CASE REPORT: ENDOMETRIAL STROMAL SARCOMA AND LIPOSARCOMA IN AN AFRICAN HEDGEHOG (Atelerix albiventris)

2016 ◽  
Vol 42 (03) ◽  
pp. 181-186 ◽  
Author(s):  
Fang-Yi Tsai ◽  
Hui-Ming Chang ◽  
Hao-Kai Chang ◽  
Ju-Pai Kao ◽  
Jiunn-Wang Liao
Keyword(s):  
Smooth Muscle Actin ◽  
Abdominal Mass ◽  
Endometrial Stromal Sarcoma ◽  
Surgical Excision ◽  
Exploratory Laparotomy ◽  
Species Interaction ◽  
Neoplastic Cells ◽  
Stromal Sarcoma ◽  
Subcutaneous Mass ◽  
The Right

A 2-year-7-month-old female intact African hedgehog was presented with a subcutaneous mass around the right side of the neck as well as an intra-abdominal mass found during palpation. Surgical excision and exploratory laparotomy were performed. A uterine mass was identified during laparotomy and ovariohysterectomy was performed. The botryoid mass measured [Formula: see text][Formula: see text]cm and was located in the right uterine horn. It had a meat-like texture and was yellow-white and dark red in color. The removed subcutaneous mass measured [Formula: see text][Formula: see text]cm. The mass was well-encapsulated and had a yellow-white homogeneous texture on the cut surface. Histologically, the myometrium was invaded by neoplastic cells and the tissue boundaries were not obvious. Neoplastic cells were arranged in a whirling or intersecting pattern, with strong angiogenesis present. Vacuolated nuclei were round and oval to cigar shaped, with one to multiple nucleoli present. Immunohistochemistry revealed a positive reaction for CD10, but a negative reaction for smooth muscle actin (SMA) and desmin in the uterine neoplastic cells. Histologically, well-differentiated adipocytes with sheets of undifferentiated polygonal neoplastic cells, which were characterized by vacuolated nuclei with prominent multiple nucleoli, were found in the subcutaneous mass. Neoplastic cells of the subcutaneous mass were positively stained with antibodies of MDM2 and estrogen receptor (ER), but failed to give a positive result for vimentin because the cross-species interaction was insufficient. The definitive diagnosis was endometrial stromal sarcoma and liposarcoma in an African hedgehog.

scholarly journals JAZF1–SUZ12 endometrial stromal sarcoma forming subserosal masses with extraordinary uptake of fluorodeoxyglucose on positron emission tomography: a case report

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Koto Fujiishi ◽  
Shigenori Nagata ◽  
Rieko Kano ◽  
Chiaki Kubo ◽  
Maasa Shirayanagi ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Endometrial Stromal Sarcoma ◽  
Emission Tomography ◽  
Low Grade ◽  
Neoplastic Cells ◽  
Pelvic Magnetic Resonance Imaging ◽  
Stromal Sarcoma ◽  
Positron Emission ◽  
Mesenchymal Neoplasm ◽  
The Right

Abstract Background Low-grade endometrial stromal sarcoma (ESS) is rare mesenchymal neoplasm, recently specified as harboring JAZF1–SUZ12 rearrangement. Typical JAZF1–SUZ12 ESS is slow growing, in which high uptake of fluorodeoxyglucose (FDG) on positron emission tomography (PET) and subserosal masses are quite unusual. Case presentation A 69-year-old Japanese woman complained of urinary incontinence. Pelvic magnetic resonance imaging showed uterine lesions composed of (1) a 9 × 8 × 7-cm mass protruding from the right-anterior wall, (2) a 4.5-cm mass attached to the right-posterior wall, and (3) a 6.5-cm intramural mass in the fundus. FDG-PET demonstrated maximum standardized uptake value of 13.28 confined to the two subserosal masses (1 & 2) in contrast to no uptake of the intramural mass (3). She was diagnosed with a high-grade uterine sarcoma concomitant with leiomyomas and underwent total hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. The removed uterus had three tumors—two in the right-anterior and right-posterior subserosa, respectively, and the remaining in the fundal myometrium. Microscopically, the three tumors shared morphologic features characterized by neoplastic cells similar to proliferative-phase endometrial stromal cells, in which neither round-cell component, pleomorphism, nor high mitotic activity was recognized. Nuclear cyclin D1 immunostaining was identified 50% of neoplastic cells in the two subserosal tumors (1 &2) whereas < 1% positive cells in the intramural component (3). Reverse transcriptase-polymerase chain reaction showed the same-sized electrophoretic bands indicating JAZF1–SUZ12 gene fusion shared by the three uterine tumors and a focal tumor extension into the extrauterine vein. The patient is alive without evidence of recurrence at 14 months after surgery. Conclusions Pathologists and clinicians should not exclude the possibility of JAZF1–SUZ12 ESS even when uterine subserosal masses demonstrate extraordinary FDG uptake on PET. Molecular analysis is helpful for diagnostic confirmation of JAZF1–SUZ12 ESS with a complex growth pattern.

