study. Cohort participants are to be enrolled through a nationwide self-administered questionnaire survey between 24 May 2016 and 30 June 2017. As of 31 March 2017, 22 982 workers are enrolled in the study corresponding to a response rate of 75%. This enrolment will be continued at 5-year intervals to update information on existing study participants and recruit newly hired workers. Survey data will be linked with the national dose registry, the national cancer registry, the national vital statistics registry and national health insurance data via personal identification numbers. Age-specific and sex-specific standardised incidence and mortality ratios will be calculated for overall comparisons of cancer risk. For dose–response assessment, excess relative risk (per Gy) and excess absolute risk (per Gy) will be estimated with adjustments for birth year and potential confounders, such as lifestyle factors and socioeconomic status.Ethics and disseminationThis study has received ethical approval from the institutional review board of the Korea Institute of Radiological and Medical Sciences (IRB No. K-1603-002-034). All participants provided written informed consent prior to enrolment. The findings of the study will be disseminated through scientific peer-reviewed journals and be provided to the public, including radiation workers, via the study website (http://www.rhs.kr/) and onsite radiation safety education.

scholarly journals Occupational radiation exposure and its health effects on interventional medical workers: study protocol for a prospective cohort study

BMJ Open ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. e018333 ◽  
Author(s):  
Seulki Ko ◽  
Hwan Hoon Chung ◽  
Sung Bum Cho ◽  
Young Woo Jin ◽  
Kwang Pyo Kim ◽  
...  
Keyword(s):  
Cohort Study ◽  
Radiation Exposure ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Occupational Radiation Exposure ◽  
Radiation Workers ◽  
Occupational Radiation

IntroductionAlthough fluoroscopically guided procedures involve a considerably high dose of radiation, few studies have investigated the effects of radiation on medical workers involved in interventional fluoroscopy procedures. Previous research remains in the early stages and has not reached a level comparable with other occupational studies thus far. Furthermore, the study of radiation workers provides an opportunity to estimate health risks at low doses and dose rates of ionising radiation. Therefore, the objectives of this study are (1) to initiate a prospective cohort study by conducting a baseline survey among medical radiation workers who involve interventional fluoroscopy procedures and (2) to assess the effect of occupational radiation exposure and on the overall health status through an in-depth cross-sectional study.Methods and analysisIntervention medical workers in Korea will be enrolled by using a self-administered questionnaire survey, and the survey data will be linked with radiation dosimetry data, National Health Insurance claims data, cancer registry and mortality data. After merging these data, the radiation organ dose, lifetime attributable risk due to cancer and the risk per unit dose will be estimated. For the cross-sectional study, approximately 100 intervention radiology department workers will be investigated for blood tests, clinical examinations such as ultrasonography (thyroid and carotid artery scan) and lens opacity, the validation of badge dose and biodosimetry.Ethics and disseminationThis study was reviewed and approved by the institutional review board of Korea University (KU-IRB-12-12-A-1). All participants will provide written informed consent prior to enrolment. The findings of the study will be disseminated through peer-reviewed scientific journals, conference presentations, and a report will be submitted to the relevant public health authorities in the Korea Centers for Disease Control and Prevention to help with the development of appropriate research and management policies.

Cynical distrust increases breast cancer risk: Evidence from a prospective cohort study

2002 ◽  
Author(s):  
A. R. Aro ◽  
H. J. de Koning ◽  
K. Vehkalahti ◽  
P. Absetz ◽  
M. Schreck ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Prospective Cohort Study ◽  
Prospective Cohort

T1958 Recurrent Ulcer Bleeding with Use of Low-Dose Aspirin After Eradication of H. pylori: An 8-Year Prospective Cohort Study

2009 ◽  
Vol 136 (5) ◽  
pp. A-609
Author(s):  
Francis K.L. Chan ◽  
Jessica Ching ◽  
Bing Yee Suen ◽  
Justin Wu ◽  
Vincent W. Wong ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Low Dose ◽  
Ulcer Bleeding ◽  
Recurrent Ulcer ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
H Pylori

Impact of considering non-occupational radiation exposure on the association between occupational dose and solid cancer among French nuclear workers

2017 ◽  
Vol 75 (3) ◽  
pp. 199-204 ◽  
Author(s):  
Lucie Fournier ◽  
Enora Cléro ◽  
Eric Samson ◽  
Sylvaine Caër-Lorho ◽  
Dominique Laurier ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Cancer Risk ◽  
Radiation Exposure ◽  
Cancer Mortality ◽  
Environmental Radiation ◽  
Occupational Radiation Exposure ◽  
X Ray ◽  
Work Related ◽  
The Mean ◽  
Occupational Radiation

ObjectivesThe French nuclear worker cohort allows for the assessment of cancer risk associated with occupational radiation exposure, but workers are also exposed to medical and environmental radiation which can be of the same order of magnitude. This study aims to examine the impact of non-occupational radiation exposures on the dose-risk analysis between occupational radiation exposure and cancer mortality.MethodsThe cohort included workers employed before 1995 for at least one year by CEA, AREVA NC or EDF and badge-monitored for external radiation exposure. Monitoring results were used to calculate occupational individual doses. Scenarios of work-related X-ray and environmental exposures were simulated. Poisson regression was used to quantify associations between occupational exposure and cancer mortality adjusting for non-occupational radiation exposure.ResultsThe mean cumulative dose of external occupational radiation was 18.4 mSv among 59 004 workers. Depending on the hypotheses made, the mean cumulative work-related X-ray dose varied between 3.1 and 9.2 mSv and the mean cumulative environmental dose was around 130 mSv. The unadjusted excess relative rate of cancer per Sievert (ERR/Sv) was 0.34 (90% CI −0.44 to 1.24). Adjusting for environmental radiation exposure did not substantially modify this risk coefficient, but it was attenuated by medical exposure (ERR/Sv point estimate between 0.15 and 0.23).ConclusionsOccupational radiation risk estimates were lower when adjusted for work-related X-ray exposures. Environmental exposures had a very slight impact on the occupational exposure risk estimates. In any scenario of non-occupational exposure considered, a positive but insignificant excess cancer risk associated with occupational exposure was observed.

scholarly journals Measured cardiorespiratory fitness and self‐reported physical activity: associations with cancer risk and death in a long‐term prospective cohort study

2016 ◽  
Vol 5 (8) ◽  
pp. 2136-2144 ◽  
Author(s):  
Trude E. Robsahm ◽  
Ragnhild S. Falk ◽  
Trond Heir ◽  
Leiv Sandvik ◽  
Linda Vos ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Cancer Risk ◽  
Cardiorespiratory Fitness ◽  
Prospective Cohort Study ◽  
Prospective Cohort

scholarly journals Cholesterol and prostate cancer risk: a long-term prospective cohort study

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Trond Heir ◽  
Ragnhild Sørum Falk ◽  
Trude Eid Robsahm ◽  
Leiv Sandvik ◽  
Jan Erikssen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Prostate Cancer Risk

scholarly journals Correction: Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0201078 ◽  
Author(s):  
Sharon L. McDonnell ◽  
Carole Baggerly ◽  
Christine B. French ◽  
Leo L. Baggerly ◽  
Cedric F. Garland ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Risk ◽  
Randomized Trial ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Pooled Analysis ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D
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