ADJUNCTIVE THERAPY FOR FETLOCK FLEXURAL DEFORMITIES ACCOMPANIED BY A DEEP TISSUE INJURY IN A CALF: A CASE REPORT

2021 ◽  
pp. 1-5
Author(s):  
Natcha Thongrueang ◽  
Hsu-Hsun Lee
Keyword(s):  
Wound Healing ◽  
Case Report ◽  
Pressure Ulcer ◽  
Normal Saline ◽  
Tissue Injury ◽  
Platelet Rich Plasma ◽  
Lesion Size ◽  
Metacarpal Bone ◽  
Deep Tissue Injury ◽  
The Right

A five-day-old Holstein Friesian male calf was presented for the evaluation of severe fetlock flexural deformities with a large pressure ulcer over the right metacarpal bone. Superficial and deep digital flexor tenotomy was performed. The surgical wound recovered well, but 15 days after surgery, the skin over the pressure ulcer was starting to fall away and exposing tendon and muscle. A hoof toe-extension shoe was applied to decrease pressure on the wound. The wound had a moderate bacterial infection and slowly responded to cleansing twice a day with 0.9% normal saline, 10% povidone iodine and a topical antibiotic. Topical autologous platelet-rich plasma (PRP) was then applied to the lesion ([Formula: see text][Formula: see text]cm) twice. The wound showed rapid tissue regeneration, good quality wound healing and no complications. After PRP treatment, the lesion size decreased ([Formula: see text][Formula: see text]cm). At this point, 0.9% normal saline cleansing and a bandage were applied until the wound had completely healed. This case report suggests that the hoof toe-extension shoe and topical dressing with autologous PRP, as a combination treatment, could be effective for fetlock flexural deformities with skin defects or delayed wound healing in large animals.

Healing effects of curcumin nanoparticles in deep tissue injury mouse model.

2020 ◽  
Vol 18 ◽  
Author(s):  
Zirui Zhang ◽  
Shangcong Han ◽  
Panpan Liu ◽  
Xu Yang ◽  
Jing Han ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mrna Expression ◽  
Tissue Injury ◽  
Inflammatory Cells ◽  
Pcr Analysis ◽  
Protective Effects ◽  
Deep Tissue ◽  
Deep Tissue Injury

Background: Chronic inflammation and lack of angiogenesis are the important pathological mechanisms in deep tissue injury (DTI). Curcumin is a well-known anti-inflammatory and antioxidant agent. However, curcumin is unstable under acidic and alkaline conditions, and can be rapidly metabolized and excreted in the bile, which shortens its bioactivity and efficacy. Objective: This study aimed to prepare curcumin-loaded poly (lactic-co-glycolic acid) nanoparticles (CPNPs) and to elucidate the protective effects and underlying mechanisms of wound healing in DTI models. Methods: CPNPs were evaluated for particle size, biocompatibility, in vitro drug release and their effect on in vivo wound healing. Results : The results of in vivo wound closure analysis revealed that CPNP treatments significantly improved wound contraction rates (p<0.01) at a faster rate than other three treatment groups. H&E staining revealed that CPNP treatments resulted in complete epithelialization and thick granulation tissue formation, whereas control groups resulted in a lack of compact epithelialization and persistence of inflammatory cells within the wound sites. Quantitative real-time PCR analysis showed that treatment with CPNPs suppressed IL-6 and TNF-α mRNA expression, and up-regulated TGF-β, VEGF-A and IL-10 mRNA expression. Western blot analysis showed up-regulated protein expression of TGF-β, VEGF-A and phosphorylatedSTAT3. Conclusion: Our results showed that CPNPs enhanced wound healing in DTI models, through modulation of the JAK2/STAT3 signalling pathway and subsequent upregulation of pro-healing factors.

