scholarly journals 5PSQ-158 Off-label use of pembrolizumab in PD-L1 positive metastatic anaplastic thyroid carcinoma: a case report

Author(s):  
SMA Giordano ◽  
M Scaldaferri ◽  
E Caiazza ◽  
F Cattel
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R Guerrero Bautista ◽  
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Ben J. Wilson

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A Ganfornina Andrades ◽  
MDC Jiménez De-Juan ◽  
A Salguero Olid ◽  
MJ Fernández Anguita

2021 ◽  
Vol 13 (1) ◽  
pp. 59-69
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D. L. Sulima ◽  
A. A. Yakovlev ◽  
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V. A. Larionov ◽  
O. V. Gorchakova ◽  
...  

For the first time in Russia, a description of a case of full application in clinical practice of a completely interferon-free mode of the 3D-mode GLE/PIB + SOF for the treatment of recurrence of HCV 1b RNA viremia after a primary course of interferonfree therapy in the PTV/r/OBV + DSV mode, which included inhibitors of NS3/4A PI, NS5Ai and NS5Bi, in a patient with combined HCV syndrome is presented. The target result of the repeated course of interferon-free therapy — SVR12 — was achieved despite the presence of significant RAS R117H in the NS3 region of the HCV genome and multiple RASs in the NS3 and NS5A regions, the nature of resistance of which to the corresponding inhibitors of GLE and PIB was unknown. Along with a complete virological response, the treatment also achieved a complete immunological response, which lasted for 12 weeks after the end of the repeated course of interferon-free therapy.


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