scholarly journals Novel CT Features of an Abdominal Gossypiboma in a Female Dog

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Mylene Auger ◽  
Shelly Olin ◽  
Federica Morandi
Keyword(s):  
Abdominal Mass ◽  
Granulomatous Inflammation ◽  
Exploratory Laparotomy ◽  
Clinical Findings ◽  
Subcutaneous Tissues ◽  
Subcutaneous Mass ◽  
Surgical Recovery ◽  
The Right ◽  
Ct Features

Case Description. An eight-year-old Golden Retriever was presented with hypercalcemia and a complex abdominal mass. Clinical Findings. A well-defined, heterogeneously contrast-enhancing, cavitary, soft tissue attenuating, non-organ associated abdominal mass was identified caudal to the right kidney. This mass was confluent with the distal tip of the right limb of the pancreas. A connected large, rim enhancing, cystic subcutaneous mass was also present in the right lumbar subcutaneous tissues, and there were multiple fistulous tracts through the hypaxial musculature. Treatment and Outcome. The dog underwent a surgical exploratory laparotomy and a gossypiboma was removed from the intra-abdominal mass; the cystic extra-abdominal mass was drained percutaneously. Surgical recovery was uneventful and a follow-up CT after 3 months was consistent with resolving granulomatous inflammation and fibrosis. Clinical Relevance. The presence of multiple peripherally enhancing tracts extending from the abdominal mass through the hypaxial musculature is a CT feature which has not yet been described in the veterinary literature. Additionally, incorporation of the pancreas into the abdominal mass has also not yet been described in the veterinary literature.

Oncocytic Lipoadenoma: Report of 3 Rare Cases Involving the Parotid Gland, Including a Synchronous Presentation With Paraganglioma of the Right Carotid Bifurcation and Literature Review

2021 ◽  
pp. 106689692110219
Author(s):  
John L.S. Cunha ◽  
Marco A. Peñalonzo ◽  
Ciro D. Soares ◽  
Bruno A.B. de Andrade ◽  
Mário J. Romañach ◽  
...  
Keyword(s):  
English Language ◽  
Smooth Muscle Actin ◽  
Salivary Gland Tumor ◽  
Surgical Excision ◽  
Carotid Bifurcation ◽  
Alpha Smooth Muscle Actin ◽  
S 100 ◽  
The Right ◽  
Adequate Management ◽  
Adipose Cells

Oncocytic lipoadenoma (OL) is a rare salivary gland tumor characterized by the presence of oncocytic cells and mature adipose tissue. To date, only 30 cases of OL have been reported in the English-language literature. We present 3 additional OL cases involving the parotid, including a synchronous presentation with paraganglioma of the right carotid bifurcation. Microscopically, both the OLs were composed of a mixed population of oncocytes and adipocytes in varying proportions surrounded by a thin, connective tissue fibrous capsule. Oncocytes were positive for pan-cytokeratins (CKs) AE1/AE3, epithelial membrane antigen, CK5, CK7, CK14, CK18, and CK19. Calponin, p63, alpha-smooth muscle actin, and carcinoembryonic antigen were negative. Vimentin and S-100 protein were positive only in adipose cells. Despite distinctive morphologic features, OL is often misdiagnosed, given its rarity. We hope to contribute to surgeons’ and pathologists’ awareness and knowledge regarding the existence of this tumor and provide adequate management through conservative surgical excision.