Biomechanical Analysis of a Serious Pressure Ulcer Case in a Real-World Scenario

2009 ◽  
Author(s):  
Eran Linder-Ganz ◽  
Nogah Shabshin ◽  
Amit Gefen
Keyword(s):  
Cell Death ◽  
Pressure Ulcer ◽  
Tissue Injury ◽  
Biomechanical Analysis ◽  
Sigmoid Function ◽  
Metabolic Demand ◽  
Physical Damage ◽  
Tissue Mass ◽  
Ulcer Case ◽  
Deep Tissue Injury

Deep tissue injury (DTI) is a serious pressure ulcer, characterized by necrotic tissue mass under intact skin. There is evidence that elevated tissue strains/stresses over prolonged times cause DTI, via paths of physical damage to cells, ischemia and impaired diffusion. Skeletal muscle is considered less tolerable to mechanical loads, likely because of higher metabolic demand and denser vascularization. When damaged in compression, muscle tissue stiffens up to ∼3-fold, depending on the magnitude and duration of loading [1]. Cell-death thresholds for loaded muscle, that are a Boltzmann-type downward-step sigmoid function of the magnitude of compression strain/stress and time, were developed based on meta-analysis of animal experiments [2]. These cell-death thresholds allow extrapolation of biological damage trends from computational stress analyses of muscle in load bearing postures.

scholarly journals Muscle apoptosis is induced in pressure-induced deep tissue injury

2009 ◽  
Vol 107 (4) ◽  
pp. 1266-1275 ◽  
Author(s):  
Parco M. Siu ◽  
Eric W. Tam ◽  
Bee T. Teng ◽  
Xiao M. Pei ◽  
Joann W. Ng ◽  
...  
Keyword(s):  
Cell Death ◽  
Muscle Tissue ◽  
Pressure Ulcer ◽  
Molecular Mechanisms ◽  
Caspase 3 ◽  
Tissue Injury ◽  
Immunocytochemical Staining ◽  
Sprague Dawley ◽  
Deep Tissue ◽  
Deep Tissue Injury

Pressure ulcer is a complex and significant health problem. Although the factors including pressure, shear, and ischemia have been identified in the etiology of pressure ulcer, the cellular and molecular mechanisms that contribute to the development of pressure ulcer are unclear. This study tested the hypothesis that the early-onset molecular regulation of pressure ulcer involves apoptosis in muscle tissue. Adult Sprague-Dawley rats were subjected to an in vivo protocol to mimic pressure-induced deep tissue injury. Static pressure was applied to the tibialis region of the right limb of the rats for 6 h each day on two consecutive days. The compression force was continuously monitored by a three-axial force transducer equipped in the compression indentor. The contralateral uncompressed limb served as intra-animal control. Tissues underneath the compressed region were collected for histological analysis, terminal dUTP nick-end labeling (TUNEL), cell death ELISA, immunocytochemical staining, and real-time RT-PCR gene expression analysis. The compressed muscle tissue generally demonstrated degenerative characteristics. TUNEL/dystrophin labeling showed a significant increase in the apoptotic muscle-related nuclei, and cell death ELISA demonstrated a threefold elevation of apoptotic DNA fragmentation in the compressed muscle tissue relative to control. Positive immunoreactivities of cleaved caspase-3, Bax, and Bcl-2 were evident in compressed muscle. The mRNA contents of Bax, caspase-3, caspase-8, and caspase-9 were found to be higher in the compressed muscle tissue than control. These results demonstrated that apoptosis is activated in muscle tissue following prolonged moderate compression. The data are consistent with the hypothesis that muscle apoptosis is involved in the underlying mechanism of pressure-induced deep tissue injury.

scholarly journals Hydrogel plus growth factors treatment after 2940nm erbium:YAG lattice laser improves periorbital wrinkles and wound healing: a case report

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110425
Author(s):  
Jiaqi Zeng ◽  
Zhen Li ◽  
Feiyan Lin ◽  
Shaohong Fu ◽  
Jingyi Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Case Report ◽  
Laser Therapy ◽  
Wound Care ◽  
Healing Process ◽  
Alternative Therapy ◽  
Skin Aging ◽  
Wound Healing Process ◽  
Gel Treatment ◽  
The Right

