Core–Shell γ-Fe2O3/SiO2/PCA/Ag-NPs Hybrid Nanomaterials as a New Candidate for Future Cancer Therapy

2014 ◽  
Vol 13 (01) ◽  
pp. 1450008 ◽  
Author(s):  
R. Soleyman ◽  
A. Pourjavadi ◽  
N. Masoud ◽  
A. Varamesh
Keyword(s):  
Silver Nanoparticles ◽  
Cancer Therapy ◽  
Silver Ions ◽  
Core Shell ◽  
Capping Agent ◽  
Hybrid Nanomaterials ◽  
Ag Nps ◽  
Core Nanoparticles ◽  
Size And Structure

In the current study, γ- Fe 2 O 3/ SiO 2/ PCA / Ag -NPs hybrid nanomaterials were successfully synthesized and characterized. At first, prepared γ- Fe 2 O 3 core nanoparticles were modified by SiO 2 layer. Then they were covered by poly citric acid (PCA) via melting esterification method as well. PCA shell acts as an effective linker, and provides vacancies for conveying drugs. Moreover, this shell as an effective capping agent directs synthesis of silver nanoparticles ( Ag -NPs) via in situ photo-reduction of silver ions by sunlight-UV irradiation. This system has several benefits as a suitable cancer therapy nanomaterial. Magnetic nanoparticles (MNPs) can guide Ag -NPs and drugs to cancer cells and then Ag -NPs can affect those cells via Ag -NPs anti-angiogenesis effect. Size and structure of the prepared magnetic hybrid nanomaterials were characterized using FTIR and UV-Vis spectra, AFM and TEM pictures and XRD data.

scholarly journals Single-Step Green Synthesis of Highly Concentrated and Stable Colloidal Dispersion of Core-Shell Silver Nanoparticles and Their Antimicrobial and Ultra-High Catalytic Properties

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1007
Author(s):  
Azam Ali ◽  
Mariyam Sattar ◽  
Fiaz Hussain ◽  
Muhammad Humble Khalid Tareen ◽  
Jiri Militky ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Green Synthesis ◽  
Tannic Acid ◽  
Rate Constant ◽  
Catalytic Properties ◽  
Colloidal Dispersion ◽  
Alkaline Condition ◽  
Core Shell ◽  
Average Particle ◽  
Ag Nps

The versatile one-pot green synthesis of a highly concentrated and stable colloidal dispersion of silver nanoparticles (Ag NPs) was carried out using the self-assembled tannic acid without using any other hazardous chemicals. Tannic acid (Plant-based polyphenol) was used as a reducing and stabilizing agent for silver nitrate in a mild alkaline condition. The synthesized Ag NPs were characterized for their concentration, capping, size distribution, and shape. The experimental results confirmed the successful synthesis of nearly spherical and highly concentrated (2281 ppm) Ag NPs, capped with poly-tannic acid (Ag NPs-PTA). The average particle size of Ag NPs-PTA was found to be 9.90 ± 1.60 nm. The colloidal dispersion of synthesized nanoparticles was observed to be stable for more than 15 months in the ambient environment (25 °C, 65% relative humidity). The synthesized AgNPs-PTA showed an effective antimicrobial activity against Staphylococcus Aureus (ZOI 3.0 mM) and Escherichia coli (ZOI 3.5 mM). Ag NPs-PTA also exhibited enhanced catalytic properties. It reduces 4-nitrophenol into 4-aminophenol in the presence of NaBH4 with a normalized rate constant (Knor = K/m) of 615.04 mL·s−1·mg−1. For comparison, bare Ag NPs show catalytic activity with a normalized rate constant of 139.78 mL·s−1·mg−1. Furthermore, AgNPs-PTA were stable for more than 15 months under ambient conditions. The ultra-high catalytic and good antimicrobial properties can be attributed to the fine size and good aqueous stability of Ag NPs-PTA. The unique core-shell structure and ease of synthesis render the synthesized nanoparticles superior to others, with potential for large-scale applications, especially in the field of catalysis and medical.

scholarly journals Catalytic and anti-bacterial properties of biosynthesized silver nanoparticles using native inulin

RSC Advances ◽  
2018 ◽  
Vol 8 (50) ◽  
pp. 28746-28752 ◽  
Author(s):  
Wei Xu ◽  
Kunling Huang ◽  
Weiping Jin ◽  
Denglin Luo ◽  
Huan Liu ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Capping Agent ◽  
Ag Nps ◽  
Incubation Temperatures

Silver nanoparticles (Ag NPs) were green synthesized using native inulin as the reducing and capping agent with varied incubation temperatures, incubation times and Ag+ concentrations.

