Acupuncture and Gastric Acid Studies

1979 ◽  
Vol 07 (04) ◽  
pp. 356-361 ◽  
Author(s):  
Joseph O. A. Sodipo ◽  
J. M. Falaiye
Keyword(s):  
Duodenal Ulcer ◽  
Pain Relief ◽  
Gastric Acid ◽  
Acid Output ◽  
Symptomatic Relief ◽  
Ulcer Group ◽  
History Of ◽  
Basal Acid ◽  
The Mean ◽  
The Difference

The effects of therapeutic acupuncture on gastric acid secretion on pain relief in chronic duodenal ulcer patients were studied. Ten adult Nigerian patients with clinical, endoscopic as well as radiological evidence of duodenal ulcer constituted the "Ulcer Group". Four other patients who gave history of dyspepsia formed the "Dyspeptic Group". Pentagastrin stimulation test was performed on all subjects pre- and post-acupuncture therapy. The classical Chinese acupuncture loci were employed. The mean Basal Acid Output (BAO) in the duodenal ulcer group was markedly reduced from 4.04 ±1.01 mMols/hour to 1.05±2.5mMols/hour. The mean Maximal Acid Output (MAO) was lowered from 34.72±13.81 mMols/hour to 15.34±4.01 mMols/hour. The difference was statistically significant (P<0.001). It is more probable, therefore, that the relief of pain is attributable to the therapeutic inhibition of gastric hyperacidity in our patients. Thus, though pain relief has been previously demonstrated in response to acupuncture, the results of this investigation have gone further to show that acupuncture achieves symptomatic relief through therapeutic gastric depression in duodenal ulcer patients.

Ranitidine plus Bromazepam in the Treatment of Duodenal Ulcer: Effect on Gastric Acid Secretion

1989 ◽  
Vol 17 (1) ◽  
pp. 55-61 ◽  
Author(s):  
E. García-Oyola ◽  
W. I. Curioso
Keyword(s):  
Duodenal Ulcer ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Rating Scale ◽  
Acid Output ◽  
Self Assessment ◽  
Double Blind ◽  
Emotional Environment ◽  
Basal Acid

The effect of adding bromazepam to treatment of duodenal ulcer with ranitidine was investigated in 30 out-patients. Under double-blind conditions one group of 15 patients received, for 14 days, 300 mg ranitidine and 6 mg bromazepam in the evening as a single dose. The other group received the same dose of ranitidine together with placebo, also for 14 days. In addition to measurements of gastric acid secretion after fasting and following histamine provocation, psychological ratings (Hamilton Anxiety Rating Scale and Zung Self-Assessment Scale for Anxiety) were carried out. Basal acid secretion was the same in both groups. During treatment, maximal acid output was significantly lower in the group of patients taking bromazepam than in those taking placebo. Similarly, significant differences were seen in favour of bromazepam in the psychological tests. It is concluded that these results confirm that bromazepam exerts a significant influence on acidity, over and above the effect of ranitidine. This effect, in all probability, is modulated by the emotional environment of individuals.

Incidence and prognosis of patients with spinal metastasis as the initial manifestation of malignancy

2019 ◽  
Vol 101-B (11) ◽  
pp. 1379-1384 ◽  
Author(s):  
Jin-Sung Park ◽  
Se-Jun Park ◽  
Chong-Suh Lee
Keyword(s):  
Surgical Treatment ◽  
Spinal Metastasis ◽  
Spinal Disease ◽  
Primary Malignancy ◽  
Initial Manifestation ◽  
Kaplan Meier ◽  
History Of ◽  
The Mean ◽  
The Difference

Aims This study aimed to evaluate the incidence and prognosis of patients with spinal metastasis as the initial manifestation of malignancy (SM-IMM). Patients and Methods We retrospectively reviewed the electronic medical records of 338 patients who underwent surgical treatment for metastatic spinal disease. The enrolled patients were divided into two groups. The SM-IMM group included patients with no history of malignancy whose site of primary malignancy was diagnosed after the identification of spinal metastasis. The other group included patients with a history of treatment for primary malignancy who then developed spinal metastasis (SM-DTM). The incidence of SM-IMM by site of primary malignancy was calculated. The difference between prognoses after surgical treatment for SM-IMM and SM-DTM was established. Results The median follow-up period was 11.5 months (interquartile range (IQR) 3.2 to 13.4) after surgical treatment. During the follow-up period, 264 patients died; 74 patients survived. The SM-IMM group consisted of 94 patients (27.8%). The site of primary malignancy in the SM-IMM group was lung in 35/103 patients (34.0%), liver in 8/45 patients (17.8%), kidney in 10/33 patients (30.3%), colorectum in 3/29 patients (10.3%), breast in 3/22 patients (13.6%), prostate in 3/10 patients (30%), thyroid in 4/8 patients (50%), and ‘other’ in 28/88 patients (31.8%). On Kaplan–Meier survival analysis, the SM-IMM group showed a significantly longer survival than the SM-DTM group (p = 0.013). The mean survival time was 23.0 months (95% confidence interval (CI) 15.5 to 30.5) in the SM-IMM group and 15.5 months (95% CI 11.8 to 19.2) in the SM-DTM group. Conclusion Of the 338 enrolled patients who underwent surgical treatment for spinal metastasis, 94 patients (27.8%) underwent surgical treatment for SM-IMM. The SM-IMM group had an acceptable prognosis with surgical treatment. Cite this article: Bone Joint J 2019;101-B:1379–1384.

