scholarly journals Prevalence of Mycoplasma genitalium in different population groups: systematic review andmeta-analysis

2018 ◽  
Vol 94 (4) ◽  
pp. 255-262 ◽  
Author(s):  
Lukas Baumann ◽  
Manuel Cina ◽  
Dianne Egli-Gany ◽  
Myrofora Goutaki ◽  
Florian S Halbeisen ◽  
...  
Keyword(s):  
Systematic Review ◽  
General Population ◽  
Pregnant Women ◽  
Sex Workers ◽  
Meta Analysis ◽  
Mycoplasma Genitalium ◽  
Asymptomatic Patients ◽  
Prevalence Estimates ◽  
Study Heterogeneity ◽  
Sex With Men

BackgroundMycoplasma genitalium is a common cause of non-gonococcal non-chlamydial urethritis and cervicitis. Testing of asymptomatic populations has been proposed, but prevalence in asymptomatic populations is not well established. We aimed to estimate the prevalence of M. genitalium in the general population, pregnant women, men who have sex with men (MSM), commercial sex workers (CSWs) and clinic-based samples,MethodsWe searched Embase, Medline, IndMED, African Index Medicus and LILACS from 1 January 1991 to 12 July 2016 without language restrictions. We included studies with 500 participants or more. Two reviewers independently screened and selected studies and extracted data. We examined forest plots and conducted random-effects meta-analysis to estimate prevalence, if appropriate. Between-study heterogeneity was examined using the I2 statistic and meta-regression.ResultsOf 3316 screened records, 63 were included. In randomly selected samples from the general population, the summary prevalence was 1.3% (95% CI 1.0% to 1.8%, I2 41.5%, three studies, 9091 people) in countries with higher levels of development and 3.9% (95% CI 2.2 to 6.7, I2 89.2%, three studies, 3809 people) in countries with lower levels. Prevalence was similar in women and men (P=0.47). In clinic based samples, prevalence estimates were higher, except in asymptomatic patients (0.8%, 95% CI 0.4 to 1.4, I2 0.0%, three studies, 2889 people). Summary prevalence estimates were, in the following groups: pregnant women 0.9% (95% CI 0.6% to 1.4%, I2 0%, four studies, 3472 people), MSM in the community 3.2% (95% CI 2.1 to 5.1, I2 78.3%, five studies, 3012 people) and female CSWs in the community 15.9% (95% CI 13.5 to 18.9, I2 79.9%, four studies, 4006 people).DiscussionThis systematic review can inform testing guidelines for M. genitalium. The low estimated prevalence of M. genitalium in the general population, pregnant women and asymptomatic attenders at clinics does not support expansion of testing to these groups.Registration numbersPROSPERO: CRD42015020420

scholarly journals Prevalence ofMycoplasma genitaliumin different population groups: systematic review and meta-analysis

2017 ◽  
Author(s):  
Lukas Baumann ◽  
Manuel Cina ◽  
Dianne Egli-Gany ◽  
Myrofora Goutaki ◽  
Florian Halbeisen ◽  
...  
Keyword(s):  
Systematic Review ◽  
General Population ◽  
Pregnant Women ◽  
Sex Workers ◽  
Meta Analysis ◽  
Mycoplasma Genitalium ◽  
Asymptomatic Patients ◽  
Prevalence Estimates ◽  
Study Heterogeneity ◽  
Sex With Men

AbstractBackgroundMycoplasma genitaliumis a common cause of non-gonococcal non-chlamydial urethritis and cervicitis. Testing of asymptomatic populations has been proposed, but prevalence rates in asymptomatic populations are not well established. We aimed to estimate the prevalence ofM. genitaliumin adults in the general population, in clinic-based samples, pregnant women, men who have sex with men (MSM) and female sex workers (FSW).MethodsWe searched Embase, Medline, IndMED, AIM and LILACS from 1 January 1991 to 12 July 2016 without language restrictions. We included studies with 500 participants or more. We screened and selected studies and extracted data in duplicate. We examined eligible studies in forest plots and conducted random effects meta-analysis to estimate prevalence, if appropriate. Between study heterogeneity was examined using the I2statistic and meta-regression.ResultsOf 3,316 screened records, 63 were included. In randomly selected samples from the general population, the summary prevalence estimate was 1.3% (95% confidence intervals, CI 1.0 to 1.8%, I241.5%, 3 studies) in countries with higher levels of development and 3.9% (95% CI 2.2 to 6.7, I289.2%, 3 studies) in countries with lower levels. Prevalence estimates were similar in women and men (p=0.47). In clinic-based samples prevalence estimates were higher, except in asymptomatic patients (0.8%, 95% CI 0.4 to 1.4, I20.0%, 3 studies). Summary prevalence estimates were: pregnant women 0.9% (95% CI 0.6 to 1.4%, I20%, 4 studies); MSM in the community 3.2% (95% CI 2.1 to 5.1, I278.3%, 5 studies); FSW in the community 15.9% (95% CI 13.5 to 18.9, I2=79.9%, 4 studies).DiscussionThis systematic review can inform testing guidelines forM. genitaliuminfection. The low estimated prevalence ofM. genitaliumin the general population, pregnant women and asymptomatic attenders at clinics does not support expansion of testing to asymptomatic people in these groups.Registration NumbersPROSPERO: CRD42015020420

