scholarly journals Detection of illegally added drugs in dietary supplements by near-infrared spectral imaging

2014 ◽  
Vol 07 (06) ◽  
pp. 1450032 ◽  
Author(s):  
Rui Zhang ◽  
Lihui Yin ◽  
Shaohong Jin
Keyword(s):  
Dietary Supplements ◽  
Correlation Coefficient ◽  
False Positive ◽  
Near Infrared ◽  
Spectral Imaging ◽  
Test Results ◽  
Infrared Spectral ◽  
Positive Results

The application to detect illegally added drugs in dietary supplements by near-infrared spectral imaging was studied with the focus on nifedipine, diclofenac and metformin. The method is based on near-infrared spectral images correlation coefficient to detect illegally added drugs. The results comply 100% with HPLC methods test results with no false positive results.

Three Years of Experience With Random Urinary Homovanillic and Vanillylmandelic Acid Levels in the Diagnosis of Neuroblastoma

PEDIATRICS ◽  
1987 ◽  
Vol 79 (2) ◽  
pp. 203-205
Author(s):  
Mendel Tuchman ◽  
Margaret L. R. Ramnaraine ◽  
William G. Woods ◽  
William Krivit
Keyword(s):  
False Positive ◽  
Homovanillic Acid ◽  
False Negative ◽  
False Negative Rate ◽  
Urine Samples ◽  
Vanillylmandelic Acid ◽  
Test Results ◽  
Upper Limit ◽  
Positive Results ◽  
Rule Out

During the last 3 years, random urine samples from 408 patients were tested for elevated homovanillic acid (HVA) and vanillylmandelic acid (VMA) levels to rule out the diagnosis of neuroblastoma. Thirty-seven of these patients had elevated HVA and/or VMA levels, and neuroblastoma was subsequently diagnosed. In three additional patients with negative test results (normal HVA and VMA levels), tumors were subsequently diagnosed (false-negative rate of 7.5%). Ten percent of the patients with neuroblastoma had normal HVA and 27.5% had normal VMA levels at the time of diagnosis. Only one patient (2.5%) with neuroblastoma had elevated VMA levels in the presence of normal HVA levels. More than 60% of the patients with neuroblastoma had urinary HVA and/or VMA levels higher than twice the upper limit of normal. No false-positive results were encountered. Age and stage distributions of the patients are shown, and the significance of the results is discussed.

scholarly journals Psychological Impact of NBS for CF

2020 ◽  
Vol 6 (2) ◽  
pp. 27 ◽  
Author(s):  
Jane Chudleigh ◽  
Holly Chinnery
Keyword(s):  
Cystic Fibrosis ◽  
Newborn Screening ◽  
Health Professionals ◽  
False Positive ◽  
Psychological Impact ◽  
Confirmatory Test ◽  
Test Results ◽  
Burden Of Care ◽  
Positive Results ◽  
Screening Result

Newborn screening for cystic fibrosis has resulted in diagnosis often before symptoms are recognised, leading to benefits including reduced disease severity, decreased burden of care, and lower costs. The psychological impact of this often unsought diagnosis on the parents of seemingly well children is less well understood. The time during which the screening result is communicated to families but before the confirmatory test results are available is recognised as a period of uncertainty and it is this uncertainty that can impact most on parents. Evidence suggests this may be mitigated against by ensuring the time between communication and confirmatory testing is minimized and health professionals involved in communicating positive newborn screening results and diagnostic results for cystic fibrosis to families are knowledgeable and able to provide appropriate reassurance. This is particularly important in the case of false positive results or when the child is given a Cystic Fibrosis Screen Positive, Inconclusive Diagnosis designation. However, to date, there are no formal mechanisms in place to support health professionals undertaking this challenging role, which would enable them to meet the expectations set out in specific guidance.

scholarly journals Near-infrared spectral imaging for quality assurance of pharmaceutical products: Analysis of tablets to assess powder blend homogeneity

2002 ◽  
Vol 3 (3) ◽  
pp. 1-15 ◽  
Author(s):  
Robbe C. Lyon ◽  
David S. Lester ◽  
E. Neil Lewis ◽  
Eunah Lee ◽  
Lawrence X. Yu ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Near Infrared ◽  
Spectral Imaging ◽  
Pharmaceutical Products ◽  
Powder Blend ◽  
Products Analysis ◽  
Infrared Spectral

The Effect of Anesthesia Type During Delivery on Neonatal Otoacoustic Emission Hearing Test Results: A Tertiary Center Experience

2020 ◽  
Author(s):  
Betül Yakıştıran ◽  
Mehmet Karslı ◽  
Emre Canpolat ◽  
Yüksel Oğuz ◽  
Orhan Altınboğa ◽  
...  
Keyword(s):  
General Anesthesia ◽  
Spinal Anesthesia ◽  
False Positive ◽  
Otoacoustic Emission ◽  
Test Results ◽  
General Anesthesia Group ◽  
Anesthesia Group ◽  
Hearing Test ◽  
Spinal Anesthesia Group ◽  
Positive Results

Abstract Background Hearing is essential for the healthy development of an infant as language is one of the main stimulants of intellectual capacity. We investigate the effect of anesthesia type during delivery on neonatal otoacoustic emission (OAE) hearing test results. Methods This retrospective cross-sectional study includes 1,493 healthy, full-term (39/0–40/6 gestational weeks) newborns of healthy women and who were delivered by cesarean section. Newborns were divided into 2 groups based on their anesthesia type during delivery: 1) general anesthesia group (n=160), and 2) spinal anesthesia group (n=1333). Maternal age, anesthesia type, birth weight, gestational age at birth, neonatal gender, 1st–5th minute APGAR scores, and OAE results were compared between the groups. Results 1287 (86.2%) newborns were reported to have passed the first step of OAE; 206 (13.8%) newborns were reported to have failed the first step and passed the second test. In the general anesthesia group, 133 (83.1%) of the newborns passed the first OAE test and 27 (16.9%) newborns had false-positive results. In the spinal anesthesia group, 1,154 (86.6%) of the newborns passed the first OAE test and 179 (13.4%) newborns had false-positive results. The difference between the 2 groups by false-positive values was found to be statistically significant (p<0.001). Conclusions Type of delivery anesthesia may have an effect on the false-positive rates of OAE test results.

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