Genetic analysis of blood pressure in the Milan hypertensive strain of rat (Rattus norvegicus)

1986 ◽  
Vol 28 (6) ◽  
pp. 967-970 ◽  
Author(s):  
G. Schlager ◽  
B. R. Barber ◽  
G. Bianchi
Keyword(s):  
Blood Pressure ◽  
Rattus Norvegicus ◽  
Blood Pressure Level ◽  
Pressure Level ◽  
Normal Blood ◽  
Normal Blood Pressure ◽  
Genetic Determination ◽  
Genetic Cross ◽  
Blood Pressures ◽  
Hypertensive Strain

Estimates of heritability (h2) of blood pressure level and the number of loci controlling the trait were derived from two genetic crosses involving the Milan hypertensive strain of rat and its control with normal blood pressure. In the genetic cross involving backcrosses, the estimates were h2 = 64% and the number of loci was two or three; there was some evidence of dominance of the alleles for normal blood pressures. In the other cross with only F2's, the degree of genetic determination (heritability in the broad sense) was 45%, involving at least three loci.Key words: rat, blood pressure, models, quantitative inheritance.

THE FLUSH METHOD FOR DETERMINING BLOOD PRESSURES IN INFANTS

PEDIATRICS ◽  
1958 ◽  
Vol 21 (6) ◽  
pp. 950-957
Author(s):  
Arthur J. Moss ◽  
Wilbert Liebling ◽  
Forrest H. Adams
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Normal Blood ◽  
First Year ◽  
Pressure Measurements ◽  
Normal Blood Pressure ◽  
Chronic Infections ◽  
Arithmetic Means ◽  
Blood Pressures ◽  
The Mean

Observations were made on 551 Caucasian infants from 1 day to 1 year of age. All subjects had normal cardiovascular status and were free from acute or chronic infections. A total of 1,712 measurements of blood pressure were obtained by the flush technique. It is known that measurements made using the flush technique approximate the mean rather than the systolic blood pressure. The values obtained were analyzed in relation to sex, age and body weight. No correlation is found between sex and blood pressure or between body weight within a given monthly age category and blood pressure. Measurements of blood pressure show a pronounced and highly significance rise following the first week of life. During the first 9 months of life the readings are somewhat higher at the wrist than at the ankle. Thereafter, the converse is true. The significance of these findings is discussed. Arithmetic means and the range of normal blood pressure are presented. Exclusive of the first week of life, the range of normal blood pressure during the first year is from 51 to 93 mm Hg for the upper extremity and from 44 to 92 mm Hg for the lower extremity.

scholarly journals Interrelations between heart rate, hypertension, and the other cardiovascular risk factors in Krasnoyarsk Krai population

2019 ◽  
Vol 34 (3) ◽  
pp. 179-185
Author(s):  
V. V. Shabalin ◽  
Yu. I. Grinshtein ◽  
R. R. Ruf ◽  
A. Yu. Shtrikh
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Heart Rate ◽  
Representative Sample ◽  
Statistical Significance ◽  
Age Groups ◽  
Blood Pressure Level ◽  
Normal Blood ◽  
Krasnoyarsk Krai ◽  
Normal Blood Pressure

Aim. To evaluate the heart rate in the state of rest and to find its interrelations with gender, age, blood pressure level, estimated glomerular filtration rate, and metabolic syndrome components in the representative sample of Krasnoyarsk Krai population.Material and Methods. Within the framework of ESSE-RF study, the representative sample consisted of 1 411 Krasnoyarsk Krai inhabitants aged 25–64 with no history of beta-blocker intake. With IBM SPSS v. 22, we calculated the descriptive statistics and checked group disparities for statistical significance (significant at p≤0.05).Results. The median heart rate in the sample was 72 (66; 78) beats per minute. We found no significant disparities neither in gender (p = 0.182) nor in age groups (p = 0.084). The heart rate in hypertensive people (73 (68; 80) beats per minute) was significantly higher (p < 0.001) compared to those with normal blood pressure (71 (65; 76) beats per minute). Besides, the heart rate over 80 beats per minute was more prevalent in hypertension and prehypertension compared to normal blood pressure. Renal dysfunction was associated with a slight heart rate decrement, while hyperglycemia (blood glucose over 7 mmol/L), hyperuricemia, and obesity (both general and abdominal) were associated with increased heart rate. Dyslipidemia had no association with heart rate.Conclusion. In Krasnoyarsk Krai population, the heart rate significantly increased in people with hypertension, prehypertension, or at least one component of metabolic syndrome (hyperglycemia, obesity, or hyperuricemia). In patients with prehypertension and hypertension, the heart rate over 80 beats per minute was significantly more prevalent compared to people with normal blood pressure. 

scholarly journals MO1018IS LOW NORMAL BLOOD PRESSURE LEVEL IN PATIENTS WITH X-LINKED ALPORT SYNDROME OUR GOAL?

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Marina Aksenova ◽  
Konstantin Tutelman ◽  
Natalia Konkova
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Renal Disease ◽  
Alport Syndrome ◽  
Blood Pressure Level ◽  
Pressure Level ◽  
Male Gender ◽  
Mean Blood Pressure ◽  
Normal Blood Pressure ◽  
Independent Risk Factors

Abstract Background and Aims The mean blood pressure &lt;50th percentile for age, gender and height is recommended in children with chronic kidney disease, especially in case of proteinuria. The aim was to define the influence of low normal mean blood pressure level on the progression of renal disease in children with X-linked Alport syndrome (XLAS). Method mean day blood pressure normalized for sex, age, height (MBP), urine protein (mg/m2/day) and eGFR were assessed in retrospective single center study. Results The children with XLAS (n=69, 47M, age 9.49±4.18 years, eGFR=109±17.36 ml/min/1,73m2) were divided into 3 groups according the MBP level during follow up (4[3;5] years): (1) MBP&lt;50‰ (n=27, 13М), (2) MBP 50-90‰ (n=33, 25M), (3) MBP≥90‰ (9М). The decline of eGFR (ml/min/1,73m2/year) was higher in male (-3[-0.8;-4.7] vs 0.2[-0.4;2]; χ2= 21.15587, p = 0.0067), in children with MBP ≥90‰ (0.65[-2.65;2] vs -2.3[-6;2.3] vs -3[-7.5;-1.8] in 1st, 2nd and 3 groups, respectively; р1,3=0.0091) and in patients with proteinuria (-2.5[-7;0.5] vs 0.2[-4;3]; p=0.0018). The risk of achieving eGFR&lt;60 ml/min/1,73m2 was higher in pts of 3 group (OR=5.33, 95% CI 1.75;16.22) especially in the presence of proteinuria (OR=7.08, 95% CI 2.46;20.39). The multivariate analysis of predictive factors for eGFR reduction showed that the proteinuria (χ2=12.554, p=0.0019), the male gender (χ2=7.107, p=0.0077) and not MBP (χ2=5.4, p=0.07) were independent risk factors for eGFR decline. Conclusion The male gender and proteinuria are independent risk factors for renal disease progression in children with XLSA. We assumed that the goal of treatment, at least in XLAS’ patients with normal blood pressure, is to decrease proteinuria.

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