Prevalence of Mycoplasma genitalium by anatomical site in men who have sex with men: a systematic review and meta-analysis

2020 ◽  
Vol 96 (8) ◽  
pp. 563-570
Author(s):  
Rosie L Latimer ◽  
Hannah S Shilling ◽  
Lenka A Vodstrcil ◽  
Dorothy A Machalek ◽  
Christopher K Fairley ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Mycoplasma Genitalium ◽  
Nucleic Acid Amplification ◽  
Hiv Positive ◽  
Published Data ◽  
Anatomical Site ◽  
Ovid Medline ◽  
Registration Number ◽  
Sex With Men

ObjectiveTo systematically review and appraise published data, to determine the prevalence of Mycoplasma genitalium (MG) in men who have sex with men (MSM) tested at each anatomical site, that is, at the urethra, rectum and/or pharynx.DesignSystematic review and meta-analysis.Data sourcesOvid Medline, PubMed, Embase were searched for articles from 1st January 1981 (the year MG was first identified) to 1st June 2018.Review methodsStudies were eligible for inclusion if they reported MG prevalence in MSM tested at the urethra, rectum and/or pharynx, in at least 50 MSM, using nucleic acid amplification testing. Data were extracted by anatomical site, symptom and HIV status. Summary estimates (95% CIs) were calculated using random-effects meta-analysis. Subgroup analyses were performed to assess heterogeneity between studies.ResultsForty-six studies met inclusion criteria, with 34 reporting estimates of MG prevalence at the urethra (13 753 samples), 25 at the rectum (8629 samples) and 7 at the pharynx (1871 samples). MG prevalence was 5.0% (95% CI 3.5 to 6.8; I2=94.0) at the urethra; 6.2% (95% CI 4.6 to 8.1; I2=88.1) at the rectum and 1.0% (95% CI 0.0 to 5.1; I2=96.0) at the pharynx. The prevalence of MG was significantly higher at urethral and rectal sites in symptomatic versus asymptomatic MSM (7.1% vs 2.2%, p<0.001; and 16.1% vs 7.5%, p=0.039, respectively). MG prevalence at the urethra was significantly higher in HIV-positive compared with HIV-negative MSM (7.0% vs 3.4%, p=0.006).ConclusionMG was common in MSM, particularly at urethral and rectal sites (5% to 6%). MG was more commonly detected in symptomatic men at both sites, and more common in HIV-positive men at the urethra. MG was uncommonly detected in the pharynx. Site-specific estimates are similar to those for chlamydia and will be helpful in informing testing practices in MSM.PROSPERO registration numberCRD42017058326.

scholarly journals Prevalence of chronic kidney disease in the general population in Latin America and the Caribbean: Protocol for a systematic review and meta-analysis

2021 ◽  
Author(s):  
Diego A Sequeiros-Buendia ◽  
Camila S Villa-Ato ◽  
Marlies Weiss-Carlini ◽  
Rodrigo M Carrillo-Larco
Keyword(s):  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Latin America ◽  
Kidney Disease ◽  
General Population ◽  
Global Health ◽  
Meta Analysis ◽  
Prevalence Studies ◽  
Prevalence Estimates ◽  
The Caribbean