Silver Ions Release from Antibacterial Chitosan Films Containing in Situ Generated Silver Nanoparticles

2012 ◽  
Vol 61 (1) ◽  
pp. 260-267 ◽  
Author(s):  
Gracia López-Carballo ◽  
Laura Higueras ◽  
Rafael Gavara ◽  
Pilar Hernández-Muñoz
Keyword(s):  
Silver Nanoparticles ◽  
Silver Ions ◽  
Chitosan Films

Silver nanoparticles used to counter Monilinia fructicola fungicide-resistance and reduce fungicide environmental footprint 

2021 ◽  
Author(s):  
Constantinos Chrysikopoulos ◽  
Anastasios A. Malandrakis ◽  
Nektarios Kavroulakis ◽  
Anthi Stefanarou
Keyword(s):  
Silver Nanoparticles ◽  
Control Plant ◽  
Resistance Mutation ◽  
Silver Ions ◽  
Apple Fruit ◽  
Ag Nps ◽  
Gene Target ◽  
Benzimidazole Fungicides

<div><span>The potential of silver nanoparticles (Ag-NPs) to control plant pathogen <em>Monilia</em><em>fructicola </em>and to deter environmental contamination by reducing fungicide doses was evaluated <em>in vitro </em>and <em>in vivo. </em> </span>F<span>ungitoxicity screening </span>of <em><span>M. fructicola </span></em><span>isolates resulted in the detection of 18 benzimidazole-resistant (BEN-R) isolates with reduced sensitivity to fungicides  thiophanate methyl (TM)  and carbendazim. All resistant isolates caried the E198A resistance mutation in their </span><em><span>β</span>-</em>tubulin gene, target site of the benzimidazole fungicides. <span>Ag-NPs could effectively control both sensitive (BEN-S) and resistant isolates while the combination of Ag-NPs with TM significantly enhanced their fungitoxic effect both <em>in vitro </em>and in apple fruit tests. The positive correlation observed between Ag-NPs and TM+Ag-NPs treatments indicates a mixture-enhanced Ag-NPs activity/availability as a possible mechanism of synergy. No correlation between Ag-NPs  and AgNO<sub>3 </sub>could  be found suggesting difference(s) in the fungitoxic mechanism of action between Nps and their bulk/ionic counterparts. Indications of the involvement of energy (ATP) metabolism in the mode of action of Ag-NPs were also evident by the synergy observed between Ag-NPs and the </span>oxidative phosphorylation<span>-uncoupler fluazinam (FM) against both BEN-R and BEN-S phenotypes. The role of silver ions release on the inhibitory action of Ag-NPs against the fungusis probably limited since the AgNPs/NaCl combination enhanced fungitoxicity, a fact that could not be justified by the expected binding of silver with chlorine ions. Concluding, Ag-NPs can be effectively used as a means of controlling both BEN-S and BEN-R <em>M. </em><em>fructicola </em>isolates </span>while <span>their combination with conventional fungicides should aid anti-resistant strategies and reduce the environmental impact of synthetic fungicides by reducing effective doses to the control the pathogen.</span></div>

scholarly journals Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

Molecules ◽  
2020 ◽  
Vol 25 (5) ◽  
pp. 1063 ◽  
Author(s):  
Janet Olayemi Olugbodi ◽  
Oladipupo David ◽  
Ene Naomi Oketa ◽  
Bashir Lawal ◽  
Bamidele Joseph Okoli ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Hematological Parameters ◽  
Silver Ions ◽  
Thiol Group ◽  
Sperm Parameters ◽  
Male Rats ◽  
Ag Nps ◽  
Hematological Indices ◽  
Electron Microscopies ◽  
Pharmaceutical Application

