scholarly journals Options for Screening for Colorectal Cancer in the Royal Air Force: A Cost-effectiveness Evaluation

1995 ◽  
Vol 141 (3) ◽  
pp. 142-150 ◽  
Author(s):  
K. Daniels ◽  
M. McKee
1996 ◽  
Author(s):  
Bradford D. Gessner ◽  
Steven M. Teutsch ◽  
Phaedra A. Shaffer

2020 ◽  
Author(s):  
Syeda Noor-ul-Huda Shahid ◽  
Usman W. Chohan
Keyword(s):  

1982 ◽  
Vol 12 (4) ◽  
pp. 289-301
Author(s):  
Ronnie Leung-Nee Tong ◽  
John D. Keenan

Author(s):  
Deborah A. Fisher ◽  
Jordan J. Karlitz ◽  
Sushanth Jeyakumar ◽  
Nathaniel Smith ◽  
Paul Limburg ◽  
...  

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Chun-Yi Lu ◽  
Ching-Hu Chung ◽  
Li-Min Huang ◽  
Eliza Kruger ◽  
Seng-Chuen Tan ◽  
...  

An amendment to this paper has been published and can be accessed via the original article.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kiyoaki Sugiura ◽  
Yuki Seo ◽  
Takayuki Takahashi ◽  
Hideyuki Tokura ◽  
Yasuhiro Ito ◽  
...  

Abstract Background TAS-102 plus bevacizumab is an anticipated combination regimen for patients who have metastatic colorectal cancer. However, evidence supporting its use for this indication is limited. We compared the cost-effectiveness of TAS-102 plus bevacizumab combination therapy with TAS-102 monotherapy for patients with chemorefractory metastatic colorectal cancer. Method Markov decision modeling using treatment costs, disease-free survival, and overall survival was performed to examine the cost-effectiveness of TAS-102 plus bevacizumab combination therapy and TAS-102 monotherapy. The Japanese health care payer’s perspective was adopted. The outcomes were modeled on the basis of published literature. The incremental cost-effectiveness ratio (ICER) between the two treatment regimens was the primary outcome. Sensitivity analysis was performed and the effect of uncertainty on the model parameters were investigated. Results TAS-102 plus bevacizumab had an ICER of $21,534 per quality-adjusted life-year (QALY) gained compared with TAS-102 monotherapy. Sensitivity analysis demonstrated that TAS-102 monotherapy was more cost-effective than TAS-102 and bevacizumab combination therapy at a willingness-to-pay of under $50,000 per QALY gained. Conclusions TAS-102 and bevacizumab combination therapy is a cost-effective option for patients who have metastatic colorectal cancer in the Japanese health care system.


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