scholarly journals S2 Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide

2021 ◽  
Author(s):  
S Couillard ◽  
A Laugerud ◽  
M Jabeen ◽  
S Ramakrishnan ◽  
J Melhorn ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Exhaled Nitric Oxide ◽  
Asthma Attack ◽  
Blood Eosinophils ◽  
Risk Scale

scholarly journals Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2021-217325
Author(s):  
Simon Couillard ◽  
Annette Laugerud ◽  
Maisha Jabeen ◽  
Sanjay Ramakrishnan ◽  
James Melhorn ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Asthma Management ◽  
Exhaled Nitric Oxide ◽  
Blood Eosinophil ◽  
The Novel ◽  
Asthma Attack ◽  
Patient Groups ◽  
Rate Ratios ◽  
Blood Eosinophils ◽  
Risk Scale

Reduction of the risk of asthma attacks is a major goal of current asthma management. We propose to derive a risk scale predicting asthma attacks based on the blood eosinophil count and exhaled nitric oxide. Biomarker-stratified trial-level attack rates were extracted and pooled from the control arms of the Novel START, CAPTAIN, QUEST, Benralizumab Phase 2b, PATHWAY, STRATOS 1–2 and DREAM trials (n=3051). These were used to derive rate ratios and the predicted asthma attack rate for different patient groups. The resultant prototype risk scale shows potential to predict asthma attacks, which may be prevented by anti-inflammatory treatment.

scholarly journals Clinical utility of fractional exhaled nitric oxide and blood eosinophils counts in the diagnosis of asthma-COPD overlap

2018 ◽  
Vol Volume 13 ◽  
pp. 2525-2532 ◽  
Author(s):  
Yusuke Takayama ◽  
Hiroshi Ohnishi ◽  
Fumiya Ogasawara ◽  
Kosuke Oyama ◽  
Tetsuya Kubota ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Clinical Utility ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide ◽  
Blood Eosinophils

scholarly journals Targeting dynamic hyperinflation in moderate to severe asthma – a randomised controlled trial

2021 ◽  
pp. 00738-2020
Author(s):  
A. N. van der Meer ◽  
K. de Jong ◽  
A. Hoekstra-Kuik ◽  
E. H. Bel ◽  
A. ten Brinke
Keyword(s):  
Nitric Oxide ◽  
Severe Asthma ◽  
Respiratory Health ◽  
Controlled Trial ◽  
Exhaled Nitric Oxide ◽  
Dynamic Hyperinflation ◽  
Small Airways ◽  
Asthma Patients ◽  
Anti Inflammatory ◽  
Blood Eosinophils

BackgroundDynamic hyperinflation (DH) is highly prevalent in moderate to severe asthma, which may significantly impede activities of daily life. We hypothesised that DH in asthma is due to inflammation of large and small airways and can be reduced by systemic anti-inflammatory treatment. Therefore, we investigated the effect of systemic glucocorticoids on DH in moderate to severe asthma patients and explored the relationships between inflammatory markers and changes in DH.MethodsIn this randomised placebo-controlled trial we included 32 asthma patients on inhaled glucocorticoid therapy showing DH, defined by a ≥10% reduction in inspiratory capacity measured by standardised metronome-paced tachypnea test. Patients received either triamcinolone (80 mg) or placebo intramuscularly. Before and 2 weeks after treatment, patients completed respiratory health questionnaires, had blood eosinophils and exhaled nitric oxide levels measured and underwent lung function and DH testing.ResultsAfter adjustment for potential confounders, DH was significantly reduced by 28.1% in the triamcinolone group, and increased by 9.4% in the placebo group (p=0.027). In the triamcinolone-treated patients, the reduction in DH was greater in patients with higher blood eosinophils at baseline (r=−0.592, p=0.020) and tended to be associated with a reduction in blood eosinophils (r=0.412, p=0.127) and exhaled nitric oxide (r=0.442, p=0.099).ConclusionsThis exploratory study suggests that dynamic hyperinflation in asthma can be reduced by systemic anti-inflammatory treatment, particularly in patients with elevated blood eosinophils. This supports the hypothesis that dynamic hyperinflation in asthma is due to airway inflammation and should be considered an important target for treatment.

Blood Eosinophils, Exhaled Nitric Oxide, And IgE Do Not Accurately Predict Sputum Eosinophils

2012 ◽  
Author(s):  
Annette T. Hastie ◽  
Wendy C. Moore ◽  
Huashi Li ◽  
Brian M. Rector ◽  
Rodolfo M. Pascual ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Exhaled Nitric Oxide ◽  
Sputum Eosinophils ◽  
Blood Eosinophils
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