L'azote n'est pas le site basique des amides encombrés
Keyword(s):
The shift of the carbonyl band of the iodine complexes with the hindered amides i-PrCON(C6H11)2, t-BuCON(C6H11)2, and t-BuCON(i-Pr2) shows that the iodine interacts with the oxygen atom of the carbonyl group. Hydrogen bond donors, such as p-FC6H4OH, CHCl3, or CHBr3, also interact with the oxygen atom of the carbonyl group. The only differences between these hindered amides and unhindered amides like MeCONMe2 are the lower complexation constants (15 L mol−1 for MeCONMe2–I2 vs. 3 L mol−1 for t-BuCON(i-Pr2) and a lower stoichiometry of complexation (for example, a mixture of 1:1 and 1:2 complexes is obtained with t-BuCON(C6H11)2 while MeCONMe2 forms mainly 1:2 complexes).
1992 ◽
Vol 21
(12)
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pp. 1289-1289
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1984 ◽
pp. 309
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2008 ◽
Vol 2008
(35)
◽
pp. 5922-5927
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2016 ◽
Vol 12
◽
pp. 2834-2848
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Keyword(s):