Influence of sex gap on muscle strength and functional mobility in patients with cystic fibrosis

2020 ◽  
Vol 45 (4) ◽  
pp. 387-392 ◽  
Author(s):  
María del M. Martínez-García ◽  
Juan J. Rodríguez-Juan ◽  
Juan D. Ruiz-Cárdenas
Keyword(s):  
Cystic Fibrosis ◽  
Muscle Strength ◽  
Lung Function ◽  
Muscle Weakness ◽  
Walking Speed ◽  
Handgrip Strength ◽  
Pancreatic Insufficiency ◽  
Functional Mobility ◽  
Healthy Controls ◽  
Sit To Stand

The objectives of this study were to determine whether there were differences in handgrip strength and functional mobility between patients with cystic fibrosis (CF) and healthy controls with regard to sex and to ascertain whether these differences were related to lung function. Thirty-eight patients with CF (21 women) and 38 healthy controls aged 18–65 years were included. Muscle weakness and functional mobility were assessed through handgrip strength; walking speed; and time, velocity, and power derived from a single sit-to-stand (STS) test. Patients with CF showed differences for STS variables and walking speed but not for handgrip strength, compared with healthy controls. Considering sex differences, female patients showed differences for all variables analyzed while males with CF only exhibited differences for STS variables, compared with healthy controls. Females with CF showed moderate relationship between muscle weakness, functional mobility, and lung function (|r| = 0.45–0.49; p ≤ 0.05) whereas no relationships were observed for males with CF. The influence of chronic infection with Pseudomonas aeruginosa and pancreatic insufficiency on muscle weakness and functional mobility was similar in both sexes. Differences in muscle strength and functional mobility were predominantly observed in females with CF. These results suggest an important effect of sex gap on muscle weakness and functional mobility in patients with CF. Novelty The influence of sex gap on muscle weakness in CF has been shown. Muscle weakness was predominantly observed in females with CF.

One-minute Sit-to-stand Test Is Practical to Assess and Follow the Muscle Weakness in Cystic Fibrosis.

2021 ◽  
Author(s):  
Sophie Hardy ◽  
Silvia Berardis ◽  
Anne-Sophie Aubriot ◽  
Gregory Reychler ◽  
Sophie Gohy
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Exercise Capacity ◽  
Muscle Weakness ◽  
Quadriceps Strength ◽  
Voluntary Contraction ◽  
Positive Trend ◽  
Stand Test ◽  
Sit To Stand ◽  
The Impact

Abstract Background: Quadriceps muscle weakness and reduced exercise tolerance are prevalent in patients with cystic fibrosis (CF) and associated with a worse prognosis. The one-minute sit-to-stand test (1STST) has been proposed to evaluate exercise capacity and assess quadriceps strength. The aim of the study was to correlate the 1STST and the maximal isometric voluntary contraction of the quadriceps (MVCQ) evaluated by the dynamometer in stable patients with CF and to evaluate the impact of intravenous (IV) antibiotherapy.Methods: MVCQ and exercise capacity (dynamometer and 1STST) were measured in stable patients with CF at a routine visit, at the admission and the discharge of an IV antibiotherapy. Patients wore an activity monitor during 72h during IV treatment. Results: 51 stable patients with CF at a routine visit and 30 treated with IV antibiotherapy were recruited. In stable patients, the number of repetitions was reduced to 2101nxkg±657 (mean±SD), representing 79% of the predicted values (%PV) (7;142) (median (min;max)) as well as the MVCQ to 78.64N-m (23.21;170.34), representing 57%PV±26. The 1STST was correlated to MVCQ (r=0.536;p<0.0001) and lung function (r=0.508;p=0.0001). Over the IV antibiotherapy course, the 1STST improves significantly like lung function and body mass index while a positive trend for MVCQ was observed. The gain of 1STST was correlated to the change in MVCQ (r=0.441;p=0.015) and was significantly higher in hospitalized patients versus home therapy.Conclusions: The 1STST is a good alternative to the dynamometer to evaluate and assess muscular weakness for the routine visit and IV antibiotherapy.