The potential pharmaceutical application of nanoparticles has led to the toxicity within the male reproductive system. In the present study, the effects of silver nanoparticles (Ag-NPs) on hematological parameters, free radical generation, antioxidant system, sperm parameters, and organ histo-morphometry in male rats were investigated. Ag-NPs were produced by the reduction of silver ions, while the formation of which was monitored by UV–visible spectrophotometry. Zeta potential, transmission, and scanning electron microscopies were applied for the characterization of AgNPs. A total of 30 rats were divided into 6 groups and were sub-dermally exposed to Ag-NPs at the dosage of 0 (control), 10, and 50 mg/kg bodyweight (bw) doses for either 7 or 28 days. Ag-NP administration altered hematological indices and caused dose-dependent decreases in sperm motility, velocity, kinematic parameters, concentrations of luteinizing hormone, follicle-stimulating hormone, and testosterone. In the epididymis and testis, the concentrations of malondialdehyde and peroxide increases while superoxide dismutase, catalase, reduced glutathione, and total thiol group decreases. These findings suggest that Ag-NP triggered hormonal imbalance and induce oxidative stress in testis and epididymis; which negatively affect sperm parameters of male rats.

Evolution Analysis of Silver Nanoparticles Synthesised by Lactam Reduction: A Case Study of ϵ-Caprolactam

2018 ◽  
Vol 71 (8) ◽  
pp. 587 ◽  
Author(s):  
Na Zhang ◽  
Jianping Duan ◽  
Dajiang Zhao ◽  
Guisheng Yang
Keyword(s):  
Silver Nanoparticles ◽  
Size Distribution ◽  
Ostwald Ripening ◽  
Silver Ions ◽  
Reducing Agents ◽  
Ag Nps ◽  
Second Stage ◽  
Evolution Analysis ◽  
Ostwald Ripening Mechanism

Without using protecting agent and solvent, silver nanoparticles (Ag NPs) were synthesised by using lactams as reducing agents. Being the most commercially available lactam, ϵ-caprolactam (CL) was taken as a model to illustrate the evolution of Ag NPs in the medium of lactams. The results showed that there were two different stages involved in the Ag NP evolution process. In the first stage, particles were stabilised against further coalescence at a smaller size (< 5 nm) because of face-bound CL. In the second stage, the Ostwald ripening mechanism cooperated with continuous reduction of residual silver ions, which resulted in the resultant particles being distributed with different size distribution. The participation of CL in the reducing and protecting procedures raised a complex evolution of Ag NPs.

scholarly journals Nanoparticle induced formation of self-assembled zwitterionic surfactant microdomains which mimic microemulsions for the in situ fabrication and dispersion of silver nanoparticles

RSC Advances ◽  
2020 ◽  
Vol 10 (56) ◽  
pp. 34161-34166
Author(s):  
Taichi Nakagawa ◽  
Akihide Hibara ◽  
Willie L. Hinze ◽  
Yoshitaka Takagai
Keyword(s):  
Silver Nanoparticles ◽  
Zwitterionic Surfactant ◽  
Ag Nps ◽  
In Situ Fabrication ◽  
Self Assembled

The illustration of the mechanism of fabrication of dispersive microemulsion enclosing Ag-NPs.

In situ reduction of antibacterial silver ions to metallic silver nanoparticles on bioactive glasses functionalized with polyphenols

2017 ◽  
Vol 396 ◽  
pp. 461-470 ◽  
Author(s):  
S. Ferraris ◽  
M. Miola ◽  
A. Cochis ◽  
B. Azzimonti ◽  
L. Rimondini ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Silver Ions ◽  
Metallic Silver ◽  
In Situ Reduction ◽  
Bioactive Glasses

scholarly journals Copolymerization of Quinazolinone Derivatives With Styrene, Methyl Methacrylate and Their Silver Nanocomposites for Biological Applications