Neurotensin and oxyntomodulin-(30-37) potentiate PYY regulation of gastric acid and somatostatin secretions

1993 ◽  
Vol 265 (1) ◽  
pp. G113-G117 ◽  
Author(s):  
A. Bado ◽  
D. Cloarec ◽  
L. Moizo ◽  
J. P. Laigneau ◽  
D. Bataille ◽  
...  
Keyword(s):  
Gastric Acid ◽  
Intravenous Infusion ◽  
Peptide Yy ◽  
Acid Output ◽  
The Other ◽  
Gastric Fistula ◽  
Gastric Acid Output ◽  
Heidenhain Pouch ◽  
Basal Acid ◽  
Gastric Secretions

The present study was designed to investigate, in cats provided with both a gastric fistula and a denervated fundic Heidenhain pouch, the effect of peptide YY (PYY) on pentagastrin-stimulated gastric acid and somatostatin secretions and to determine whether neurotensin (NT) and the COOH-terminal octapeptide of oxyntomodulin [Oxm-(30-37)] would modify these secretions. Intravenous infusion of PYY (0.1 nmol.kg-1.h-1), NT (15 nmol.kg-1.h-1), or Oxm-(30-37) (60 nmol.kg-1.h-1) did not affect basal acid secretion. However, they significantly inhibited pentagastrin-stimulated gastric acid output up to 50% (P < 0.01) in the main stomach. Furthermore, they significantly increased gastric somatostatin release by +750, +1,700, and +600% over basal level (P < 0.01) for (in nmol.kg-1.h-1) 0.1 PYY, 15 NT, and 60 Oxm-(30-37), respectively. On the other hand, the effects of 0.1 nmol.kg-1.h-1 PYY were potentiated by subthreshold doses of NT (5 nmol.kg-1.h-1) or Oxm-(30-37) (15 nmol.kg-1.h-1). These findings suggest that there could be a cooperation between the three peptides in the intestinal regulation of gastric secretions.

scholarly journals Outcome of Type 1 tympanoplasty: An experience at Biratnagar eye hospital in Eastern Nepal

2015 ◽  
Vol 7 (2) ◽  
pp. 55-60 ◽  
Author(s):  
Sanjeev Kumar Thakur ◽  
Sanjay Kumar Singh ◽  
Anwar Afaque ◽  
Nisha Ghimire
Keyword(s):  
Medical Sciences ◽  
Hearing Improvement ◽  
Hearing Outcome ◽  
Type 1 Tympanoplasty ◽  
Younger Age ◽  
History Of ◽  
The Mean ◽  
The Difference ◽  
Graft Success

Background: The history of tympanoplasty is well over a century. Type 1 tympanoplasty is an established procedure worldwide with a variation in the outcome.Aims and Objectives: To analyze the outcome of Type 1 tympanoplasty surgeries in terms of graft success and hearing improvement done at the Ear Department of Biratnagar eye hospital in eastern Nepal and discuss the various factors that might have influenced it.Materials and Methods: Retrospective analysis of records of the cases that underwent Type 1 tympanoplasty from August 2013 to January 2015 was done. The factors analysed were age, gender, the side of the affected ear and the perforation size. Appropriate Statistical test was applied and the results were discussed.Results: A total of 151 cases of type 1 Tympanoplasty were analysed were females had higher frequency than males, with higher incidence at younger age. The mean age of successful cases was 28.53. Females had a better success rate in terms of graft success compared to males. Moderate size perforations had the best outcome of graft success and least were of small size perforations. Of all cases analyzed, hearing improvement was observed in maximum cases.Conclusion: There was no significant influence of age or gender on the hearing outcome. The difference of hearing improvement according to size of perforation was also not significant.Asian Journal of Medical Sciences Vol.7(2) 2015 55-60

Gastric acid output, bacterial load and gastritis in Helicobacter pylori positive patients with duodenal ulcer