ABSTRACTBackgroundChronic kidney disease (CKD) is a global health issue with a general prevalence of 9%. Although the most affected populations are in low- and middle-income countries, the epidemiology of CKD in these countries remains poorly understood and prevalence estimates come from global efforts informed by data from high-income countries; these prevalence estimates need to be compared –and if needed updated–with local estimates.ObjectiveTo estimate the prevalence of CKD in adults in Latin America and the Caribbean (LAC).MethodsSystematic review and meta-analysis. We will search Embase, Medline, Global Health (these three through Ovid), Scopus and LILACS. No date or language restrictions will be set. We seek observational studies with a random sample of the general population. We will screen titles and abstracts, we will then study the selected reports. Both phases will be done by two reviewers independently. Data extraction will be performed by two researchers independently using a pre-specified Excel form. We will evaluate the risk of bias with the scale proposed by Hoy et al. for prevalence studies. We will conduct a meta-analysis of prevalence estimates, if there are at least three reports homogeneous enough to be pooled; we will use a random-effects model.ConclusionsThis systematic review and meta-analysis will provide the prevalence of CKD in adults in countries of LAC. Currently, information regarding CKD in the region is limited. This work will provide evidence to elucidate the magnitude of CKD prevalence in LAC. In so doing, we will provide evidence to inform the scientific community about the burden of CKD in LAC so that research, policies and health interventions can be planned accordingly.

scholarly journals HIV prevalence among female sex workers, drug users and men who have sex with men in Brazil: A Systematic Review and Meta-analysis

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Monica Malta ◽  
Monica MF Magnanini ◽  
Maeve B Mello ◽  
Ana Roberta P Pascom ◽  
Yohana Linhares ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sex Workers ◽  
Drug Users ◽  
Female Sex Workers ◽  
Meta Analysis ◽  
Hiv Prevalence ◽  
Female Sex ◽  
Sex With Men

scholarly journals Prevalence of schistosomiasis and its association with anemia among pregnant women: a systematic review and meta-analysis

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Ishag Adam ◽  
Nadiah A. ALhabardi ◽  
Osama Al-Wutayd ◽  
Ammar H. Khamis
Keyword(s):  
Systematic Review ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Perinatal Outcomes ◽  
Prevalence Estimate ◽  
Pooled Prevalence ◽  
Significant Difference ◽  
Prevalence Estimates ◽  
Newcastle Ottawa Scale ◽  
Meta Analyses

Abstract Background Schistosomiasis is a highly prevalent parasitic disease that can lead to adverse maternal and perinatal outcomes. To our knowledge, there has been no systematic review and meta-analysis of schistosomiasis during pregnancy. Methods We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant published studies were searched in international databases (PubMed, Science Direct, Scopus, Web of Science, and Google Scholar), from their inception until May 31, 2020. The retrieved studies were assessed for quality using the Modified Newcastle-Ottawa Scale. OpenMeta Analyst software was used for the statistical analysis. Results Thirty-two studies enrolling 21024 pregnant women were included in this meta-analysis. All 32 of these studies were conducted in Africa. Of these studies, 19, 11, and 2 investigated S. mansoni, S. haematobium, and combined S. mansoni and S. haematobium infections, respectively. The pooled prevalence estimate of schistosomiasis during pregnancy was 13.2% (95 CI 11.0–15.4). A random model was used because of high heterogeneity (Q = 99.14; P < 0.001). In subgroup analyses, the pooled prevalence estimate of S. haematobium was significantly higher than the pooled prevalence estimates of S. mansoni [22.5% (95% CI 1.6–43.5) vs 8.7% (95% CI 6.0–11.3, P = 0.016), respectively]. The results of meta-regression analyses showed a non-significant difference in the prevalence of schistosomiasis during pregnancy according to the study sample sizes and year of publication. Only six studies evaluated the association between schistosomiasis during pregnancy and anemia. Schistosomiasis was associated with anemia in these six studies (OR = 3.02, 95% = 1.25‒7.28, P = 0.014). Conclusion The present meta-analysis suggests that schistosomiasis during pregnancy is an existing health problem. This meta-analysis also highlights the lack of data on the determinants and outcomes of schistosomiasis during pregnancy. Preventive measures are needed and could be part of antenatal care in areas endemic with schistosomiasis.

scholarly journals Prevalence estimates of mental health problems in children and adolescents with intellectual disability: A systematic review and meta-analysis