Peripheral muscle strength is associated with lung function and functional capacity in patients with cystic fibrosis

2019 ◽  
Vol 24 (3) ◽  
Author(s):  
Paula Maria Eidt Rovedder ◽  
Gabrielle Costa Borba ◽  
Mariluce Anderle ◽  
Josani Flores ◽  
Bruna Ziegler ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Muscle Strength ◽  
Lung Function ◽  
Functional Capacity ◽  
Peripheral Muscle

Respiratory mechanics in supine subjects during progressive partial curarization

1982 ◽  
Vol 52 (1) ◽  
pp. 57-63 ◽  
Author(s):  
T. J. Gal ◽  
N. S. Arora
Keyword(s):  
Muscle Strength ◽  
Muscle Weakness ◽  
Respiratory Mechanics ◽  
Handgrip Strength ◽  
Elastic Recoil ◽  
Lung Inflation ◽  
Progressive Muscle Weakness ◽  
Inspiratory Resistance ◽  
Residual Capacity ◽  
Partial Curarization

Respiratory mechanics were studied in six supine conscious volunteers during progressive muscle weakness produced by infusion of d-tubocurarine. Partial curarization was carried out to the point of abolishing head lift ability and handgrip strength. At all levels of partial paralysis, expiratory muscle strength was significantly more impaired than inspiratory strength. Despite this, subjects maintained relatively normal maximal expiratory flow rates, whereas inspiratory flows decreased significantly. The diminished inspiratory flows are not fully explained by decreased driving pressures during force inspiration, since inspiratory resistance increased significantly with the decreased flow. Inspiratory flow patterns suggest a variable extrathoracic obstruction most likely due to the absence of normal airway abductor activity during inspiration. Maximal respiratory muscle weakness decreased forced vital capacity by 29% and total lung capacity by 15%. The decreased level of lung inflation did not alter lung elastic recoil. Functional residual capacity was unchanged, but inspiratory capacity decreased by 25% and residual volume increased by 38%. These changes are in accord with predictions based on the decreased muscle strength and normal respiratory system recoil.

Corticosteroids and skeletal muscle function in cystic fibrosis

2003 ◽  
Vol 95 (4) ◽  
pp. 1379-1384 ◽  
Author(s):  
Sinead C. Barry ◽  
Charles G. Gallagher
Keyword(s):  
Skeletal Muscle ◽  
Cystic Fibrosis ◽  
Muscle Strength ◽  
Muscle Weakness ◽  
Muscle Function ◽  
Knee Extensor ◽  
Skeletal Muscle Function ◽  
Peripheral Muscle ◽  
Causative Effect ◽  
Concomitant Medications

Patients with cystic fibrosis (CF) have reduced peripheral muscle strength. We tested the hypothesis that steroid treatment contributes to muscle weakness in adults with CF. Twenty-three stable CF patients were studied. Measurements included knee extensor (KE), knee flexor (KF), elbow flexor (EF), handgrip (HG), expiratory (Pemax), and inspiratory (Pimax) muscle strengths. Spirometry, body mass index (BMI), and days spent in hospital over the preceding 12 mo (DH) were also measured. Average daily dose of prednisolone over the preceding 12 mo (ADD) was 5.1 mg/day. Pearson's correlation analysis revealed that ADD correlated significantly with skeletal muscle strengths (KF%, r = -0.63, P < 0.01) with the exception of HG%. These findings are independent of age, BMI, pulmonary function, and DH. Multiple-regression analysis revealed that ADD was the most significant predictor of all measures of skeletal muscle function except HG%. It was independently responsible for 54% of the variance in Pimax%, for 46% of the variance in Pemax%, for 45% of the variance in KE%, for 39% of the variance in KF%, and for 41% of the variance in EF%. Concomitant medications (e.g., theophylline) were shown to have no causative effect. Corticosteroids contribute to the skeletal muscle weakness seen in CF patients. The correlation of proximal muscle strength, but not HG strength, with steroid dosage further supports a cause-effect relationship.

