Comparative study of the metabolic fate of selenate, selenite, and sulfate ions in cartilage

1969 ◽  
Vol 47 (7) ◽  
pp. 591-595 ◽  
Author(s):  
J. D. Cipera ◽  
M. Hidiroglou
Keyword(s):  
Comparative Study ◽  
The Other ◽  
Activity Levels ◽  
Metabolic Fate ◽  
Basic Difference ◽  
Sulfate Ions ◽  
Other Hand ◽  
Lipid Fractions ◽  
Metabolic Behavior

In vivo injections of three types of anions (75SeO3=, 75SeO4=, 35SO4=) into rabbits revealed a basic difference between the metabolic behavior of the selenium anions and that of sulfur anion in cartilage; whereas sulfate was incorporated predominantly into glycosaminoglycans, the entry of both selenium ions into this fraction was almost nonexistent. On the other hand, protein and lipid fractions isolated from cartilage had higher activity levels when selenium ions were injected than when sulfate was injected. In cartilage, the selenate activity disappeared at a faster rate than either selenite or sulfate. In blood sera the rate of activity disappearance was higher with both selenate and sulfate than with selenite.

Oxytocin analogues with non-coded amino acid residues in position 8: [8-Neopentylglycine]oxytocin and [8-cycloleucine]oxytocin

1987 ◽  
Vol 52 (9) ◽  
pp. 2317-2325 ◽  
Author(s):  
Jan Hlaváček ◽  
Jan Pospíšek ◽  
Jiřina Slaninová ◽  
Walter Y. Chan ◽  
Victor J. Hruby
Keyword(s):  
Amino Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
The Other ◽  
Amino Acid Residues ◽  
Phase Synthesis ◽  
Other Hand ◽  
Fragment Condensation

[8-Neopentylglycine]oxytocin (II) and [8-cycloleucine]oxytocin (III) were prepared by a combination of solid-phase synthesis and fragment condensation. Both analogues exhibited decreased uterotonic potency in vitro, each being about 15-30% that of oxytocin. Analogue II also displayed similarly decreased uterotonic potency in vivo and galactogogic potency. On the other hand, analogue III exhibited almost the same potency as oxytocin in the uterotonic assay in vivo and in the galactogogic assay.

In vitro insulin-mimetic activity and in vivo metallokinetic feature of oxovanadium(IV)porphyrin complexes in healthy rats

2012 ◽  
Vol 16 (01) ◽  
pp. 114-121 ◽  
Author(s):  
Tapan K. Saha ◽  
Yutaka Yoshikawa ◽  
Hirouki Yasui ◽  
Hiromu Sakurai
Keyword(s):  
The Other ◽  
Insulin Mimetic ◽  
Other Hand ◽  
Better Than

We prepared [meso-tetrakis(4-carboxylatophenyl)porphyrinato]oxovanadium(IV) tetrasodium, ([VO(tcpp)]Na4), and investigated its in vitro insulin-mimetic activity and in vivo metallokinetic feature in healthy rats. The results were compared with those of previously proposed insulin-mimetic oxovanadium(IV)porphyrin complexes and oxovanadium(IV) sulphate. The in vitro insulin-mimetic activity and bioavailability of [VO(tcpp)]Na4 were considerably better than those of [meso-tetrakis (1-methylpyridinium-4-yl)porphyrinato]oxovanadium(IV)(4+) tetraperchlorate ([VO(tmpyp)](ClO4)4) and oxovanadium(IV) sulphate. On the other hand, [VO(tcpp)]Na4 and [meso-tetrakis(4-sulfonatophenyl) porphyrinato]oxidovanadate(IV)(4-)([VO(tpps)]) showed very similar in vitro insulin-mimetic activity and in vivo metallokinetic feature in healthy rats. In particular, the order of in vitro insulin-mimetic activity of the complexes was determined to be: [VO(tcpp)]Na4 ≈ [VO(tpps)] > ([VO(tmpyp)](ClO4)4 > oxovanadium(IV) sulphate.