2020 ◽  
Vol 54 (10) ◽  
pp. 970-984 ◽  
Author(s):  
Nicholas Buckley ◽  
Emma J Glasson ◽  
Wai Chen ◽  
Amy Epstein ◽  
Helen Leonard ◽  
...  
Keyword(s):  
Mental Health ◽  
Systematic Review ◽  
Intellectual Disability ◽  
General Population ◽  
Confidence Interval ◽  
Children And Adolescents ◽  
Meta Analysis ◽  
Pooled Prevalence ◽  
Prevalence Estimates ◽  
Developmental Behaviour Checklist

Background: Children and adolescents with intellectual disability are at risk of developing psychiatric symptoms and disorders; yet, the estimates reported in the literature have been inconsistent, presenting a potential barrier for service planning and delivery. Sources of variability could arise from differences in measurement instruments as well as subgroup membership by severity of intellectual disability, gender and age. This systematic review aimed to address these gaps. Method: MEDLINE and PsycINFO databases were searched from inception to 2018 and selected studies were reviewed. Studies were included if they reported point prevalence estimates of mental health symptomology or diagnoses in a general population of 6- to 21-year-old individuals with intellectual disability. The Joanna Briggs Institute Prevalence Critical Appraisal Checklist was applied to eligible papers to appraise their scientific strength. Pooled prevalence for mental health symptomology was determined using a random-effects meta-analysis. Results: A total of 19 studies were included, including 6151 children and adolescents. The pooled prevalence estimate captured by the Developmental Behaviour Checklist was 38% (95% confidence interval = [31, 46]), contrasting with 49% (95% confidence interval = [46, 51]) captured by the Child Behaviour Checklist; both rates were higher than a non-intellectual disability population. Severity of intellectual disability did not significantly influence the Developmental Behaviour Checklist risks. Insufficient data were available to conduct statistical analyses on the effects of age, gender and socioeconomic status. Of diagnosed psychiatric disorders, attention deficit/hyperactivity disorder (30%), conduct disorder (3–21%) and anxiety disorders (7–34%) were the most prevalent conditions. Conclusion: This review consists of the largest sample hitherto evaluated. In the intellectual disability population, mental health comorbidities could be better detected by a symptom phenotype than a psychiatric diagnostic phenotype. Crucially, future research needs to address the effect of measurement validity in the intellectual disability population. Estimated prevalence rates were high compared to the general population, indicating the importance of systematic screening, case detection and appropriate management.

scholarly journals Reported prevalence of suicidal ideation and suicide attempts among men who have sex with men in China: A systematic review and meta-analysis

2019 ◽  
Author(s):  
Hanlin Fu ◽  
Tubao Yang ◽  
Xiaobing Wu ◽  
Yumao Cai ◽  
tiejian feng
Keyword(s):  
Systematic Review ◽  
Suicidal Ideation ◽  
Suicide Attempts ◽  
Meta Analysis ◽  
Exclusion Criterion ◽  
Significant Heterogeneity ◽  
Pooled Prevalence ◽  
Prevalence Estimates ◽  
Sex With Men ◽  
Meta Analyses

Abstract Background: Men who have sex with men(MSM) in China are at high risk for suicidality but often overlooked. Several studies have reported the prevalence of suicidal ideation and suicide attempts. However, the estimates varies substantially between studies. This systematic review aimed to establish pooled prevalence of suicidal ideation and suicide attempts among MSM in China, in order to arouse the attention of the public.Methods: The relevant studies up to April 2019 were systematically searched via several electronic databases. Studies were screened according to inclusion and exclusion criterion and the random-effects meta-analyses were adopted to calculate the pooled prevalence estimates of suicidal ideation and suicide attempts. Heterogeneity between studies and publication bias was also assessed.Results: A total of 23 articles were eligible for the meta-analysis. The pooled prevalence estimate of suicidal ideation and suicide attempts was 20.1% (95%CI: 16.7%-23.7%) and 6.8%(95%CI: 5.0%-8.9%), respectively. Significant heterogeneity was found for both combined effects. Heterogeneity in the estimates could be partially explained by survey points, HIV infection and average age.Conclusions: The prevalence of suicidal ideation and suicide attempts among MSM in China was moderate high, suggesting that more attention should be paid to the subgroup and effective psychological interventions need to be established and implemented to reduce the suicide-related problems among Chinese MSM.

Comparison of Perinatal Outcomes of Pregnant Women with SARS, MERS and COVID-19: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Pengming Sun ◽  
Hangjing Gao ◽  
Xiqi Huang ◽  
Huanrui Zheng ◽  
Hongning Cai ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Perinatal Outcomes
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