scholarly journals 442 Risk reduction salpingo-oophorectomy in BRCA mutation carriers. Presurgical and pathology findings. A prospective cohort study

2021 ◽  
Author(s):  
MDLR Oliver ◽  
S Aragon-Sanchez ◽  
L Alvaro ◽  
M De Miguel-Reyes ◽  
E Felipe-Pardo ◽  
...  
Keyword(s):  
Cohort Study ◽  
Risk Reduction ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Brca Mutation ◽  
Mutation Carriers ◽  
Brca Mutation Carriers

Impact of prophylactic bilateral salpingo-oophorectomy on bone health in BRCA mutation carriers: A prospective cohort study.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 1566-1566
Author(s):  
Elizabeth Hall ◽  
Joanne Kotsopoulos ◽  
Amy Finch ◽  
Islay Thompson ◽  
Barry Rosen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Bone Health ◽  
Prospective Cohort ◽  
Brca Mutation ◽  
Mutation Carriers ◽  
Brca Mutation Carriers

scholarly journals Multifactorial individualised programme for hamstring muscle injury risk reduction in professional football: protocol for a prospective cohort study

2020 ◽  
Vol 6 (1) ◽  
pp. e000758
Author(s):  
Johan Lahti ◽  
Jurdan Mendiguchia ◽  
Juha Ahtiainen ◽  
Luis Anula ◽  
Tuomas Kononen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Risk Reduction ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Injury Risk ◽  
Cox Regression ◽  
University Hospital ◽  
Professional Football ◽  
Hamstring Muscle ◽  
Cox Regression Analysis

IntroductionHamstring muscle injuries (HMI) continue to plague professional football. Several scientific publications have encouraged a multifactorial approach; however, no multifactorial HMI risk reduction studies have been conducted in professional football. Furthermore, individualisation of HMI management programmes has only been researched in a rehabilitation setting. Therefore, this study aims to determine if a specific multifactorial and individualised programme can reduce HMI occurrence in professional football.Methods and analysisWe conducted a prospective cohort study over two seasons within the Finnish Premier League and compare the amount of HMI sustained during a control season to an intervention season. Injury data and sport exposure were collected during the two seasons (2019–2020), and a multifactorial and individualised HMI risk reduction programme will be implemented during intervention season (2020). After a hamstring screening protocol is completed, individual training will be defined for each player within several categories: lumbo-pelvic control, range of motion, posterior chain strength, sprint mechanical output and an additional non-individualised ‘training for all players’ category. Screening and respective updates to training programmes were conducted three times during the season. The outcome will be to compare if there is a significant effect of the intervention on the HMI occurrence using Cox regression analysis.Ethics and disseminationApproval for the injury and sport exposure data collection was obtained by the Saint-Etienne University Hospital Ethics Committee (request number: IORG0007394; record number IRBN322016/CHUSTE). Approval for the intervention season was obtained from the Central Finland healthcare District (request and record number: U6/2019).

Risk reduction and survival benefit of prophylactic surgery in BRCA mutation carriers, a systematic review

2016 ◽  
Vol 212 (4) ◽  
pp. 660-669 ◽  
Author(s):  
Kandice K. Ludwig ◽  
Joan Neuner ◽  
Annabelle Butler ◽  
Jennifer L. Geurts ◽  
Amanda L. Kong
Keyword(s):  
Systematic Review ◽  
Risk Reduction ◽  
Survival Benefit ◽  
Brca Mutation ◽  
Prophylactic Surgery ◽  
Mutation Carriers ◽  
Brca Mutation Carriers

Risk-reduction surgery in BRCA mutation carriers in a Spanish population: adherence and results

2008 ◽  
Vol 10 (10) ◽  
pp. 660-664 ◽  
Author(s):  
Pedro Pérez Segura ◽  
Paula Jiménez ◽  
Helena Olivera ◽  
Raquel Andrés Conejero ◽  
Trinidad Caldés ◽  
...  
Keyword(s):  
Risk Reduction ◽  
Brca Mutation ◽  
Spanish Population ◽  
Mutation Carriers ◽  
Brca Mutation Carriers

Factors influencing risk reduction surgery among BRCA mutation carriers: A qualitative analysis.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 53-53 ◽  
Author(s):  
Rachael Brandt ◽  
Cristina Polinsky ◽  
Jessica Katz ◽  
Minal Dhamankar ◽  
Rosemarie Tucci ◽  
...  
Keyword(s):  
High Risk ◽  
Qualitative Analysis ◽  
Risk Reduction ◽  
Surgical Intervention ◽  
Brca Mutation ◽  
Carrier Status ◽  
Care Providers ◽  
Factors Influencing ◽  
Mutation Carriers ◽  
Brca Mutation Carriers

53 Background: Women known to carry deleterious mutations in BRCA1 and BRCA2 have a substantially increased lifetime risk to develop breast and ovarian cancer. Current risk management options include increased surveillance, chemoprevention and risk reducing surgery. Several studies have quantitatively evaluated the reasoning of high risk women for electing surgical intervention, noting mutation carrier status as a significant, but not sole rationale for this decision. The decision for surgery has also been associated with family cancer history, anxiety, demographics, healthcare setting and prior counseling. More insights regarding factors influencing women’s choice for risk reduction are needed. Methods: To further assess factors influencing the decision to have risk reduction surgery among women in a community hospital system, 129 BRCA mutation carriers in a community-based genetic counseling program were invited to participate in a qualitative study using questionnaires. A thematic analysis was performed by two independent reviewers on open dialogue responses. Results: Of the 59 respondents, 54 completed the question specifically addressing factors regarding the decision on surgery. Of them, 32 opted for mastectomy, salpingo-oophorectomy or both and 22 opted against surgical risk reduction. Themes emerging in support of surgery included: vicarious experience attributable to a strong family history of cancer; desire for control over risk through surgical intervention; high risk perception; co-morbidities; desire for living, regarding longevity and for loved ones; fear of cancer; and skepticism related to cancer detection methods. For women opting against surgery, themes included: co-morbidities; age (too old/young); incomplete childbearing; logistics (scheduling, finances); lack of disease; and skepticism in effectiveness of surgery. Conclusions: While various factors have been studied regarding the association with or probability of women’s decisions for risk reduction surgery, a deeper comprehension of women’s reasoning can be attained through qualitative analysis. This understanding may enhance health care providers’ ability to counsel women regarding this choice.

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