An Unusual Case of Metastatic Seminoma in a Dog

2015 ◽  
Vol 51 (6) ◽  
pp. 401-406 ◽  
Author(s):  
Danielle R. Dugat ◽  
Emily L. Medici ◽  
Mark C. Rochat ◽  
Jason A. Arble ◽  
Timothy A. Snider
Keyword(s):  
Lymph Node ◽  
Complete Blood Count ◽  
Abdominal Mass ◽  
Exploratory Laparotomy ◽  
Serum Biochemistry ◽  
Lymph Node Biopsy ◽  
Biological Behavior ◽  
Tissue Mass ◽  
Abdominal Radiographs ◽  
The Right

An 8 yr old, reportedly castrated male Boston terrier presented with a history of generalized hyperesthesia and intermittent shifting leg lameness. Physical examination revealed a caudal abdominal mass and bilateral shoulder pain. A complete blood count, serum biochemistry panel, and urinalysis were unremarkable. Thoracic radiographs demonstrated bony proliferation and lysis of the third sternebra, an expansile lesion of the left tenth rib, and lucency in both proximal humeral metaphyses. Abdominal radiographs and ultrasound revealed a soft tissue mass within the caudoventral right abdomen. Ultrasonography also revealed an enlarged lymph node within the right retroperitoneal space. Exploratory laparotomy identified the mass as a retained testicle. A cryptorchidectomy, lymph node biopsy, and bilateral percutaneous core biopsies of the proximal humeri were performed. Histopathologic examination revealed malignant seminoma of the testicle with metastasis to lymph node and bone. Adjuvant chemotherapy was recommended, but it was declined by the owner. All follow-up was lost. This case highlights a unique case for causative hyperesthesia secondary to a novel site of metastasis from malignant seminoma. Metastasis to bone has not been reported in humans or dogs and represents a very unusual and aberrant variant of the normally relatively benign biological behavior of seminoma in the dog.

scholarly journals Mucinous Ovarian Tumors With Anaplastic Mural Nodules: Case Report

2021 ◽  
Vol 8 ◽  
Author(s):  
Xinxin Zou ◽  
Hao Huang ◽  
Qingyu Zhang ◽  
Zhen Ma ◽  
Yumei Chen ◽  
...  
Keyword(s):  
Surgical Excision ◽  
Exploratory Laparotomy ◽  
Cystic Mass ◽  
Anaplastic Carcinoma ◽  
Diagnostic Methods ◽  
Cystic Tumors ◽  
Partition Walls ◽  
Poorly Differentiated ◽  
The Right ◽  
Mural Nodules

Ovarian mucinous cystic tumors may be associated with various types of mural nodules, which can be classified as benign or malignant (anaplastic carcinoma, sarcoma, carcinosarcoma). However, anaplastic malignant nodules have rarely been reported. Here, we present a case of a 35-year-old woman who presented with abdominal discomfort. Ultrasonography showed a large cystic mass in the pelvic and abdominal cavities measuring 337 × 242 mm. Abdominal computed tomography revealed upper anterior and posterior uterine pelvic cystic lesions based on multiple nodule partition walls and classes. During hospitalization, the patient underwent exploratory laparotomy, which revealed a poorly differentiated ovarian malignant tumor, and subsequent surgical excision was performed. The pathological analysis of the surgical samples of the right ovary revealed a mucinous ovarian tumor, while the mural nodules were classified as anaplastic carcinoma. After surgery, the patient started receiving chemotherapy. Unfortunately, the patient died 6 months later. Mucinous tumor occurring with an anaplastic carcinoma is rare, and the current diagnostic methods are not sufficient in providing an early and accurate diagnosis. Most patients are already in the advanced stage upon diagnosis and combined with poorly differentiated pathological features, the prognosis is extremely poor. Clinicians need to improve the clinical evaluation before surgery and conduct preoperative preparation and communication to improve the prognosis of patients as much as possible.

scholarly journals Surgical excision of a giant pedunculated hydatid cyst of the liver