scholarly journals Seminal vesicle proteins SVS3 and SVS4 facilitate SVS2 effect on sperm capacitation

Reproduction ◽  
2016 ◽  
Vol 152 (4) ◽  
pp. 313-321 ◽  
Author(s):  
Naoya Araki ◽  
Natsuko Kawano ◽  
Woojin Kang ◽  
Kenji Miyado ◽  
Kaoru Yoshida ◽  
...  
Keyword(s):  
Seminal Vesicle ◽  
Reproductive Tract ◽  
Female Reproductive Tract ◽  
The Other ◽  
Sperm Capacitation ◽  
Other Hand ◽  
Sperm Membrane ◽  
Vesicle Secretion ◽  
Mammalian Spermatozoa

Mammalian spermatozoa acquire their fertilizing ability in the female reproductive tract (sperm capacitation). On the other hand, seminal vesicle secretion, which is a major component of seminal plasma, inhibits the initiation of sperm capacitation (capacitation inhibition) and reduces the fertility of the capacitated spermatozoa (decapacitation). There are seven major proteins involved in murine seminal vesicle secretion (SVS1-7), and we have previously shown that SVS2 acts as both a capacitation inhibitor and a decapacitation factor, and is indispensable forin vivofertilization. However, the effects of SVSs other than SVS2 on the sperm have not been elucidated. Since mouseSvs2–Svs6genes evolved by gene duplication belong to the same gene family, it is possible that SVSs other than SVS2 also have some effects on sperm capacitation. In this study, we examined the effects of SVS3 and SVS4 on sperm capacitation. Our results showed that both SVS3 and SVS4 are able to bind to spermatozoa, but SVS3 alone showed no effects on sperm capacitation. On the other hand, SVS4 acted as a capacitation inhibitor, although it did not show decapacitation abilities. Interestingly, SVS3 showed an affinity for SVS2 and it facilitated the effects of SVS2. Interaction of SVS2 and spermatozoa is mediated by the ganglioside GM1 in the sperm membrane; however, both SVS3 and SVS4 had weaker affinities for GM1 than SVS2. Therefore, we suggest that separate processes may cause capacitation inhibition and decapacitation, and SVS3 and SVS4 act on sperm capacitation cooperatively with SVS2.

scholarly journals Entrepreneurship in small and medium-sized enterprises: Comparative study between Slovakia and Poland for the years 2001–2007

2008 ◽  
Vol 54 (No. 8) ◽  
pp. 358-366 ◽  
Author(s):  
I. Ubrežiová ◽  
K. Wach ◽  
J. Horváthová
Keyword(s):  
Comparative Study ◽  
National Economy ◽  
Transition Economy ◽  
The Other ◽  
Regional Structure ◽  
Main Attention ◽  
Supporting System ◽  
Other Hand ◽  
The Impact

The main attention of the submitted paper is devoted to the comparison of development of entrepreneurship in Slovak and Polish small and medium-sized he enterprise sector. The conditions for blooming entrepreneurship are created in the national economy. Especially the role of SMEs in the transition economy, both in Slovakia and Poland, has the impact on SMEs. The entrepreneurship of small and medium-sized enterprises is extended in the whole Slovakia. From the viewpoint of the regional structure, most enterprises are located in the Bratislavský region (30.4%), Košický region (11.8%), Žilinský region (10.1%) and Trenčianský region (10.1%). On the other hand, the least of enterprises were registered in the Nitrianský region (8.9%), Trnavský region (9.2%) and Banskobystrický region (9.6%). Small and medium entrepreneurship is diversed throughout Poland. The average small and medium entreprenership ratio is 44.5, while the highest is in the Mazowieckie region – 55.2% and the lowest in the Podkarpackie region – 30 %. The supporting system for private entrepreneurship in both countries, Slovakia and Poland, is very similar and the entrepreneurs are satisfied with its offer and help.