1995 ◽  
Vol 108 (4) ◽  
pp. A147
Author(s):  
PH Le Roux ◽  
AW Harris ◽  
MM Walker ◽  
JJ Misiewicz ◽  
JH Baron
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Gastric Acid ◽  
Acid Output ◽  
Bacterial Load ◽  
Gastric Acid Output

scholarly journals Evaluation of multiple risk factors involved in the development of Diabetic Retinopathy

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Syeda Birjees Anwar ◽  
Naveed Asif ◽  
Syed Abid Hassan Naqvi ◽  
Sidra Malik
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Family History ◽  
Positive Family History ◽  
Family History Of Diabetes ◽  
Duration Of Diabetes ◽  
Multiple Risk Factors ◽  
History Of ◽  
The Mean ◽  
The Difference

Objective: To determine the role of hypertension, hyperlipidemia, smoking and positive family history of diabetes and hypertension in the development of diabetic retinopathy. Methods: This prospective cohort study was conducted at the Department of Chemical Pathology, Armed Forces Institute of Pathology, Rawalpindi over 2 years period from June 2014 to June 2016. One hundred consecutive diabetic patients with no signs of diabetic retinopathy and good glycemic control (HbA1c<6.5%) were registered by non-probability convenient sampling after taking written informed consent. They were evaluated for hypertension, hyperlipidemia and smoking status. These patients were then followed 6 monthly for 2 years to look for the development of diabetic retinopathy. Results: The mean age of the patients was 50.72±9.29 years and there were 57 (57%) male and 43 (43%) female patients. Majority (82%) of the patients had NIDDM. The mean duration of diabetes was 8.31±6.83 years. 11% of the patients were smoker, 37% were hypertensive, 6% had hyperlipidaemia, 62% had family history of diabetes and 30% had family history of hypertension. At the end of follow-up, 9 (9.0%) patients had diabetic retinopathy. The frequency of diabetic retinopathy increased with increasing age of the patient; however, the difference was statistically insignificant. A comparatively higher frequency of diabetic retinopathy was also seen in patients with IDDM and those with positive family history of diabetes and hypertension yet again, the difference was statistically insignificant. Also, no significant difference was noted among male and female genders and smokers vs. non-smoker. However, the frequency of diabetic retinopathy increased significantly with increasing duration of diabetes. It was also higher among those with hypertension and hyperlipidemia. Conclusion: Higher patient age (≥50 years), increasing duration of diabetes (≥20 years), insulin dependent diabetes mellitus, hypertension, hyperlipidemia, and positive family history of diabetes and hypertension were found to be associated with increased frequency of diabetic retinopathy. How to cite this:Anwar SB, Asif N, Naqvi SAH, Malik S. Evaluation of multiple risk factors involved in the development of Diabetic Retinopathy. Pak J Med Sci. 2019;35(1):---------. doi: https://doi.org/10.12669/pjms.35.1.279 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development

2010 ◽  
Vol 59 (12) ◽  
pp. 1484-1489 ◽  
Author(s):  
Shinobu Imagawa ◽  
Masanori Ito ◽  
Masaharu Yoshihara ◽  
Hidetaka Eguchi ◽  
Shinji Tanaka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Duodenal Ulcer ◽  
Gastric Acid ◽  
Acid Output ◽  
Rank Test ◽  
Peptic Ulcers ◽  
Log Rank Test ◽  
H Pylori

Few reports have described the cancer prevalence of peptic ulcer patients with long-term follow-up studies. We have conducted a long-term retrospective cohort study of Japanese peptic ulcer patients and evaluated the risk factors for the occurrence of gastric cancer (GCa). A total of 136 patients diagnosed with peptic ulcers from 1975 to 1983 were enrolled. These 136 cases [102 males and 34 females; 69 gastric ulcer (GU) and 67 duodenal ulcer (DU) patients at the time of enrolment; mean follow-up period of 14.4 years (range 1–30 years)] after being matched with a tumour registry database in Hiroshima prefecture were surveyed for GCa. We investigated Helicobacter pylori duodenal ulcer promoter gene A (dupA) using paraffin-embedded gastric biopsy specimens in 56 cases. Gastric acid secretion and basal acid output (BAO) in 40 cases, and maximal acid output in 68 cases, had been measured at first diagnosis of peptic ulcers. GCa was detected in 24 patients (17 with GU, 7 with DU) during the follow-up. The prevalence of GCa was significantly higher in GU patients than in DU patients (log-rank test P<0.05). dupA-positive H. pylori was detected not only in DU patients (9/20) but also in GU patients (9/36). Gastric acid output was significantly larger in quantity in patients with dupA-positive H. pylori than in those with dupA-negative H. pylori (P<0.05). The occurrence of GCa was significantly lower in patients with dupA-positive H. pylori and a high BAO level (log-rank test P<0.05). DUs, higher acid output and dupA-positive H. pylori were negatively associated with GCa.

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