Skin aging is an inevitable physiological process and periorbital wrinkling is an active sign of the process. Laser therapy is an effective method for improving periorbital wrinkles and wound care after laser therapy can accelerate the wound healing process. This case report describes a typical case of a 47-year-old male that presented with a 10-year history of gradually-worsening bilateral periorbital wrinkles. These were treated using a 2940 nm erbium (Er):YAG lattice laser combined with recombinant bovine basic fibroblast growth factor (bFGF) gel and hydrogel (HG) treatment on the left side of his face compared with laser therapy and bFGF gel on the right side of his face. HG combined with bFGF gel treatment after 2940 nm Er:YAG lattice laser therapy improved postoperative swelling and pigmentation compared with bFGF gel alone; and it promoted periorbital wrinkle improvement and wound healing. In conclusion, HG combined with GFs after laser therapy could be an alternative therapy for periorbital wrinkles.

scholarly journals Deep tissue injury rat model for pressure ulcer research on spinal cord injury

2010 ◽  
Vol 19 (2) ◽  
pp. 67-76 ◽  
Author(s):  
Fang Lin ◽  
Atek Pandya ◽  
Andrew Cichowski ◽  
Mauli Modi ◽  
Briana Reprogle ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pressure Ulcer ◽  
Rat Model ◽  
Tissue Injury ◽  
Deep Tissue ◽  
Deep Tissue Injury ◽  
Cord Injury

scholarly journals Osteosarcoma of III metacarpal bone in a 13-year-old girl (case report)

2020 ◽  
Vol 10 (4) ◽  
pp. 445-451
Author(s):  
Kazbek F. Savlaev ◽  
Anna V. Petrichenko ◽  
Dilmurod K. Nishonov ◽  
Nadejda M. Ivanova ◽  
Timur A. Sharoev
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Malignant Neoplasm ◽  
Metacarpal Bone ◽  
Rare Tumor ◽  
Telangiectatic Osteosarcoma ◽  
The Third ◽  
Artificial Grafts ◽  
Metacarpal Bones ◽  
The Right

Osteosarcoma is the most common primary malignant neoplasm of bones in children; this tumor accounts for 50 to 80% of all skeletal sarcomas. Less often, osteosarcoma affects flat bones (scapula, ribs, bones of the skull and pelvis), bones of the foot, hand and spine. Description of the observation. A 13-year-old girl, 8 months before admission to the clinic, began to complain of pain in her right hand, six months later, a swelling appeared in this area. After radiography, which revealed a bone tumor of the III metacarpal bone, a trepanobiopsy with histological examination was performed. Conclusion: subperiosteal telangiectatic osteosarcoma G II. The child was admitted to the oncology department in November 2018. Before the operation, the girl underwent 4 courses of chemotherapy, as a result of which the tumor reduced in size, which made it possible to perform organ-preserving surgical treatment extirpation of the third metacarpal bone affected by the tumor, followed by autoplasty from the wing of the right iliac bone with fixation of the graft Kirschner needles. The postoperative period passed without complications. As a result of the operation, it was not only possible to radically remove the tumor, but also to preserve 3 fingers of the right (working) hand with good functionality. After surgery, the child received 5 courses of polychemotherapy and is currently in remission. Conclusion. The above observation demonstrates the possibility of performing organ-preserving surgeries using bone autoplasty for rare tumor lesions of the metacarpal bones. This method is more physiological in comparison with the use of allo- or artificial grafts.

Pressure-Related Deep Tissue Injury under Intact Skin and the Current Pressure Ulcer Staging Systems

2005 ◽  
Vol 18 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Michael A. Ankrom ◽  
Richard G. Bennett ◽  
Stephen Sprigle ◽  
Diane Langemo ◽  
Joyce M. Black ◽  
...  
Keyword(s):  
Pressure Ulcer ◽  
Tissue Injury ◽  
Intact Skin ◽  
Deep Tissue ◽  
Deep Tissue Injury ◽  
Staging Systems
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