The Influence of 17-Oxo- and 17-Hydroxy-16,17-secoestratriene Derivatives on Estrogen Receptor

2006 ◽  
Vol 71 (4) ◽  
pp. 532-542 ◽  
Author(s):  
Suzana Jovanović-Šanta ◽  
Julijana Petrović ◽  
Marija Sakač ◽  
Zorica Žakula ◽  
Esma Isenović ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptors ◽  
Estrogenic Activity ◽  
Total Loss ◽  
The Other ◽  
Binding Parameters ◽  
Antiestrogenic Activity ◽  
Other Hand

Since many of newly synthesised D-secoestratriene derivatives showed antiestrogenic effect, with almost a total loss of estrogenic activity, we studied the effects of some of these compounds on estrogen receptors (ER), the translocation of the estrogen-ER complexes formed in presence of competing substances into the nucleus, as well as the binding of these complexes to DNA. The results of uterotrophic effects of analysed derivatives are in agreement with the influence of these compounds on activity and binding parameters of estrogen receptors. Namely, compounds that show relatively high antiestrogenic activity predominantly increase Kd and inhibit translocation to nuclei of radioactive complexes formed in their presence. On the other hand, compounds that do not significantly change binding parameters of estrogen receptors do not show antiestrogenic effect in in vivo experiments.

A Comparative Study of Embelia Schiperi and Embelia Keniensis on Blood Glucose and Triglycerides in Normal and Epinephrine- Induced Hyperglycemic Mice

1999 ◽  
Vol 27 (03n04) ◽  
pp. 365-370
Author(s):  
Atsushi Kato ◽  
Toshihiro Miura ◽  
Yumi Nishiyama ◽  
Yoko Tachibana ◽  
Yasuhiro Ohnishi ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Comparative Study ◽  
Methanol Extract ◽  
Intraperitoneal Administration ◽  
The Other ◽  
Blood Cholesterol ◽  
Lipid Lowering ◽  
Other Hand ◽  
Lowering Activity

Intraperitoneal administration of the methanol extract of Embelia schiperi (ES) to normal mice caused a significant decrease in blood glucose (p < 0.01) and a significant increase in triglycerides 4 hours after administration at 100 mg/kg (p < 0.01). The toluene fraction of Embelia keniensis methanol extract (TS) showed hypoglycemic and lipid lowering activity 7 hours after intraperitoneal administration at 100 mg/kg. In addition, TS (100 mg/kg) administration significantly decreased blood glucose in epinephrine-induced hyperglycemic mice (p < 0.01). Moreover, ES tended to increase while TS tended to decrease the blood triglycerides in epinephrine-induced hyperglycemic mice. On the other hand, no changes in blood cholesterol were observed after the administration of ES or TS in normal and epinephrine-induced hyperglycemic mice. We found that two species from Embelia, ES and TS, have different activities on blood glucose and triglycerides in normal and epinephrine-induced hyperglycemic mice.

scholarly journals A comparative study of using formalin in fish of Tangail and Tongi town

2015 ◽  
Vol 21 ◽  
pp. 43-49
Author(s):  
Luthfunnesa Bari ◽  
M Ariful Islam ◽  
Zannatul Ferdous ◽  
M Atiqul Azman ◽  
Shahanaz Khatun ◽  
...  
Keyword(s):  
Comparative Study ◽  
Industrial Research ◽  
The Other ◽  
Other Hand ◽  
Fish Samples