scholarly journals Lung function over the life course of paediatric and adult patients with cystic fibrosis from a large multi-centre registry

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Arul Earnest ◽  
Farhad Salimi ◽  
Claire E. Wainwright ◽  
Scott C. Bell ◽  
Rasa Ruseckaite ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Pancreatic Insufficiency ◽  
Forced Expiratory Volume ◽  
Rate Of Change ◽  
Data Registry ◽  
Mortality Outcome ◽  
The Impact

Abstract A key measure of lung function in people with Cystic Fibrosis (CF) is Forced Expiratory Volume in the first second FEV1 percent predicted (FEV1pp). This study aimed to address challenges in identifying predictors of FEV1pp, specifically dealing with non-linearity and the censoring effect of death. Data was obtained from a large multi-centre Australian Cystic Fibrosis Data Registry (ACFDR). A linear mixed model was used to study FEV1pp as the endpoint. There were 3655 patients (52.4% male) included in our study. Restricted cubic splines were used to fit the non-linear relationship between age of visit and FEV1pp. The following predictors were found to be significant in the multivariate model: age of patient at visit, BMI z-score, age interaction with lung transplantation, insulin dependent diabetes, cirrhosis/portal hypertension, pancreatic insufficiency, Pseudomonas aeruginosa infection and baseline variability in FEV1pp. Those with P. aeruginosa infection had a lower mean difference in FEV1pp of 4.7 units, p < 0.001 compared to those who did not have the infection. Joint modelling with mortality outcome did not materially affect our findings. These models will prove useful for to study the impact of CFTR modulator therapies on rate of change of lung function among patients with CF.

scholarly journals Physical Therapy and Rehabilitation Ideas for Inspiratory Muscle Training in Patients With Subacute Stroke

2021 ◽  
Vol 19 (4) ◽  
pp. 455-464
Author(s):  
Irma Ruslina Defi ◽  
◽  
Novitri Novitri ◽  
Ilin Nurina ◽  
◽  
...  
Keyword(s):  
Muscle Strength ◽  
Lung Function ◽  
Walking Speed ◽  
Intervention Group ◽  
Quadriceps Strength ◽  
Control Group ◽  
Muscle Training ◽  
Stroke Patients ◽  
Paretic Side ◽  
Subacute Stroke

Objectives: This study aimed to elucidate the outcome of an Inspiratory Muscle Training (IMT) rehabilitation intervention on the lung function, functional mobilization, balance, and peripheral muscle strength of the paretic side in patients with subacute stroke. Methods: This double-blind, randomized controlled trial study was conducted on patients with stable subacute stroke. For 8 weeks, the intervention group (n=16) received 40% intensity IMT while the control group (n=16) received 10% intensity IMT. We assessed the patients’ lung function (spirometer) before and after the intervention, as well as their pulmonary muscle strength (micro-respiratory pressure meter [RPM]), quadriceps strength (handheld dynamometer), grip strength (Jamar), walking speed (10-m walk test), balance (Berg Balance Scale [BBS]), and functional mobilization (sit-to-stand test). Results: There were significant differences between the intervention group and the control group after IMT for forced vital capacity (FVC)% (P<0.01; d=3.20), forced expiratory volume in the first second (FEV1)/FVC (P<0.001; d=2.55), FEV1% (P<0.001; d=5.10), walking speed (P<0.05; d=1.62), hand grip (P<0.001; d=2.45), quadriceps strength (P<0.001; d=4.18), functional mobilization (P<0.01; d=2.41), and maximal inspiratory mouth pressure (P<0.001; d=1.62), but no significant changes were seen in balance (P=0.304; d=0.57). Discussion: IMT improved lung function, functional mobilization, handgrip strength, and quadriceps strength on the paretic side of subacute stroke patients and is expected to improve functional status and allow the patient to participate in social activities. IMT exercise can be included in the rehabilitation program for subacute stroke patients.