2019 ◽  
Vol 2019 (7) ◽  
Author(s):  
Ayad Ahmad Mohammed ◽  
Sardar Hassan Arif
Keyword(s):  
Iliac Fossa ◽  
Abdominal Mass ◽  
Bile Leak ◽  
Surgical Excision ◽  
Cystic Lesions ◽  
Right Lobe ◽  
Abdominal Examination ◽  
The Right ◽  
Cyst Cavity ◽  
Tape Worm

Abstract Hydatid disease is caused by a tape worm Echinococcus Granulosus that lives in the intestines of the definitive host which is the dog or other carnivore. Human is the accidental intermediate host and become infected by ingesting contaminated vegetables or water with the eggs of the parasite. A-37-year old male presented with right side abdominal pain for 2 months. Abdominal examination showed a large right side abdominal mass extending from the right subcostal region to the right iliac fossa. CT-scan showed two cystic lesions in the right lobe of the and a third one extending to the pelvis. During surgery aspiration of 10 liters of bile stained fluid done. Excision of the cysts done. Tube drain put inside the cyst cavity with omentoplasty. There was bile leak to the drain which stopped over one month. The patient received anthelminthic medication for 3 months.

scholarly journals Mesenchymal hamartoma of the liver in adults: Case report

2014 ◽  
Vol 67 (11-12) ◽  
pp. 399-403 ◽  
Author(s):  
Tanja Lakic ◽  
Mirjana Zivojinov ◽  
Milivoje Vukovic ◽  
Jelena Ilic-Sabo ◽  
Tamara Boskovic
Keyword(s):  
Case Report ◽  
Cystic Lesion ◽  
Benign Lesion ◽  
Abdominal Mass ◽  
Surgical Excision ◽  
Cystic Neoplasm ◽  
Mesenchymal Hamartoma ◽  
Transplantation Surgery ◽  
Clinical Center ◽  
The Right

Introduction. Mesenchymal hamartoma of the liver is a benign lesion presenting as an enlarging abdominal mass in children less than 2 years of age. Fewer than 5% cases are present in individuals over 5 years of age, and this lesion is extremely rare in adults. It may affect the left or the right lobe of liver as a cystic or solid mass or both components may be present. The pathogenesis remains incompletely understood, but these lesions have generally been considered to represent a development abnormality in the bile duct plate formation. Case Report. In this report, we present a case of a 44-year-old man who was surgically treated at the Department of Abdominal, Endocrine and Transplantation Surgery of the Clinical Center of Vojvodina due to cystic lesion in the liver segment IV that had been verified by computed tomography imaging diagnostics. The patient was sent from a smaller health center with the diagnosis of echinococcosis. After the adequate preparation of the patient, surgical excision of the liver cystic lesion was done. Once a thorough histological examination had been performed, the diagnosis of mesenchymal hamartoma was made. Conclusion. Mesenchymal hamartoma of the liver is a benign tumor resulting from abnormal, intra-uterine development of bile ducts and has a delayed clinical manifestation, thus this lesion appears to be related to the processes of maturation. It is potentially premalignant lesion presenting as a solid and/or cystic neoplasm. Symptoms, laboratory results and radiographic imaging are nonspecific and inconclusive, so surgical excision of the whole lesion is the imperative for the definitive diagnosis.

scholarly journals Immunohistochemical panel to differentiate endometrial stromal sarcoma, uterine leiomyosarcoma and leiomyoma: something old and something new

2015 ◽  
Vol 68 (9) ◽  
pp. 710-717 ◽  
Author(s):  
Helena Hwang ◽  
Koji Matsuo ◽  
Kara Duncan ◽  
Elham Pakzamir ◽  
Huyen Q Pham ◽  
...  
Keyword(s):  
Predictive Value ◽  
Smooth Muscle Actin ◽  
Area Under The Curve ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Uterine Leiomyosarcoma ◽  
Operating Characteristics ◽  
Uterine Sarcomas ◽  
Stromal Sarcoma ◽  
Receiver Operating Characteristics Curve

