Adverse reactions to metal debris: histopathological features of periprosthetic soft tissue reactions seen in association with failed metal on metal hip arthroplasties

2012 ◽  
Vol 65 (5) ◽  
pp. 409-418 ◽  
Author(s):  
Sonali Natu ◽  
Raghavendra Prasad Sidaginamale ◽  
Jamshid Gandhi ◽  
David J Langton ◽  
Antoni V F Nargol
2013 ◽  
Vol 95 (4) ◽  
pp. 266-270 ◽  
Author(s):  
MA Kemp ◽  
A Mitra ◽  
T Mendes da Costa ◽  
RF Spencer

Introduction Soft tissue reactions following metal-on-metal (MoM) arthroplasty of the hip have been under considerable discussion. These reactions are seen following both hip resurfacing and MoM total hip arthroplasty (THA). The phenomenon may arise owing to shedding of metal particles in high wear states, hypersensitivity with normal metal wear rates or a combination of the two. Methods Three patients were identified who had developed a soft tissue reaction (pseudotumour) following MoM hip resurfacing procedures. The prostheses were revised to ceramic-on-ceramic (CoC) THA with only minimal debridement of the pseudotumour. Pre and postoperative magnetic resonance imaging was performed to assess the size of the lesions. Results Progressive and satisfactory resolution of the associated pseudotumours was identified following revision of the prostheses to CoC THA. Conclusions In the early stages of pseudotumour formation following MoM hip resurfacing, this potentially devastating condition can be managed adequately with revision to a CoC bearing THA with minimal soft tissue excision.


2018 ◽  
Vol 89 (3) ◽  
pp. 278-288 ◽  
Author(s):  
Gulraj S Matharu ◽  
Antti Eskelinen ◽  
Andrew Judge ◽  
Hemant G Pandit ◽  
David W Murray

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
W. Maurer-Ertl ◽  
D. Pranckh-Matzke ◽  
J. Friesenbichler ◽  
G. Bratschitsch ◽  
L. A. Holzer ◽  
...  

Background. Increased metal ion levels following total hip arthroplasty (THA) with metal-on-metal bearings are a highly debated topic. Local soft tissue reactions with chronic pain and systemic side effects such as neuropathy are described. The aim of the current study was to determine the serum metal ion concentrations of Cobalt (Co) and Chrome (Cr) after THA with a ceramic-on-metal (CoM) bearing. Patients and Methods. Between 2008 and 2010, 20 patients underwent THA using a CoM bearing. Clinical function was evaluated by standardized scores systems (Harris Hip Score and WOMAC Score) and radiological examination included X-rays. Patient’s blood samples were obtained for metal ion analysis and correlation analysis was done between these results and implant position. Results. Overall, 13 patients with 14 CoM devices were available for the current series. The mean age at time of surgery was 61 years (range, 41 to 85). The postoperative follow-up ranged from 49 to 68 months (mean, 58). Metal ion determination showed mean concentrations of 3,1 µg/L (range, 0,3–15,2 µg/L) for Co and 1,6 µg/L (range, 0,1–5,5 µg/L) for Cr, respectively. A correlation between cup anteversion and Co and Cr concentrations was shown. Conclusion. The current series showed increments for Co and Cr following CoM THA. However, these levels are lower compared to metal ion concentrations in patients with metal-on-metal bearings and the international accepted threshold for revision of MoM devices. We recommend routine follow-up including at least one obligatory evaluation of serum metal ion concentrations and an MRI once to exclude local soft tissue reactions.


2021 ◽  
Vol 9 ◽  
pp. 205031212110147
Author(s):  
Nobuhiko Sumiyoshi ◽  
Kazuhiro Oinuma ◽  
Yoko Miura

Background: Adverse reactions to metal debris are significant complications after metal-on-metal total hip arthroplasty. Recently, late appearances of adverse reactions to metal debris and subsequent need for reoperations have been reported with small-diameter head metal-on-metal devices. We retrospectively investigated mid-term clinical outcomes of small-head metal-on-metal total hip arthroplasty. Methods: We reviewed 159 hips in 139 patients who had a small-head metal-on-metal total hip arthroplasty (M2a Taper; Biomet, Warsaw, IN) with a minimum 5-year follow-up and documented postoperative complications. Results: Focal osteolysis in either the femur or acetabulum was observed in 12 hips (7.5%, 44 months after surgery on average), with pseudotumor observed in 8 hips (5%, 120 months after surgery on average). Four hips (2.5%) had dislocations (84 months after surgery on average) and six hips (3.8%, 122 months after surgery on average) underwent reoperation. Conclusion: Small-head metal-on-metal total hip arthroplasty is associated with a high degree of complications at mid-term follow-up period. Considering this, we discourage the use of metal-on-metal total hip arthroplasty regardless of head size.


2013 ◽  
pp. 53-66
Author(s):  
Gulraj S. Matharu ◽  
Matthew P. Revell ◽  
Vaiyapuri Sumathi ◽  
Paul B. Pynsent ◽  
Peter A. Revell

2017 ◽  
Vol 99A (18) ◽  
pp. 1532-1539 ◽  
Author(s):  
Gulraj S. Matharu ◽  
Fiona Berryman ◽  
Andrew Judge ◽  
Aleksi Reito ◽  
Jamie McConnell ◽  
...  

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