scholarly journals Quantifying upper limb motor impairment in people with Parkinson’s disease: a physiological profiling approach

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10735
Author(s):  
Lewis A. Ingram ◽  
Vincent K. Carroll ◽  
Annie A. Butler ◽  
Matthew A. Brodie ◽  
Simon C. Gandevia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Muscle Strength ◽  
Upper Limb ◽  
Bimanual Coordination ◽  
Handgrip Strength ◽  
Position Sense ◽  
Healthy Controls ◽  
Limb Function ◽  
Upper Limb Function

Background Upper limb motor impairments, such as slowness of movement and difficulties executing sequential tasks, are common in people with Parkinson’s disease (PD). Objective To evaluate the validity of the upper limb Physiological Profile Assessment (PPA) as a standard clinical assessment battery in people with PD, by determining whether the tests, which encompass muscle strength, dexterity, arm stability, position sense, skin sensation and bimanual coordination can (a) distinguish people with PD from healthy controls, (b) detect differences in upper limb test domains between “off” and “on” anti-Parkinson medication states and (c) correlate with a validated measure of upper limb function. Methods Thirty-four participants with PD and 68 healthy controls completed the upper limb PPA tests within a single session. Results People with PD exhibited impaired performance across most test domains. Based on validity, reliability and feasibility, six tests (handgrip strength, finger-press reaction time, 9-hole peg test, bimanual pole test, arm stability, and shirt buttoning) were identified as key tests for the assessment of upper limb function in people with PD. Conclusions The upper limb PPA provides a valid, quick and simple means of quantifying specific upper limb impairments in people with PD. These findings indicate clinical assessments should prioritise tests of muscle strength, unilateral movement and dexterity, bimanual coordination, arm stability and functional tasks in people with PD as these domains are the most commonly and significantly impaired.

scholarly journals Sputum and plasma adiponectin levels in clinically stable adult cystic fibrosis patients with CFTR I1234V mutation

2019 ◽  
Author(s):  
Atqah AbdulWahab ◽  
Mona Allangawi ◽  
Merlin Thomas ◽  
Ilham Bettahi ◽  
Siveen K. Sivaraman ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Adiponectin Level ◽  
Pancreatic Insufficiency ◽  
Forced Expiratory Volume ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Plasma Adiponectin ◽  
Inflammatory Status ◽  
Significant Difference ◽  
The Mean

Abstract Background: Cystic fibrosis (CF) lung disease is associated with chronic inflammation leading to progress in lung function. Adiponectin is a predominantly anti-inflammatory adipokine that may have a role in CF lung. This study aims to determine total sputum and total plasma adiponectin levels in clinically stable adults CF patients with CFTR I1234V mutation, compared to plasma adiponectin levels in healthy controls and to investigate their correlations with body mass index (BMI) and spirometry in patients with CF. Methods: A cross-sectional study comprises 17 CF patients and 18 healthy controls. Adiponectin levels were measured by magnetic bead-based multiplex assay. Results: The mean age of adult CF patients was 22.9 years± 3.8 (18-30) and 76.5% CF patients had pancreatic sufficiency. The mean BMI in healthy controls was slightly higher than CF patients. The mean sputum adiponectin level was significantly lower than plasma adiponectin levels in CF patients and healthy controls (p<0.001), whereas no significant difference in plasma adiponectin levels between CF patients and healthy controls. The mean sputum adiponectin level was observed to be higher in CF patients with pancreatic insufficiency. Sputum adiponectin level was correlated positively with plasma adiponectin level in CF patients (r= 0.47, p=0.06). Sputum and plasma adiponectin levels in CF patients were correlated negatively with BMI and percentage predicted forced expiratory volume in 1 second (FEV1) and Forced vital capacity (FVC). Conclusions: Sputum adiponectin may provide a minimally invasive tool in the assessment of an inflammatory status in CF patients. Further larger study to address any difference in sputum and plasma adiponectin levels among CF patients with pancreatic sufficiency versus pancreatic insufficiency.

Sign in / Sign up

Export Citation Format

Share Document