Background:
Long non-coding RNA (LncRNAs), with the length over 200 nucleotides,
originate from intergenic, antisense, or promoter-proximal regions, is a large family of RNAs that
lack coding capacity. Emerging evidences illustrated that LncRNAs played significant roles in a
variety of cellular functions and biological processes in profuse human diseases, especially in
cancers. Cancer susceptibility candidate 9 (CASC9), as a member of the LncRNAs group, was firstly
found its oncogenic function in esophageal cancer. In following recent studies, a growing amount of
human malignancies are verified to be correlated with CASC9, most of which are derived from the
squamous epithelium tissue. This present review attempts to highlight the latest insights into the
expression, functional roles, and molecular mechanisms of CASC9 in different human malignancies.
Methods:
In this review, the latest findings related to the pathophysiological processes of CASC9
in human cancers were summarized and analyzed, the associated studies were collected in
systematically retrieval of PubMed used lncRNA and CASA9 as keywords.
Results:
CASC9 expression is identified to be aberrantly elevated in a variety of malignancies. The
over-expression of CASC9 has been suggested to accelerate cell proliferation, migration, cell growth
and drug resistance of cancer cells, while depress cell apoptosis, revealing its role as an oncogene.
Moreover, the current review demonstrated CASC9 closely relates to neoplastic transformation of
squamous epithelial cells and squamous metaplasia in non-squamous epithelial tissues. Finally, we
discuss the limitations and tremendous diagnostic/therapeutic potential of CASC9 in various human
cancers.
Results:
CASC9 expression is identified to be aberrantly elevated in a variety of malignancies. The
over-expression of CASC9 has been suggested to accelerate cell proliferation, migration, cell growth
and drug resistance of cancer cells, while depress cell apoptosis, revealing its role as an oncogene.
Moreover, the current review demonstrated CASC9 closely relates to neoplastic transformation of
squamous epithelial cells and squamous metaplasia in non-squamous epithelial tissues. Finally, we
discuss the limitations and tremendous diagnostic/therapeutic potential of CASC9 in various human
cancers.
Conclusion:
Long non-coding RNACASC9 likely served as useful disease biomarkers or therapy
targets that could effectively apply in treatment of different kinds of cancers.
Squamous metaplasia of the tracheal epithelium in children.