scholarly journals Antineuronal antibodies and epilepsy: treat the patient, not the lab

2021 ◽  
pp. jnnp-2020-325350
Author(s):  
Stephan Rüegg
2016 ◽  
Vol 116 (02) ◽  
pp. 77-79
Author(s):  
A. K. Bayram ◽  
F. Kardas ◽  
E. O. Demirci ◽  
S. Gokahmetoglu ◽  
S. Ozmen ◽  
...  

1997 ◽  
Vol 41 ◽  
pp. 296-296
Author(s):  
H. S. Singer ◽  
J. D. Giuliano ◽  
B. Hansen ◽  
J. J. Hallett ◽  
J. J. Laurino ◽  
...  

2021 ◽  
Author(s):  
Wafa Abdelghaffar ◽  
Oussama Sidhom ◽  
Lilia Laadhar ◽  
Rym Rafrafi

The involvement of immunity in the pathogenesis of schizophrenia and related psychoses was suspected a century ago but was shadowed by the dopaminergic hypothesis after the discovery of antipsychotics. We currently know that this latter theory has many limits and cannot account for the wide variety of psychotic conditions. The immune-inflammatory theory is now one of the most promising axes of research in terms of pathogenesis of several mental health conditions. Immunity and inflammation play a role at least in a subgroup of patients with psychosis. The immune system is complex with a variety of components and mediators that can all have effects on the brain and thus mediate psychiatric symptoms. In this chapter we will explore the scientific evidence of the role of immune system in pathophysiology of psychosis. The sections of this chapter will discuss the role of innate system components (cytokines, microglia, inflammation.), the role of adaptive system (lymphocytes and antibodies) with a section focusing on auto-immunity and particularly antineuronal antibodies. Finally we will discuss how this research can impact patients management and elaborate recommendations for future research.


2012 ◽  
Vol 29 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Jainn-Jim Lin ◽  
Kuang-Lin Lin ◽  
Cheng-Hsun Chiu ◽  
Shao-Hsuan Hsia ◽  
Huei-Shyong Wang ◽  
...  

PEDIATRICS ◽  
1994 ◽  
Vol 93 (2) ◽  
pp. 323-326 ◽  
Author(s):  
Susan E. Swedo ◽  
Henrietta L. Leonard ◽  
Louise S. Kiessling

Several converging lines of evidence suggest that some behavioral and neurological abnormalities of childhood may be mediated through antineuronal antibodies.1-3 These antineuronal antibodies appear to arise in response to group A [beta]-hemolytic streptococcal (GABHS) infections and to cross-react with cells within the central nervous system (CNS).4 Based on clinical observations of children with Sydenham's chorea, Tourette's syndrome (TS), and/or obsessive-compulsive disorder (OCD), we hypothesize that neuroimmunological dysfunction secondary to anti-neuronal antibodies may result in behavioral disturbances, such as anxiety, emotional lability, obsessive compulsive symptoms, hyperactivity, and sleep disturbances; and neurological abnormalities, such as motor and phonic tics, ballismus, chorea, and choreiform movements.


2021 ◽  
pp. 203-213
Author(s):  
Johann Steiner ◽  
Winfried Stoecker ◽  
Bianca Teegen ◽  
Henrik Dobrowolny ◽  
Gabriela Meyer-Lotz ◽  
...  

2019 ◽  
pp. 320-323
Author(s):  
Peter Novak

Small fiber neuropathy, mixed, length-dependent can be autoimmune even if no antineuronal antibodies can be found. Yet the seronegative small fiber neuropathy may still respond to therapy with immune globulins.


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