Context: Recent reports of media have brought great attention to the problem of formalin used by whole sellers and venders in preserving fish. It is evident from several studies that fish items in different markets in Bangladesh are treated with formalin for preservation which is highly hazardous and carcinogenic chemical. Objectives: The study was undertaken to determine the presence of formalin in fishes collected from various wet markets of Tangail and Tongi town. Materials and Methods: From 12 selected wet markets, various species of fishes were collected and presence of formalin was detected using the “formalin detection kit in fish” developed by Bangladesh Council of Scientific and Industrial Research (BCSIR). Results: It was found that 16 fishes were formalin contaminated out of 192 fish samples in which 0% in Santosh bazar, 11.11% in Soi ani bazar, 13.33% in Park bazar, 14.81% in Old bus stand bazar, 0% in Chara bari bazar and 12.82% in New bus stand bazar of Tangail town. On the other hand, 33 formalin contaminated fish out of 171 were obtained in which 0% in Coto bazar, 20% in Gazipura bus stand bazar, 37.5% in Chourasta bazar, 0% in Boro bari bazar, 36.36% in CheragAli bazar and 20% in Tongi bazar of Tongi town. The study indicates that almost 8.33% of fish samples in Tangail town and 19.29% of fish samples in Tongi town were formalin contaminated. Conclusion: The present study revealed that in Tangail town 75% imported fish and 25% local fishes were formalin contaminated whereas in Tongi town, 82% imported fishes and 18% local fishes were formalin contaminated. DOI: http://dx.doi.org/10.3329/jbs.v21i0.22518 J. bio-sci. 21: 43-49, 2013

scholarly journals معايير التأثر والتأثير بين رواية زينب وفريدة هانم: دراسة مقارنة (The Criteria of Influence and Effect between the Novel of Zainab and Faridah Hanum: A Comparative Study)

1970 ◽  
Vol 2 (1) ◽  
Author(s):  
روسني بن سامة (Rosni Bin Samah)
Keyword(s):  
Comparative Study ◽  
The Other ◽  
Creative Work ◽  
The Novel ◽  
Other Hand ◽  
The Status ◽  
Literary Circles

ملخص البحث:تعد رواية فريدة هانم الماليزية أول رواية فنية في الأدب الماليزي الحديث، حيث اتفق الأدباء والباحثون على ذلك، ولكنهم اختلفوا في أصليتها الإبداعية لوجود تصوير البيئة المصرية لأحداثها. ومن جهة أخرى عاش البطل في الرواية من بدايتها حتى نهايتها في القاهرة، ومنهم من رأى بأنها رواية مترجمة من الرواية العربية، ومن منهم من رأى بأنها رواية إبداعية ابتدعها الراوي بتصوير البيئة المصرية. وتهدف هذه الدراسة إلى الكشف عن حقيقة أمرها بتجلية معايير تأثرها برواية زينب، حيث قام الباحث بالمقارنة بين الروايتين، وتوصلت النتائج إلى أن رواية فريدة هانم الماليزية تأثرت برواية زينب المصرية ولكن راويها لا يترجم تلك الرواية بل قام بالاطلاع عليها ثم صاغها بصياغته الجديدة مع رعاية البيئة المصرية وعاء لها.الكلمات المفتاحية: رواية هانم المصرية- رواي هانم الماليزية- معاير الرواية -المقارنة- التشابه.Abstract:Faridah Hanum is regarded as the first  Malay novel in Modern Malay Literature by the literary circles and researchers but they are in disagreement on the originality of its creativity features since its setting is Egyptian. On the other hand, its hero lived in Cairo from the beginning of the story until the end. Some of them viewed that it is a translated version of an Arabic novel while others still see it as a creative work with an Egyptian background. This study aims at discovering the truth about the status of the novel through pointing out the influences of the Arabic novel “Zainab” on it. This is done through comparing between the two novels. It is concluded that the Malay novel “Faridah Hanum” indeed had been influenced by “Zainab”, but it is not a translation but rather the writer happened to have read the Zainab novel but later on tried to put the story in  a new plot though he did retain the Egytian background as the setting.Keywords: Hanum Egyptian Novel–  Hanim the Malaysian novelist– Standards of Novel – Comparison– Similarities.Abstrak:Faridah Hanum dianggap sebagai novel Melayu pertama dalam kesusasteraan Melayu moden oleh kumpulan sasterawan dan penyelidik-penyelidik namun mereka masih lagi berada dalam percanggahan tentang keasliannya kerana persekitarannya yang berlatarkan sebuah negara asing: Mesir kerana wiranya tinggal di Kaherah dari permulaan cerita sehinggalah ke penghujungnya. Sebahagian dar mereka melihat yang ia adalah satu terjemahan satu novel Arab manakala yang lain masih menyaksikan ia adala satu hasil kerja kreatif dengan hanya menggunakan latar belakang Mesir. Kajian ini bertujuan untuk menemukan beberapa fakta tentang status novel tersebut dengan melihat kepada pengaruh-pengaruh novel Arab “Zainab”  yang terdapat padanya. Ini dilaksanakan melalui perbandingan antara dua novel tersebut. Kesimpulannya, novel Melayu “Faridah Hanum” sememangnya telah dipengaruhi oleh “Zainab”, namun ia bukan satu terjemahan tetapi penulis telah berpeluang  membaca novel Zainab dan kemudiannya cuba untuk meletakkan cerita dalam satu plot baru walaupun dia mengekalkan latar belakang Mesir sebagai persekitaran ceritanya.Kata kunci: Orang Mesir– Hanum– Hanim novelis Malaysia– Piawaian Novel– Persamaan-persamaan– Perbandingan.