2021 ◽  
Author(s):  
Karim Samy El-Said ◽  
Ahmed Ahmed El-Barbary ◽  
Hazem M. ElKholy ◽  
Ahmed S. Haidyrah ◽  
Mohamed Betiha ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Methyl Methacrylate ◽  
Silver Ions ◽  
Xrd Analysis ◽  
Antibacterial Activities ◽  
Mice Model ◽  
Ag Nps ◽  
Silver Nanocomposites ◽  
Amorphous Structures

Reaction of 2-mercapto-3-phenylquinazolin-4(3H)-one (MPQ) with both 4-vinyl benzyl chloride and allyl bromide furnished the reactive heterocyclic monomers 3-phenyl-2-((4-vinylbenzyl) thio) quinazolin-4(3H)-one (PVTQ) and 2-(allylthio)-3-phenylquinazolin-4(3H)-one (APQ), respectively. Copolymerization of PVTQ monomer with styrene and methyl methacrylate in the presence of 2,2&prime;-azobisisobutyronitrile (AIBN) afforded the copolymers PS-co-PPVTQ and PMMA-co-PPVTQ, respectively. Similarly, copolymerization of monomer APQ with styrene and methyl methacrylate (MMA) afforded the copolymers PS-co-PAPQ and PMMA-co-PAPQ, respectively. The resulted copolymers were characterized by using FT-IR, 1H-NMR and GPC techniques. Silver nanocomposites of PS, PMMA, PS-co-PPVTQ, PMMA-co-PPVTQ, PS-co-PAPQ and PMMA-co-PAPQ were synthesized by the addition of silver nitrate into the polymer solution. The reduction of silver ions into silver nanoparticles was performed in DMF and water. Thermogravimetric (TGA) analysis was used to determine the thermal stability of the copolymers and their silver nanocomposites. The X-ray diffraction (XRD) analysis indicated the amorphous structures of the co-polymers and confirmed the formation of silver nanoparticles. The antitumor and antibacterial activities were screened for the copolymers and enhanced by the formation of their silver nanocomposites. In vivo antitumor activity in Ehrlich Ascitic Carcinoma (EAC) mice model showed that PS-co-PPVTQ/Ag NPs, PMMA-co-PPVTQ/Ag NPs, and PMMA-co-PAPQ/Ag NPs displayed promising inhibitory effects against EAC and induce apoptosis against MCF-7 cells.

Catechol End-Functionalized Polysarcosine for In-situ Synthesis and Stabilization of Silver Nanoparticles

MRS Advances ◽  
2020 ◽  
Vol 5 (21-22) ◽  
pp. 1113-1120
Author(s):  
Hailemariam Gebru ◽  
Zhenjiang Li
Keyword(s):  
Silver Nanoparticles ◽  
Metallic Nanoparticles ◽  
In Situ Synthesis ◽  
High Concentration ◽  
Ag Nps ◽  
Sem Images ◽  
Stabilizing Agents ◽  
H Nmr ◽  
Dopamine Hydrochloride

ABSTRACTFunctional polymers were previously employed to minimize the susceptibility of metallic nanoparticles (MNPs) for aggregation. Herein, we intended to conjugate catechol moiety into the polymer chain end considering its anchoring ability to virtually most surfaces. Accordingly, catechol end-functionalized polysarcosine (cat-PSar) was successfully prepared from the ring-opening polymerization (ROP) of sarcosine N-carboxyanhydrides (Sar-NCA) using dopamine hydrochloride initiator. ROP of Sar-NCA was carried out at different monomer to initiator feed ratios. The molecular structure of cat-PSar was confirmed by 1H NMR and MALDITOF. Afterward, the obtained catechol functionalized polymer was used for in-situ synthesis and stabilization of silver nanoparticles (Ag-NPs) in aqueous solution. The observed characteristic absorption peak at λmax of 415 nm indicates the formation of Ag-NPs. Scanning electron microscope (SEM) images also elucidate the formation of Ag-NPs with the relatively small sizes of the nanocomposite at a high concentration of silver nitrate. Hence, biomimetic polymers could play a dual role as reducing and stabilizing agents in the preparation of monodispersed MNPs.

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