AimsTo evaluate an immunohistochemical panel differentiating endometrial stromal sarcoma (ESS) from uterine leiomyosarcoma (ULMS) and leiomyoma (LM).Methods94 cases (28 ESS, 41 ULMS, 25 LM) were retrieved and arrayed. 10 immunomarkers (estrogen receptor (ER), progesterone receptor (PR), CD10, smooth muscle actin, desmin, h-caldesmon, transgelin, GEM, ASC1, stathmin1) were used. A predictive model was constructed and examined by receiver operating characteristics curve analysis to determine area under the curve (AUC).ResultsThe combination of ER+/PR+/CD10+/GEM−/h-caldesmon−/transgelin− can predict ESS versus ULMS with AUC predictive value of 0.872 (95% CI 0.784 to 0.961, p<0.0001). The combination of ER+/PR+/CD10+/h-caldesmon−/transgelin− can predict low grade (LG) ESS from ‘LG’ ULMS with AUC predictive value of 0.914 (95% CI 0.832 to 0.995, p<0.0001). Finally, ULMS and ESS, including the LGs, were more likely to be stathmin1+ than LM.ConclusionsDue to the different clinical course and management, adding novel antibodies (GEM, transgelin) to the well established immunohistochemistry panel seemed to be useful in distinguishing ESS from ULMS and LG ESS from ‘LG’ ULMS. Finally, stathmin1 expression could be of value in differentiating LM from uterine sarcomas.

scholarly journals Endometrial stromal sarcoma in a 20-year-old woman

2019 ◽  
Vol 12 (12) ◽  
pp. e228874
Author(s):  
Rubina Sohail ◽  
Shahlla Kanwal ◽  
Adnan Murtaza ◽  
Bushra Haq
Keyword(s):  
Adnexal Mass ◽  
Stage Iv ◽  
Endometrial Stromal Sarcoma ◽  
Final Diagnosis ◽  
Sexually Active ◽  
Uterine Sarcomas ◽  
Stromal Sarcoma ◽  
Pelvic Wall ◽  
The Right

Endometrial stromal sarcoma (ESS) is an uncommon and challenging condition comprising 10% of all uterine sarcomas and found in women 42–58 years of age. ESS is difficult to diagnose in young women as it masquerades as a leiomyoma. We report this tumour in a 20-year-old woman presenting with heavy and prolonged menses and urinary retention. She was not sexually active and did not give consent for pelvic examination. A preoperative diagnosis of a submucous leiomyoma with an adnexal mass was made. At laparotomy, the leiomyoma was found to be wedged between the cervix and the vagina, and was removed vaginally. A 5–6 cm retroperitoneal mass was adherent to the right pelvic wall, which was also removed. Histopathology of both specimens revealed ESS. The final diagnosis according to the International Federation of Gynaecology and Obstetrics classification was stage IV ESS. After oncology consult, she was referred for chemotherapy. She is now on follow-up.

scholarly journals Laparoscopic Sentinel Node Mapping with Surgical Staging following Hysteroscopic Endometrial Resection in Endometrial Stromal Sarcoma

2019 ◽  
pp. 1
Author(s):  
Phornsawan Wasinghon ◽  
Chyi-Long Lee
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Indocyanine Green ◽  
Uterine Cancer ◽  
Endometrial Stromal Sarcoma ◽  
Nodal Metastasis ◽  
Surgical Staging ◽  
Stromal Sarcoma ◽  
The Right ◽  
Hysteroscopic Resection

A 50-year-old woman presented with symptoms of abnormal uterine bleeding. Ultrasonography showed an intrauterine cavity nodule sized approximately 2 cm. A hysteroscopic resection was diagnosed. The histopathology revealed high-grade endometrial stromal sarcoma. The surgery was laparoscopic surgical staging with indocyanine green sentinel lymph node mapping. Two positive indocyanine green sentinel lymph node of the right and left pelvic nodes showed no nodal metastasis. Also, the five positive indocyanine green sentinel lymph node showed no nodal metastasis. The occult lymph nodes were dissected at the right and left pelvic nodes for nodes 4 and 9, respectively. Conclusively, hysteroscopic resection is beneficial for the diagnosis of uterine sarcoma. Notwithstanding, laparoscopy can be used for uterine cancer and the indocyanine green sentinel lymph node showed no false negative. The patient was stage IA.

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