scholarly journals Interplay between MPIase, YidC, and PMF during Sec-independent insertion of membrane proteins

2021 ◽  
Vol 5 (1) ◽  
pp. e202101162
Author(s):  
Yuta Endo ◽  
Yuko Shimizu ◽  
Hanako Nishikawa ◽  
Katsuhiro Sawasato ◽  
Ken-ichi Nishiyama
Keyword(s):  
Membrane Proteins ◽  
Molecular Basis ◽  
Terminal Region ◽  
Integral Membrane Proteins ◽  
The Other ◽  
Other Hand ◽  
Model Protein

Integral membrane proteins with the N-out topology are inserted into membranes usually in YidC- and PMF-dependent manners. The molecular basis of the various dependencies on insertion factors is not fully understood. A model protein, Pf3-Lep, is inserted independently of both YidC and PMF, whereas the V15D mutant requires both YidC and PMF in vivo. We analyzed the mechanisms that determine the insertion factor dependency in vitro. Glycolipid MPIase was required for insertion of both proteins because MPIase depletion caused a significant defect in insertion. On the other hand, YidC depletion and PMF dissipation had no effects on Pf3-Lep insertion, whereas V15D insertion was reduced. We reconstituted (proteo)liposomes containing MPIase, YidC, and/or F0F1-ATPase. MPIase was essential for insertion of both proteins. YidC and PMF stimulated Pf3-Lep insertion as the synthesis level increased. V15D insertion was stimulated by both YidC and PMF irrespective of the synthesis level. These results indicate that charges in the N-terminal region and the synthesis level are the determinants of YidC and PMF dependencies with the interplay between MPIase, YidC, and PMF.

scholarly journals A Comparative Study on Shi‘îte Tafsîr of the Qur’an 24: 55 and the Bible Isaiah 11:1-9: Theology of Hope in the Concept of Mahdism and Messianism

MUTAWATIR ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 215-234
Author(s):  
Luthfi Rahman
Keyword(s):  
Comparative Study ◽  
The State ◽  
The Other ◽  
The Bible ◽  
Other Hand ◽  
Library Research ◽  
Theological Discourse ◽  
Biblical Commentaries ◽  
The Ideal

This paper engages with the theological discourse on the state of al-Mahdi in Shi‘i tradition and the Peaceful Kingdom of Christianity. It focuses on two particular narratives, Quranic one focusing on Shi‘i tafsir Qur’an 24:55 and Biblical one concerning on Isaiah 11:1-19. This study employs library research looking specifically at Qur’anic and Biblical commentaries. By comparing the texts, it is found out that the first insists on several requirements to realize the promise of God (the state of al-Mahdî) by performing active struggles i.e. possessing strong faith and doing righteous action. On the other hand, the latter provides the description of the ideal circumstance when Messiah comes to a region in which both the ruler and the ruled do active struggles. The first still emphasizes the importance of strong faith while the second doesn’t. Yet, both narratives share that active struggles and righteous actions must be at stake.

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